Trafficking of the IKs‐Complex in MDCK Cells: Site of Subunit Assembly and Determinants of Polarized Localization

The voltage‐gated potassium channel KV7.1 is regulated by non‐pore forming regulatory KCNE β‐subunits. Together with KCNE1, it forms the slowly activating delayed rectifier potassium current IKs. However, where the subunits assemble and which of the subunits determines localization of the IKs‐comple...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2013-04, Vol.14 (4), p.399-411
Hauptverfasser:	David, Jens‐Peter, Andersen, Martin N., Olesen, Søren‐Peter, Rasmussen, Hanne B., Schmitt, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - metabolism Cells Dogs Endoplasmic Reticulum - metabolism Golgi Apparatus - metabolism KCNE1 KCNQ1 KCNQ1 Potassium Channel - chemistry KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism LQT Madin Darby Canine Kidney Cells MDCK Mutation, Missense Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Protein Interaction Domains and Motifs Protein Multimerization Protein Sorting Signals - genetics Protein Subunits - genetics Protein Subunits - metabolism Protein Transport Proteins Rab1 Secretory Pathway trafficking
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