Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9

It was recently suggested that bone morphogenetic protein (BMP)-2 may be useful for treating osteosarcoma cells. BMP-9, which has been patented to treat breast and prostate cancers, has a higher osteoinductive potential than BMP-2. Peptides derived from the knuckle epitope of BMPs (pBMPs) also induc...

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Veröffentlicht in:	Anti-cancer drugs 2013-03, Vol.24 (3), p.278-290
Hauptverfasser:	Park, Hyunjin, Drevelle, Olivier, Daviau, Alex, Senta, Helena, Bergeron, Eric, Faucheux, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bone Morphogenetic Protein 2 - pharmacology Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Dose-Response Relationship, Drug Flavonoids - pharmacology Gene Expression Regulation, Neoplastic - drug effects Growth Differentiation Factor 2 - pharmacology Homeodomain Proteins - genetics Humans MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Molecular Sequence Data Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Peptide Fragments - pharmacology Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Smad Proteins - metabolism Sp7 Transcription Factor Transcription Factors - genetics
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