Infection of Chickens Caused by Avian Influenza Virus A/H5N1 Delivered by Aerosol and Other Routes
Summary This study presents results of the study of infectivity of avian influenza virus (AIV) A subtype H5N1 strains isolated from agricultural birds across the territory of the Russian Federation and CIS countries. The results of the susceptibility of chickens to the AIV isolates delivered by the...
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| Veröffentlicht in: | Transboundary and emerging diseases 2013-04, Vol.60 (2), p.159-165 |
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| creator | Sergeev, Ar. A. Demina, O. K. Pyankov, O. V. Pyankova, O. G. Agafonov, A. P. Kiselev, S. A. Agranovski, I. E. Sergeev, Al. A. Shikov, A. N. Shishkina, L. N. Safatov, A. S. Sergeev, A. N. |
| description | Summary
This study presents results of the study of infectivity of avian influenza virus (AIV) A subtype H5N1 strains isolated from agricultural birds across the territory of the Russian Federation and CIS countries. The results of the susceptibility of chickens to the AIV isolates delivered by the aerosol route and the dissemination of the virus in the organs of infected birds are presented. As was observed, the sensitivity of birds to AIV by the aerosol route of infection is 30 times higher than by intranasal route, 500 times higher than by the oral route and 10 000 times higher than by the intragastric route of infection, which is indicative of higher permissivity of respiratory organs to AIV. The highest titres of AIV A subtype H5N1(A/Chicken/Kurgan/05/2005 strain) in aerosol‐infected chickens were found in nasal cavity mucosa, lungs, cloaca, serum and kidney, where viable virus accumulation was detected by 18 h post‐infection (p.i.). The highest virus titres were observed 54 h p.i. in lungs, serum and kidney, reaching the value of 8.16 lg EID50/g(ml) in the lungs. The results showed that birds infected by the aerosol route developed higher titres of virus than those infected by other routes. |
| doi_str_mv | 10.1111/j.1865-1682.2012.01329.x |
| format | Article |
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This study presents results of the study of infectivity of avian influenza virus (AIV) A subtype H5N1 strains isolated from agricultural birds across the territory of the Russian Federation and CIS countries. The results of the susceptibility of chickens to the AIV isolates delivered by the aerosol route and the dissemination of the virus in the organs of infected birds are presented. As was observed, the sensitivity of birds to AIV by the aerosol route of infection is 30 times higher than by intranasal route, 500 times higher than by the oral route and 10 000 times higher than by the intragastric route of infection, which is indicative of higher permissivity of respiratory organs to AIV. The highest titres of AIV A subtype H5N1(A/Chicken/Kurgan/05/2005 strain) in aerosol‐infected chickens were found in nasal cavity mucosa, lungs, cloaca, serum and kidney, where viable virus accumulation was detected by 18 h post‐infection (p.i.). The highest virus titres were observed 54 h p.i. in lungs, serum and kidney, reaching the value of 8.16 lg EID50/g(ml) in the lungs. The results showed that birds infected by the aerosol route developed higher titres of virus than those infected by other routes.</description><identifier>ISSN: 1865-1674</identifier><identifier>EISSN: 1865-1682</identifier><identifier>DOI: 10.1111/j.1865-1682.2012.01329.x</identifier><identifier>PMID: 22494627</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>A/H5N1 aerosol infecting dose ; Administration, Intranasal ; Administration, Oral ; Aerosols ; Animals ; Avian flu ; Avian influenza ; Chickens - virology ; Disease transmission ; Gastrointestinal Tract - virology ; Influenza A Virus, H5N1 Subtype - isolation & purification ; Influenza A Virus, H5N1 Subtype - pathogenicity ; Influenza in Birds - pathology ; Influenza in Birds - virology ; Kidney - pathology ; Kidney - virology ; Lung - pathology ; Lung - virology ; Poultry ; respiratory transmission ; Russia ; Virology</subject><ispartof>Transboundary and emerging diseases, 2013-04, Vol.60 (2), p.159-165</ispartof><rights>2012 Blackwell Verlag GmbH</rights><rights>2012 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3879-3d2ccc8619318bfdd97fe958383d55329017e89cab615e6b4b100983433eacc53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1865-1682.2012.01329.