Characterization of a refinement of the “pylorus ligation” model of rat gastric ulceration resulting in “no pain” and a more specific pharmacological response

The pharmacological assessment of the factors for gastric protection of a test substance should involve experimental models that can determine the involvement of cytoprotective factors, as well as their influence on the secretion of hydrochloric acid. The original protocol of pylorus ligation in rat...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2013-03, Vol.67 (2), p.121-128
Hauptverfasser:	Monteiro, Karin M., Spindola, Humberto M., Possenti, Ana, Tinti, Sirlene V., Ruiz, Ana L.T.G., Longato, Giovanna B., Fiorito, Giovanna F., Marchetti, Gabriela M., Shiozawa, Larissa, Piloni, Bárbara U., de Oliveira, Ana C., Miyagawa, Livia M., Carvalho, João E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Bethanechol - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Gastric Acid - secretion Gastric secretion Histamine - pharmacology Ligation Male Pain, Postoperative - physiopathology Pain, Postoperative - prevention & control Pentagastrin - pharmacology Pylorus - surgery Pylorus ligation Rats Rats, Wistar Refinement Sensitivity and Specificity Stomach - drug effects Stomach - metabolism Stomach Ulcer - chemically induced Stomach Ulcer - metabolism Stomach Ulcer - pathology Stress Stress, Physiological - physiology
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