Intraperitoneal medetomidine: A novel analgesic strategy for postoperative pain management in pregnant sheep
The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic...
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| Veröffentlicht in: | Laboratory animals (London) 2013-01, Vol.47 (1), p.66-70 |
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| creator | Murdoch, F R Maker, G L Nitsos, I Polglase, G R Musk, G C |
| description | The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 μL/h (3 μg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 μg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation. |
| doi_str_mv | 10.1177/0023677212473712 |
| format | Article |
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Delivery of 3 μg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.</description><identifier>ISSN: 0023-6772</identifier><identifier>EISSN: 1758-1117</identifier><identifier>DOI: 10.1177/0023677212473712</identifier><identifier>PMID: 23467491</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Analgesia - methods ; Analgesia - veterinary ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - therapeutic use ; Animals ; Female ; Infusions, Parenteral - veterinary ; Medetomidine - administration & dosage ; Medetomidine - therapeutic use ; Pain Management - methods ; Pain Management - veterinary ; Pain, Postoperative - drug therapy ; Pregnancy ; Sheep - surgery</subject><ispartof>Laboratory animals (London), 2013-01, Vol.47 (1), p.66-70</ispartof><rights>2013 Laboratory Animals Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-9eadc9012f023a4127bfb012fa67c5c45a5a3a24169f3f9bb1b6f2ec0925db583</citedby><cites>FETCH-LOGICAL-c337t-9eadc9012f023a4127bfb012fa67c5c45a5a3a24169f3f9bb1b6f2ec0925db583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23467491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murdoch, F R</creatorcontrib><creatorcontrib>Maker, G L</creatorcontrib><creatorcontrib>Nitsos, I</creatorcontrib><creatorcontrib>Polglase, G R</creatorcontrib><creatorcontrib>Musk, G C</creatorcontrib><title>Intraperitoneal medetomidine: A novel analgesic strategy for postoperative pain management in pregnant sheep</title><title>Laboratory animals (London)</title><addtitle>Lab Anim</addtitle><description>The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 μL/h (3 μg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 μg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.</description><subject>Analgesia - methods</subject><subject>Analgesia - veterinary</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Animals</subject><subject>Female</subject><subject>Infusions, Parenteral - veterinary</subject><subject>Medetomidine - administration & dosage</subject><subject>Medetomidine - therapeutic use</subject><subject>Pain Management - methods</subject><subject>Pain Management - veterinary</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pregnancy</subject><subject>Sheep - surgery</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAcxYMobk7vniRHL9X8aJvV2xj-GAy86Lmk7Tc1o01qkg7235sy9SCYS_J4n_cID6FrSu4oFeKeEMZzIRhlqeCCshM0pyJbJjS6p2g-2cnkz9CF97soabok52jGeJqLtKBz1G1McHIAp4M1IDvcQwPB9rrRBh7wChu7hw5LI7sWvK6xj3iA9oCVdXiwPtgYlkHvAQ9SG9xHtIUeTMBRDQ5aI-PbfwAMl-hMyc7D1fe9QO9Pj2_rl2T7-rxZr7ZJzbkISQGyqQtCmYr_lyllolLVJGUu6qxOM5lJLllK80JxVVQVrXLFoCYFy5oqW_IFuj32Ds5-juBD2WtfQ9dJA3b0JeU0y9kynoiSI1o7670DVQ5O99IdSkrKaePy78YxcvPdPlZxrd_Az6gRSI6Aj0uUOzu6uJ7_v_ALGvWFkg</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Murdoch, F R</creator><creator>Maker, G L</creator><creator>Nitsos, I</creator><creator>Polglase, G R</creator><creator>Musk, G C</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Intraperitoneal medetomidine: A novel analgesic strategy for postoperative pain management in pregnant sheep</title><author>Murdoch, F R ; Maker, G L ; Nitsos, I ; Polglase, G R ; Musk, G C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-9eadc9012f023a4127bfb012fa67c5c45a5a3a24169f3f9bb1b6f2ec0925db583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analgesia - methods</topic><topic>Analgesia - veterinary</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Animals</topic><topic>Female</topic><topic>Infusions, Parenteral - veterinary</topic><topic>Medetomidine - administration & dosage</topic><topic>Medetomidine - therapeutic use</topic><topic>Pain Management - methods</topic><topic>Pain Management - veterinary</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pregnancy</topic><topic>Sheep - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murdoch, F R</creatorcontrib><creatorcontrib>Maker, G L</creatorcontrib><creatorcontrib>Nitsos, I</creatorcontrib><creatorcontrib>Polglase, G R</creatorcontrib><creatorcontrib>Musk, G C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murdoch, F R</au><au>Maker, G L</au><au>Nitsos, I</au><au>Polglase, G R</au><au>Musk, G C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraperitoneal medetomidine: A novel analgesic strategy for postoperative pain management in pregnant sheep</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>2013-01</date><risdate>2013</risdate><volume>47</volume><issue>1</issue><spage>66</spage><epage>70</epage><pages>66-70</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 μL/h (3 μg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 μg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23467491</pmid><doi>10.1177/0023677212473712</doi><tpages>5</tpages></addata></record> |
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| subjects | Analgesia - methods Analgesia - veterinary Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - therapeutic use Animals Female Infusions, Parenteral - veterinary Medetomidine - administration & dosage Medetomidine - therapeutic use Pain Management - methods Pain Management - veterinary Pain, Postoperative - drug therapy Pregnancy Sheep - surgery |
| title | Intraperitoneal medetomidine: A novel analgesic strategy for postoperative pain management in pregnant sheep |
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