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1865-1682.2012.01329.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22494627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sergeev, Ar. A.</creatorcontrib><creatorcontrib>Demina, O. K.</creatorcontrib><creatorcontrib>Pyankov, O. V.</creatorcontrib><creatorcontrib>Pyankova, O. G.</creatorcontrib><creatorcontrib>Agafonov, A. P.</creatorcontrib><creatorcontrib>Kiselev, S. A.</creatorcontrib><creatorcontrib>Agranovski, I. E.</creatorcontrib><creatorcontrib>Sergeev, Al. A.</creatorcontrib><creatorcontrib>Shikov, A. N.</creatorcontrib><creatorcontrib>Shishkina, L. N.</creatorcontrib><creatorcontrib>Safatov, A. S.</creatorcontrib><creatorcontrib>Sergeev, A. N.</creatorcontrib><title>Infection of Chickens Caused by Avian Influenza Virus A/H5N1 Delivered by Aerosol and Other Routes</title><title>Transboundary and emerging diseases</title><addtitle>Transbound Emerg Dis</addtitle><description>Summary
This study presents results of the study of infectivity of avian influenza virus (AIV) A subtype H5N1 strains isolated from agricultural birds across the territory of the Russian Federation and CIS countries. The results of the susceptibility of chickens to the AIV isolates delivered by the aerosol route and the dissemination of the virus in the organs of infected birds are presented. As was observed, the sensitivity of birds to AIV by the aerosol route of infection is 30 times higher than by intranasal route, 500 times higher than by the oral route and 10 000 times higher than by the intragastric route of infection, which is indicative of higher permissivity of respiratory organs to AIV. The highest titres of AIV A subtype H5N1(A/Chicken/Kurgan/05/2005 strain) in aerosol‐infected chickens were found in nasal cavity mucosa, lungs, cloaca, serum and kidney, where viable virus accumulation was detected by 18 h post‐infection (p.i.). The highest virus titres were observed 54 h p.i. in lungs, serum and kidney, reaching the value of 8.16 lg EID50/g(ml) in the lungs. The results showed that birds infected by the aerosol route developed higher titres of virus than those infected by other routes.</description><subject>A/H5N1 aerosol infecting dose</subject><subject>Administration, Intranasal</subject><subject>Administration, Oral</subject><subject>Aerosols</subject><subject>Animals</subject><subject>Avian flu</subject><subject>Avian influenza</subject><subject>Chickens - virology</subject><subject>Disease transmission</subject><subject>Gastrointestinal Tract - virology</subject><subject>Influenza A Virus, H5N1 Subtype - isolation & purification</subject><subject>Influenza A Virus, H5N1 Subtype - pathogenicity</subject><subject>Influenza in Birds - pathology</subject><subject>Influenza in Birds - virology</subject><subject>Kidney - pathology</subject><subject>Kidney - virology</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Poultry</subject><subject>respiratory transmission</subject><subject>Russia</subject><subject>Virology</subject><issn>1865-1674</issn><issn>1865-1682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EoqXwF5AlLlyS-iP-yAVp2ZZtpaUVqHyIi-U4E9XbbFLspOz219dhlz0wF480j16N50EIU5LTVKernGopMio1yxmhLCeUszLfPEPHh8HzQ6-KI_QqxhUhkpRSvERHjBVlIZk6RtVl14AbfN_hvsHzW-_uoIt4bscINa62ePbgbYcT1Y7QPVr83Ycx4tnphbii-Axa_wBhT0LoY99i29X4eriFgL_24wDxNXrR2DbCm_17gr59Or-ZX2TL68XlfLbMHNeqzHjNnHNa0pJTXTV1XaoGSqG55rUQ6XuEKtCls5WkAmRVVJSQUvOCc7DOCX6C3u9y70P_e4Q4mLWPDtrWdtCP0VBOheS8oDyh7_5DV_0YurTdRKl0HKZIot7uqbFaQ23ug1_bsDX_rpeADzvgj29he5hTYiZLZmUmAWaSYSZL5q8lszE3H8_PpjYFZLsAHwfYHAJsuDNScSXMj6uFWaifX5a_xGfD-ROfHZH4</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Sergeev, Ar. A.</creator><creator>Demina, O. K.