A coupled cantilever-microelectrode biosensor for enhanced pathogen detection
A pathogen detection platform that integrates electrokinetically accelerated sampling with electromechanical signal transduction is presented. Detection of pathogens without the need for cultivation is achieved by employing a prototype device that combines microelectrodes embedded directly onto the...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2013-01, Vol.176, p.248-252 |
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| container_title | Sensors and actuators. B, Chemical |
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| creator | Tomkins, Matthew R. Chow, Jacky Lai, Yongjun Docoslis, Aristides |
| description | A pathogen detection platform that integrates electrokinetically accelerated sampling with electromechanical signal transduction is presented. Detection of pathogens without the need for cultivation is achieved by employing a prototype device that combines microelectrodes embedded directly onto the surface of a cantilever beam. Escherichia coli bacteria captured on the surface of the cantilever with the aid of AC electrokinetic effects (dielectrophoresis) within 30min of sampling time were found to cause substantial resonant frequency shifts compared to unassisted capture. The effect of the cantilever's resonant mode was also examined in order to identify conditions that can improve detection sensitivity. |
| doi_str_mv | 10.1016/j.snb.2012.09.020 |
| format | Article |
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B, Chemical</title><description>A pathogen detection platform that integrates electrokinetically accelerated sampling with electromechanical signal transduction is presented. Detection of pathogens without the need for cultivation is achieved by employing a prototype device that combines microelectrodes embedded directly onto the surface of a cantilever beam. Escherichia coli bacteria captured on the surface of the cantilever with the aid of AC electrokinetic effects (dielectrophoresis) within 30min of sampling time were found to cause substantial resonant frequency shifts compared to unassisted capture. The effect of the cantilever's resonant mode was also examined in order to identify conditions that can improve detection sensitivity.</description><subject>AC electrokinetics</subject><subject>Bacteria</subject><subject>Biosensor</subject><subject>biosensors</subject><subject>Cantilever</subject><subject>Dielectrophoresis</subject><subject>Escherichia coli</subject><subject>microbial detection</subject><subject>pathogens</subject><subject>signal transduction</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAURS0EEqXwA5jIyJLw7DiOI6aq4ksqYoDOVuo8t67SONhpJf49jsLM8PSWc690DyG3FDIKVDzss9BtMgaUZVBlwOCMzKgs8zSHsjwnM6hYkXKA4pJchbAHAJ4LmJH3RaLdsW-xSXTdDbbFE_r0YLV32KIevGsw2VgXsAvOJyYedru60zHQ18PObbFLGhwial13TS5M3Qa8-ftzsn5--lq-pquPl7flYpXqvOBD2khR8rJsuBFcGAFUsooZwaRhICtqsMxLTblAyaUBkEwK2HBWcEYbI4oqn5P7qbf37vuIYVAHGzS2bd2hOwZFc1oIDjKnEaUTGheF4NGo3ttD7X8UBTWqU3sV1alRnYJKRXUxczdlTO1UvfU2qPVnBAoASgWrRuJxIjCuPFn0KmiLoxXrowrVOPtP_y9udn6_</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Tomkins, Matthew R.</creator><creator>Chow, Jacky</creator><creator>Lai, Yongjun</creator><creator>Docoslis, Aristides</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201301</creationdate><title>A coupled cantilever-microelectrode biosensor for enhanced pathogen detection</title><author>Tomkins, Matthew R. ; Chow, Jacky ; Lai, Yongjun ; Docoslis, Aristides</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-d867477d4f646f6018292f628f20891fe737c146e848f0082860b425421df6593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>AC electrokinetics</topic><topic>Bacteria</topic><topic>Biosensor</topic><topic>biosensors</topic><topic>Cantilever</topic><topic>Dielectrophoresis</topic><topic>Escherichia coli</topic><topic>microbial detection</topic><topic>pathogens</topic><topic>signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomkins, Matthew R.</creatorcontrib><creatorcontrib>Chow, Jacky</creatorcontrib><creatorcontrib>Lai, Yongjun</creatorcontrib><creatorcontrib>Docoslis, Aristides</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Sensors and actuators. 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Escherichia coli bacteria captured on the surface of the cantilever with the aid of AC electrokinetic effects (dielectrophoresis) within 30min of sampling time were found to cause substantial resonant frequency shifts compared to unassisted capture. The effect of the cantilever's resonant mode was also examined in order to identify conditions that can improve detection sensitivity.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2012.09.020</doi><tpages>5</tpages></addata></record> |
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| ispartof | Sensors and actuators. B, Chemical, 2013-01, Vol.176, p.248-252 |
| issn | 0925-4005 1873-3077 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | AC electrokinetics Bacteria Biosensor biosensors Cantilever Dielectrophoresis Escherichia coli microbial detection pathogens signal transduction |
| title | A coupled cantilever-microelectrode biosensor for enhanced pathogen detection |
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