Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis
Abstract The relationship of neurocognitive course with clinical and functional outcomes in psychosis is not well known, especially in the long term. The aim of the study was to examine the clinical and neuropsychological course of first-episode psychosis patients at 5-year follow-up and analyze the...
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| Veröffentlicht in: | Psychiatry research 2013-03, Vol.206 (1), p.8-16 |
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| creator | González-Ortega, Itxaso de los Mozos, Vanesa Echeburúa, Enrique Mezo, Maria Besga, Ariadna Ruiz de Azúa, Sonia González-Pinto, Asunción Gutierrez, Miguel Zorrilla, Iñaki González-Pinto, Ana |
| description | Abstract The relationship of neurocognitive course with clinical and functional outcomes in psychosis is not well known, especially in the long term. The aim of the study was to examine the clinical and neuropsychological course of first-episode psychosis patients at 5-year follow-up and analyze the relationship of cognitive performance with clinical and functional outcome. The 5-year follow-up was conducted with 26 first-episode psychosis patients. Psychotic symptoms were measured by the Positive and Negative Syndrome Scale, manic and depressive symptoms by the Young Mania Rating Scale and Hamilton Depression Rating Scale respectively, and psychosocial functioning by the Functioning Assessment Short Test. The cognitive domains were assessed by the Wechsler Adult Intelligence Scale, the Wisconsin Card Sorting Test, the Trail Making Test, the Verbal Fluency Test, the Stroop Colour–Word Test and the Wechsler Memory Scale. Patients showed symptomatic improvement in the follow-up except in negative psychotic symptoms. There was also improvement in most cognitive domains except in working memory and processing speed in the follow-up. Working memory impairment was associated to negative psychotic symptoms and poor functional outcomes. Negative symptoms mediated the relationship between working memory and outcome. Therefore, negative symptoms should be a primary target of treatment to improve functional outcomes. |
| doi_str_mv | 10.1016/j.psychres.2012.08.025 |
| format | Article |
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The aim of the study was to examine the clinical and neuropsychological course of first-episode psychosis patients at 5-year follow-up and analyze the relationship of cognitive performance with clinical and functional outcome. The 5-year follow-up was conducted with 26 first-episode psychosis patients. Psychotic symptoms were measured by the Positive and Negative Syndrome Scale, manic and depressive symptoms by the Young Mania Rating Scale and Hamilton Depression Rating Scale respectively, and psychosocial functioning by the Functioning Assessment Short Test. The cognitive domains were assessed by the Wechsler Adult Intelligence Scale, the Wisconsin Card Sorting Test, the Trail Making Test, the Verbal Fluency Test, the Stroop Colour–Word Test and the Wechsler Memory Scale. Patients showed symptomatic improvement in the follow-up except in negative psychotic symptoms. There was also improvement in most cognitive domains except in working memory and processing speed in the follow-up. Working memory impairment was associated to negative psychotic symptoms and poor functional outcomes. Negative symptoms mediated the relationship between working memory and outcome. Therefore, negative symptoms should be a primary target of treatment to improve functional outcomes.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2012.08.025</identifier><identifier>PMID: 22985548</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Attention - physiology ; Biological and medical sciences ; Cognition ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Executive Function - physiology ; Female ; First episode psychosis ; Follow-up ; Functional outcome ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Memory Disorders - diagnosis ; Memory Disorders - etiology ; Memory, Short-Term - physiology ; Negative symptoms ; Neuropsychological Tests ; Other psychotic disorders ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - complications ; Psychotic Disorders - diagnosis ; Psychotic Disorders - psychology ; Severity of Illness Index ; Verbal Learning - physiology ; Working memory ; Young Adult</subject><ispartof>Psychiatry research, 2013-03, Vol.206 (1), p.8-16</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-66da040d2ac936f2c0965eac1534e80286c67f97faa4e75ea3d451133109ca643</citedby><cites>FETCH-LOGICAL-c519t-66da040d2ac936f2c0965eac1534e80286c67f97faa4e75ea3d451133109ca643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016517811200457X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27165775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22985548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Ortega, Itxaso</creatorcontrib><creatorcontrib>de los Mozos, Vanesa</creatorcontrib><creatorcontrib>Echeburúa, Enrique</creatorcontrib><creatorcontrib>Mezo, Maria</creatorcontrib><creatorcontrib>Besga, Ariadna</creatorcontrib><creatorcontrib>Ruiz de Azúa, Sonia</creatorcontrib><creatorcontrib>González-Pinto, Asunción</creatorcontrib><creatorcontrib>Gutierrez, Miguel</creatorcontrib><creatorcontrib>Zorrilla, Iñaki</creatorcontrib><creatorcontrib>González-Pinto, Ana</creatorcontrib><title>Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract The relationship of neurocognitive course with clinical and functional outcomes in psychosis is not well known, especially in the long term. The aim of the study was to examine the clinical and neuropsychological course of first-episode psychosis patients at 5-year follow-up and analyze the relationship of cognitive performance with clinical and functional outcome. The 5-year follow-up was conducted with 26 first-episode psychosis patients. Psychotic symptoms were measured by the Positive and Negative Syndrome Scale, manic and depressive symptoms by the Young Mania Rating Scale and Hamilton Depression Rating Scale respectively, and psychosocial functioning by the Functioning Assessment Short Test. The cognitive domains were assessed by the Wechsler Adult Intelligence Scale, the Wisconsin Card Sorting Test, the Trail Making Test, the Verbal Fluency Test, the Stroop Colour–Word Test and the Wechsler Memory Scale. Patients showed symptomatic improvement in the follow-up except in negative psychotic symptoms. There was also improvement in most cognitive domains except in working memory and processing speed in the follow-up. Working memory impairment was associated to negative psychotic symptoms and poor functional outcomes. Negative symptoms mediated the relationship between working memory and outcome. Therefore, negative symptoms should be a primary target of treatment to improve functional outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Attention - physiology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>First episode psychosis</subject><subject>Follow-up</subject><subject>Functional outcome</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - etiology</subject><subject>Memory, Short-Term - physiology</subject><subject>Negative symptoms</subject><subject>Neuropsychological Tests</subject><subject>Other psychotic disorders</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - psychology</subject><subject>Severity of Illness Index</subject><subject>Verbal Learning - physiology</subject><subject>Working memory</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAQgC0EokvhL1S-IHFJ8CO2kwsCVeUhVeIACG6WcSbF28QOnqRS_j1edgsSF04--JvXN0PIBWc1Z1y_3Nczbv5HBqwF46Jmbc2EekB2vDWiMlzIh2RXQFVx0_Iz8gRxzxgTvOsekzMhulappt2R_mvKtyHe0AmmlDfqkDo6Z-iDX1KmaaARbtwS7oDiNs1LmgoQezqs0S8hRTfStC4-TUBDpEPIuFCYA6Ye6O8OEwZ8Sh4NbkR4dnrPyZe3V58v31fXH999uHxzXXnFu6XSunesYb1wvpN6EJ51WoHzXMkGWiZa7bUZOjM414ApP7JvFOdSctZ5pxt5Tl4c8845_VwBFzsF9DCOLkJa0XLJlZaNUm1B9RH1OSFmGOycw-TyZjmzB8N2b-8N24Nhy1pbDJfAi1ON9fsE_Z-we6UFeH4CHHo3DtlFH_AvZ8pSjDkken3koBi5C5At-gDRF_UZ_GL7FP7fy6t_UvgxxFCq3sIGuE9rLgsqc1ssMfbT4R4O58AFY40y3-Qvk7yzfA</recordid><startdate>20130330</startdate><enddate>20130330</enddate><creator>González-Ortega, Itxaso</creator><creator>de los Mozos, Vanesa</creator><creator>Echeburúa, Enrique</creator><creator>Mezo, Maria</creator><creator>Besga, Ariadna</creator><creator>Ruiz de Azúa, Sonia</creator><creator>González-Pinto, Asunción</creator><creator>Gutierrez, Miguel</creator><creator>Zorrilla, Iñaki</creator><creator>González-Pinto, Ana</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130330</creationdate><title>Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis</title><author>González-Ortega, Itxaso ; de los Mozos, Vanesa ; Echeburúa, Enrique ; Mezo, Maria ; Besga, Ariadna ; Ruiz de Azúa, Sonia ; González-Pinto, Asunción ; Gutierrez, Miguel ; Zorrilla, Iñaki ; González-Pinto, Ana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-66da040d2ac936f2c0965eac1534e80286c67f97faa4e75ea3d451133109ca643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Attention - physiology</topic><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>First episode psychosis</topic><topic>Follow-up</topic><topic>Functional outcome</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - etiology</topic><topic>Memory, Short-Term - physiology</topic><topic>Negative symptoms</topic><topic>Neuropsychological Tests</topic><topic>Other psychotic disorders</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - psychology</topic><topic>Severity of Illness Index</topic><topic>Verbal Learning - physiology</topic><topic>Working memory</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Ortega, Itxaso</creatorcontrib><creatorcontrib>de los Mozos, Vanesa</creatorcontrib><creatorcontrib>Echeburúa, Enrique</creatorcontrib><creatorcontrib>Mezo, Maria</creatorcontrib><creatorcontrib>Besga, Ariadna</creatorcontrib><creatorcontrib>Ruiz de Azúa, Sonia</creatorcontrib><creatorcontrib>González-Pinto, Asunción</creatorcontrib><creatorcontrib>Gutierrez, Miguel</creatorcontrib><creatorcontrib>Zorrilla, Iñaki</creatorcontrib><creatorcontrib>González-Pinto, Ana</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Ortega, Itxaso</au><au>de los Mozos, Vanesa</au><au>Echeburúa, Enrique</au><au>Mezo, Maria</au><au>Besga, Ariadna</au><au>Ruiz de Azúa, Sonia</au><au>González-Pinto, Asunción</au><au>Gutierrez, Miguel</au><au>Zorrilla, Iñaki</au><au>González-Pinto, Ana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-03-30</date><risdate>2013</risdate><volume>206</volume><issue>1</issue><spage>8</spage><epage>16</epage><pages>8-16</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract The relationship of neurocognitive course with clinical and functional outcomes in psychosis is not well known, especially in the long term. The aim of the study was to examine the clinical and neuropsychological course of first-episode psychosis patients at 5-year follow-up and analyze the relationship of cognitive performance with clinical and functional outcome. The 5-year follow-up was conducted with 26 first-episode psychosis patients. Psychotic symptoms were measured by the Positive and Negative Syndrome Scale, manic and depressive symptoms by the Young Mania Rating Scale and Hamilton Depression Rating Scale respectively, and psychosocial functioning by the Functioning Assessment Short Test. The cognitive domains were assessed by the Wechsler Adult Intelligence Scale, the Wisconsin Card Sorting Test, the Trail Making Test, the Verbal Fluency Test, the Stroop Colour–Word Test and the Wechsler Memory Scale. Patients showed symptomatic improvement in the follow-up except in negative psychotic symptoms. There was also improvement in most cognitive domains except in working memory and processing speed in the follow-up. Working memory impairment was associated to negative psychotic symptoms and poor functional outcomes. Negative symptoms mediated the relationship between working memory and outcome. Therefore, negative symptoms should be a primary target of treatment to improve functional outcomes.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>22985548</pmid><doi>10.1016/j.psychres.2012.08.025</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Attention - physiology Biological and medical sciences Cognition Cognition Disorders - diagnosis Cognition Disorders - etiology Executive Function - physiology Female First episode psychosis Follow-up Functional outcome Humans Longitudinal Studies Male Medical sciences Memory Disorders - diagnosis Memory Disorders - etiology Memory, Short-Term - physiology Negative symptoms Neuropsychological Tests Other psychotic disorders Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - complications Psychotic Disorders - diagnosis Psychotic Disorders - psychology Severity of Illness Index Verbal Learning - physiology Working memory Young Adult |
| title | Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis |
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