</creator><creator>Pyankov, O. V.</creator><creator>Pyankova, O. G.</creator><creator>Agafonov, A. P.</creator><creator>Kiselev, S. A.</creator><creator>Agranovski, I. E.</creator><creator>Sergeev, Al. A.</creator><creator>Shikov, A. N.</creator><creator>Shishkina, L. N.</creator><creator>Safatov, A. S.</creator><creator>Sergeev, A. N.</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Infection of Chickens Caused by Avian Influenza Virus A/H5N1 Delivered by Aerosol and Other Routes</title><author>Sergeev, Ar. A. ; Demina, O. K. ; Pyankov, O. V. ; Pyankova, O. G. ; Agafonov, A. P. ; Kiselev, S. A. ; Agranovski, I. E. ; Sergeev, Al. A. ; Shikov, A. N. ; Shishkina, L. N. ; Safatov, A. S. ; Sergeev, A. 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A.</creatorcontrib><creatorcontrib>Demina, O. K.</creatorcontrib><creatorcontrib>Pyankov, O. V.</creatorcontrib><creatorcontrib>Pyankova, O. G.</creatorcontrib><creatorcontrib>Agafonov, A. P.</creatorcontrib><creatorcontrib>Kiselev, S. A.</creatorcontrib><creatorcontrib>Agranovski, I. E.</creatorcontrib><creatorcontrib>Sergeev, Al. A.</creatorcontrib><creatorcontrib>Shikov, A. N.</creatorcontrib><creatorcontrib>Shishkina, L. N.</creatorcontrib><creatorcontrib>Safatov, A. S.</creatorcontrib><creatorcontrib>Sergeev, A. N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transboundary and emerging diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sergeev, Ar. A.</au><au>Demina, O. K.</au><au>Pyankov, O. V.</au><au>Pyankova, O. G.</au><au>Agafonov, A. P.</au><au>Kiselev, S. A.</au><au>Agranovski, I. E.</au><au>Sergeev, Al. A.</au><au>Shikov, A. N.</au><au>Shishkina, L. N.</au><au>Safatov, A. S.</au><au>Sergeev, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infection of Chickens Caused by Avian Influenza Virus A/H5N1 Delivered by Aerosol and Other Routes</atitle><jtitle>Transboundary and emerging diseases</jtitle><addtitle>Transbound Emerg Dis</addtitle><date>2013-04</date><risdate>2013</risdate><volume>60</volume><issue>2</issue><spage>159</spage><epage>165</epage><pages>159-165</pages><issn>1865-1674</issn><eissn>1865-1682</eissn><abstract>Summary
This study presents results of the study of infectivity of avian influenza virus (AIV) A subtype H5N1 strains isolated from agricultural birds across the territory of the Russian Federation and CIS countries. The results of the susceptibility of chickens to the AIV isolates delivered by the aerosol route and the dissemination of the virus in the organs of infected birds are presented. As was observed, the sensitivity of birds to AIV by the aerosol route of infection is 30 times higher than by intranasal route, 500 times higher than by the oral route and 10 000 times higher than by the intragastric route of infection, which is indicative of higher permissivity of respiratory organs to AIV. The highest titres of AIV A subtype H5N1(A/Chicken/Kurgan/05/2005 strain) in aerosol‐infected chickens were found in nasal cavity mucosa, lungs, cloaca, serum and kidney, where viable virus accumulation was detected by 18 h post‐infection (p.i.). The highest virus titres were observed 54 h p.i. in lungs, serum and kidney, reaching the value of 8.16 lg EID50/g(ml) in the lungs. The results showed that birds infected by the aerosol route developed higher titres of virus than those infected by other routes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22494627</pmid><doi>10.1111/j.1865-1682.2012.01329.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | A/H5N1 aerosol infecting dose Administration, Intranasal Administration, Oral Aerosols Animals Avian flu Avian influenza Chickens - virology Disease transmission Gastrointestinal Tract - virology Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Influenza in Birds - pathology Influenza in Birds - virology Kidney - pathology Kidney - virology Lung - pathology Lung - virology Poultry respiratory transmission Russia Virology |
| title | Infection of Chickens Caused by Avian Influenza Virus A/H5N1 Delivered by Aerosol and Other Routes |
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