The effect of hyperoside on the functional recovery of the ischemic/reperfused isolated rat heart: Potential involvement of the extracellular signal-regulated kinase 1/2 signaling pathway

One of the leading causes of death in the world is ischemia/reperfusion (I/R)-mediated acute myocardial infarction. There are a lot of Chinese traditional patent medicines, such as Xin'an capsules, Xin Xuening tablets, and so on, which have protective effects against myocardial I/R injury and h...

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Veröffentlicht in:	Free radical biology & medicine 2013-04, Vol.57, p.132-140
Hauptverfasser:	Li, Zi-lin, Hu, Jing, Li, Ya-ling, Xue, Feng, Zhang, Li, Xie, Jia-qi, Liu, Zhen-hua, Li, Hua, Yi, Ding-hua, Liu, Jin-cheng, Wang, Si-wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac output Cardiac Surgical Procedures cardiomyocytes Cardioprotection Caspase 3 - metabolism creatine kinase Creatine Kinase - analysis death ERK1/2 Flavonoids - pharmacology Free radicals Hyperoside infarction Ischemia/reperfusion injury L-Lactate Dehydrogenase - analysis lactate dehydrogenase Langendorff Male malondialdehyde Malondialdehyde - analysis MAP Kinase Signaling System mitogen-activated protein kinase Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Myocardial Contraction myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - drug therapy myocardium Myocytes, Cardiac - metabolism oxidative stress Oxidative Stress - drug effects Phosphorylation protective effect Protein Kinase Inhibitors - pharmacology Quercetin - analogs & derivatives Quercetin - pharmacology Rats Rats, Sprague-Dawley signal transduction superoxide dismutase Superoxide Dismutase - analysis Western blotting
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