Oxidation of Adenosine and Inosine: The Chemistry of 8‑Oxo-7,8-dihydropurines, Purine Iminoquinones, and Purine Quinones as Observed by Ultrafast Spectroscopy

Oxidative damage to purine nucleic acid bases proceeds through quinoidal intermediates derived from their corresponding 8-oxo-7,8-dihydropurine bases. Oxidation studies of 8-oxo-7,8-dihyroadenosine and 8-oxo-7,8-dihydroinosine indicate that these quinoidal species can produce stable cross-links with...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-03, Vol.135 (9), p.3423-3438
Hauptverfasser:	Nilov, Denis I, Komarov, Dmitry Y, Panov, Maxim S, Karabaeva, Kanykey E, Mereshchenko, Andrey S, Tarnovsky, Alexander N, Wilson, R. Marshall
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemistry Inosine - chemistry Molecular Structure Oxidation-Reduction Purines - chemistry Quinones - chemistry Spectrum Analysis
Online-Zugang:	Volltext
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