Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?
The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting. Sentinel and echelon lymph nodes were identified by means of a combination...
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| Veröffentlicht in: | South African journal of surgery 2013-02, Vol.51 (1), p.22-25 |
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| container_title | South African journal of surgery |
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| creator | Edkins, O Hofmeyr, C Fagan, J J |
| description | The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting.
Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye identification. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection.
Thirty-three patients were included in the study, 13 in the node-negative (N0) and 20 in the node-positive (N+) group. In the clinically N0 group the sensitivity of SLNB was 100% and the negative predictive value (NPV) 100%. In the clinically N+ group the sensitivity was 71% and the NPV 60% for staging the nodal status of the neck. CONCLUSIONS; The accuracy of SLNB in the clinically N+ neck is too low for SLNB to be a means of avoiding comprehensive neck dissection.
2B. |
| doi_str_mv | 10.7196/sajs.1357 |
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Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye identification. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection.
Thirty-three patients were included in the study, 13 in the node-negative (N0) and 20 in the node-positive (N+) group. In the clinically N0 group the sensitivity of SLNB was 100% and the negative predictive value (NPV) 100%. In the clinically N+ group the sensitivity was 71% and the NPV 60% for staging the nodal status of the neck. CONCLUSIONS; The accuracy of SLNB in the clinically N+ neck is too low for SLNB to be a means of avoiding comprehensive neck dissection.
2B.</description><identifier>ISSN: 0038-2361</identifier><identifier>EISSN: 2078-5151</identifier><identifier>DOI: 10.7196/sajs.1357</identifier><identifier>PMID: 23472648</identifier><language>eng</language><publisher>South Africa: Medpharm Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Care and treatment ; Diagnosis ; Dissection ; Female ; Head & neck cancer ; Head and neck cancer ; Health aspects ; Humans ; Lymph Nodes - pathology ; Lymphatic system ; Male ; Middle Aged ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neck ; Neoplasm Staging ; Oropharyngeal Neoplasms - pathology ; Oropharyngeal Neoplasms - surgery ; Predictive Value of Tests ; Sentinel Lymph Node Biopsy ; Squamous cell carcinoma</subject><ispartof>South African journal of surgery, 2013-02, Vol.51 (1), p.22-25</ispartof><rights>COPYRIGHT 2013 Medpharm Publications</rights><rights>2013. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23472648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edkins, O</creatorcontrib><creatorcontrib>Hofmeyr, C</creatorcontrib><creatorcontrib>Fagan, J J</creatorcontrib><title>Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?</title><title>South African journal of surgery</title><addtitle>S Afr J Surg</addtitle><description>The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting.
Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye identification. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection.
Thirty-three patients were included in the study, 13 in the node-negative (N0) and 20 in the node-positive (N+) group. In the clinically N0 group the sensitivity of SLNB was 100% and the negative predictive value (NPV) 100%. In the clinically N+ group the sensitivity was 71% and the NPV 60% for staging the nodal status of the neck. CONCLUSIONS; The accuracy of SLNB in the clinically N+ neck is too low for SLNB to be a means of avoiding comprehensive neck dissection.
2B.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Dissection</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neck</subject><subject>Neoplasm Staging</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Squamous cell carcinoma</subject><issn>0038-2361</issn><issn>2078-5151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkV9r1UAQxRex2Nvqg19AFgTxJdfdnf2TPEmpVgsFX_TVMNlMevea7KbZpHC_faNWtFLmYWDmdw6HGcZeSrF1srLvMu7zVoJxT9hGCVcWRhr5lG2EgLJQYOUxO8l5L4QGZ-wzdqxAO2V1uWHfPyTKPFOcQ6Se94dh3PGYWuJNSGM-8B3eEkc-pZ54iL9WxZhymMM63xG2HGPLI_kfPN8sOKQlc4-TDzEN-P45O-qwz_Tivp-ybxcfv55_Lq6-fLo8P7sqrsHZuYAWnfNdIx2psoPKVyTAlYCNsSWSdVUD3moNsoRSaDLek1MaG6eN6DTCKXv723ec0s1Cea6HkD31PUZaE9USpBVGy0qt6Ov_0H1aprimq5UVWkhttPhLXWNPdYhdmif0P03rM1AAutJKr9T2EWqtlobgU6QurPMHgjf_CNbz9fMup36ZQ4r5IfjqPuXSDNTW4xQGnA71n8_BHeETllI</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Edkins, O</creator><creator>Hofmeyr, C</creator><creator>Fagan, J J</creator><general>Medpharm Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?</title><author>Edkins, O ; Hofmeyr, C ; Fagan, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g376t-3da77cfb17e28f39c9e03783ab568ae679b3c6443183804e5cce724ab7450f4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Dissection</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neck</topic><topic>Neoplasm Staging</topic><topic>Oropharyngeal Neoplasms - pathology</topic><topic>Oropharyngeal Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edkins, O</creatorcontrib><creatorcontrib>Hofmeyr, C</creatorcontrib><creatorcontrib>Fagan, J J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>South African journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edkins, O</au><au>Hofmeyr, C</au><au>Fagan, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?</atitle><jtitle>South African journal of surgery</jtitle><addtitle>S Afr J Surg</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>51</volume><issue>1</issue><spage>22</spage><epage>25</epage><pages>22-25</pages><issn>0038-2361</issn><eissn>2078-5151</eissn><abstract>The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting.
Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye identification. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection.
Thirty-three patients were included in the study, 13 in the node-negative (N0) and 20 in the node-positive (N+) group. In the clinically N0 group the sensitivity of SLNB was 100% and the negative predictive value (NPV) 100%. In the clinically N+ group the sensitivity was 71% and the NPV 60% for staging the nodal status of the neck. CONCLUSIONS; The accuracy of SLNB in the clinically N+ neck is too low for SLNB to be a means of avoiding comprehensive neck dissection.
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; African Journals Online (Open Access) |
| subjects | Adult Aged Aged, 80 and over Biopsy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Care and treatment Diagnosis Dissection Female Head & neck cancer Head and neck cancer Health aspects Humans Lymph Nodes - pathology Lymphatic system Male Middle Aged Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neck Neoplasm Staging Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - surgery Predictive Value of Tests Sentinel Lymph Node Biopsy Squamous cell carcinoma |
| title | Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma? |
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