Influenza virus subpopulations: exchange of lethal H5N1 virus NS for H1N1 virus NS triggers de novo generation of defective-interfering particles and enhances interferon-inducing particle efficiency

Reassortment of influenza A viruses is known to affect viability, replication efficiency, antigenicity, host range, and virulence, and can generate pandemic strains. In this study, we demonstrated that the specific exchange of the NS gene segment from highly pathogenic A/HK/156/97 (H5N1) [E92 or E92...

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Veröffentlicht in:	Journal of interferon & cytokine research 2013-03, Vol.33 (3), p.99-107
Hauptverfasser:	Ngunjiri, John M, Buchek, Gregory M, Mohni, Kareem N, Sekellick, Margaret J, Marcus, Philip I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cells, Cultured Chick Embryo Humans Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - genetics Influenza Vaccines - immunology Interferons - immunology Sequence Deletion Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology
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