Tuning drug release from smart microgelahydrogel composites via cross-linking
Soft nanocomposite hydrogels consisting of thermoresponsive microgels physically entrapped or covalently cross-linked to a non-thermoresponsive hydrogel are synthesized and tested for their capacity to facilitate long-term drug release of a small molecule drug. Copolymer microgels based on N-isoprop...
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Veröffentlicht in: | Journal of colloid and interface science 2013-02, Vol.392, p.422-430 |
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creator | Sivakumaran, Daryl Maitland, Danielle Oszustowicz, Thomas Hoare, Todd |
description | Soft nanocomposite hydrogels consisting of thermoresponsive microgels physically entrapped or covalently cross-linked to a non-thermoresponsive hydrogel are synthesized and tested for their capacity to facilitate long-term drug release of a small molecule drug. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited ionic affinity for binding to bupivacaine, a cationic local anesthetic. These microgels were subsequently physically entrapped within an in situ-gelling carbohydrate-based hydrogel network cross-linked via hydrazideaaldehyde chemistry; alternately, hydrazide-functionalized microgels were prepared that covalently cross-linked to the bulk hydrogel phase. Both the overall rate of drug release and the magnitude of the burst release were significantly decreased when microgels were restricted from undergoing a phase transition between the preparation temperature of the nanocomposite (25 degree C) and the test temperature (37 degree C), whether deswelling was inhibited by increasing the cross-link density within the microgel itself or by cross-linking the microgel to the bulk hydrogel network. This result facilitates facile tuning of soft nanocomposite drug delivery systems to achieve targeted drug release kinetics. |
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Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited ionic affinity for binding to bupivacaine, a cationic local anesthetic. These microgels were subsequently physically entrapped within an in situ-gelling carbohydrate-based hydrogel network cross-linked via hydrazideaaldehyde chemistry; alternately, hydrazide-functionalized microgels were prepared that covalently cross-linked to the bulk hydrogel phase. Both the overall rate of drug release and the magnitude of the burst release were significantly decreased when microgels were restricted from undergoing a phase transition between the preparation temperature of the nanocomposite (25 degree C) and the test temperature (37 degree C), whether deswelling was inhibited by increasing the cross-link density within the microgel itself or by cross-linking the microgel to the bulk hydrogel network. 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Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited ionic affinity for binding to bupivacaine, a cationic local anesthetic. These microgels were subsequently physically entrapped within an in situ-gelling carbohydrate-based hydrogel network cross-linked via hydrazideaaldehyde chemistry; alternately, hydrazide-functionalized microgels were prepared that covalently cross-linked to the bulk hydrogel phase. Both the overall rate of drug release and the magnitude of the burst release were significantly decreased when microgels were restricted from undergoing a phase transition between the preparation temperature of the nanocomposite (25 degree C) and the test temperature (37 degree C), whether deswelling was inhibited by increasing the cross-link density within the microgel itself or by cross-linking the microgel to the bulk hydrogel network. This result facilitates facile tuning of soft nanocomposite drug delivery systems to achieve targeted drug release kinetics.</description><subject>Crosslinking</subject><subject>Drugs</subject><subject>Hydrogels</subject><subject>Microgels</subject><subject>Nanocomposites</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Tuning</subject><issn>0021-9797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVjL0OgjAURjtoIv68wx1dSFoRobPRuLixkwYuWO0P9lIT315ifAGn7yTn5JuxhPOdSGUhiwVbEt05FyLPZcKuVXTa9dCG2ENAg4oQuuAtkFVhBKub4Hs06vZuvwCNt4MnPSLBSyuYNFFqtHtMN2s275Qh3Px2xbbnU3W8pEPwz4g01lZTg8Yohz5SLTKRH0pe7nn2R_oBUJ1CXQ</recordid><startdate>20130215</startdate><enddate>20130215</enddate><creator>Sivakumaran, Daryl</creator><creator>Maitland, Danielle</creator><creator>Oszustowicz, Thomas</creator><creator>Hoare, Todd</creator><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20130215</creationdate><title>Tuning drug release from smart microgelahydrogel composites via cross-linking</title><author>Sivakumaran, Daryl ; Maitland, Danielle ; Oszustowicz, Thomas ; Hoare, Todd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_13156808403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Crosslinking</topic><topic>Drugs</topic><topic>Hydrogels</topic><topic>Microgels</topic><topic>Nanocomposites</topic><topic>Nanomaterials</topic><topic>Nanostructure</topic><topic>Tuning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sivakumaran, Daryl</creatorcontrib><creatorcontrib>Maitland, Danielle</creatorcontrib><creatorcontrib>Oszustowicz, Thomas</creatorcontrib><creatorcontrib>Hoare, Todd</creatorcontrib><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of colloid and interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sivakumaran, Daryl</au><au>Maitland, Danielle</au><au>Oszustowicz, Thomas</au><au>Hoare, Todd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuning drug release from smart microgelahydrogel composites via cross-linking</atitle><jtitle>Journal of colloid and interface science</jtitle><date>2013-02-15</date><risdate>2013</risdate><volume>392</volume><spage>422</spage><epage>430</epage><pages>422-430</pages><issn>0021-9797</issn><abstract>Soft nanocomposite hydrogels consisting of thermoresponsive microgels physically entrapped or covalently cross-linked to a non-thermoresponsive hydrogel are synthesized and tested for their capacity to facilitate long-term drug release of a small molecule drug. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited ionic affinity for binding to bupivacaine, a cationic local anesthetic. These microgels were subsequently physically entrapped within an in situ-gelling carbohydrate-based hydrogel network cross-linked via hydrazideaaldehyde chemistry; alternately, hydrazide-functionalized microgels were prepared that covalently cross-linked to the bulk hydrogel phase. Both the overall rate of drug release and the magnitude of the burst release were significantly decreased when microgels were restricted from undergoing a phase transition between the preparation temperature of the nanocomposite (25 degree C) and the test temperature (37 degree C), whether deswelling was inhibited by increasing the cross-link density within the microgel itself or by cross-linking the microgel to the bulk hydrogel network. This result facilitates facile tuning of soft nanocomposite drug delivery systems to achieve targeted drug release kinetics.</abstract></addata></record> |
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subjects | Crosslinking Drugs Hydrogels Microgels Nanocomposites Nanomaterials Nanostructure Tuning |
title | Tuning drug release from smart microgelahydrogel composites via cross-linking |
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