Molecular Characterization of HIV Type 1 in Brazzaville, Republic of Congo, and First Data on Resistance to Antiretroviral Drugs
One hundred patients have been enrolled in the CTA (ambulatory treatment center) of Brazzaville, Republic of Congo, from February to April 2011: 41 naive individuals and 59 patients at failure of first line regimen [two nucleoside reverse transcriptase inhibitors (NRTIs) plus one nonnucleoside rever...
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| Veröffentlicht in: | AIDS research and human retroviruses 2012-12, Vol.28 (12), p.1798-1802 |
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| creator | PIRCHER, Mathilde DIAFOUKA, Merlin PAPUCHON, Jennifer RECORDON-PINSON, Patricia NSONDE MAHAMBOU, Dominique AKOLBOUT, Maryse SIMON, Bernard FLEURY, Hervé |
| description | One hundred patients have been enrolled in the CTA (ambulatory treatment center) of Brazzaville, Republic of Congo, from February to April 2011: 41 naive individuals and 59 patients at failure of first line regimen [two nucleoside reverse transcriptase inhibitors (NRTIs) plus one nonnucleoside reverse transcriptase inhibitor (NNRTI)]. Phylogenetic analysis of HIV-1 isolates allowed identification of subtypes and circulating recombinant forms (CRFs). The drug resistance mutations (DRMs) in reverse transcriptase and protease were analyzed in both subpopulations. Globally, 92 viruses were characterized, exhibiting a high diversity of HIV-1 with a majority of undetermined recombinant forms (URF) followed by CRF02_AG, CRF37_cpx, G, A1, B, D, H, and several other subtypes and CRF: F1, A2, C, CRF13_cpx, CRF11_cpx, CRF20_BG, CRF21_A2D, CRF33_01B G, CRF02_AG, CRF37_cpx, and A1. In naive patients, DRMs were observed with percentages ranging from 4% to 9% depending on drug classes. In treated patients at failure, numerous DRMs could be noted that induce actual or potential resistance to major NRTIs and NNRTIs. |
| doi_str_mv | 10.1089/aid.2012.0083 |
| format | Article |
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Phylogenetic analysis of HIV-1 isolates allowed identification of subtypes and circulating recombinant forms (CRFs). The drug resistance mutations (DRMs) in reverse transcriptase and protease were analyzed in both subpopulations. Globally, 92 viruses were characterized, exhibiting a high diversity of HIV-1 with a majority of undetermined recombinant forms (URF) followed by CRF02_AG, CRF37_cpx, G, A1, B, D, H, and several other subtypes and CRF: F1, A2, C, CRF13_cpx, CRF11_cpx, CRF20_BG, CRF21_A2D, CRF33_01B G, CRF02_AG, CRF37_cpx, and A1. In naive patients, DRMs were observed with percentages ranging from 4% to 9% depending on drug classes. In treated patients at failure, numerous DRMs could be noted that induce actual or potential resistance to major NRTIs and NNRTIs.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2012.0083</identifier><identifier>PMID: 22697883</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>Adult ; Aged ; AIDS/HIV ; Anti-Retroviral Agents - pharmacology ; Antiviral agents ; Biological and medical sciences ; Cluster Analysis ; Congo ; Corticotropin-releasing hormone ; Data processing ; DRM protein ; Drug resistance ; Drug Resistance, Viral ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; Genotype ; HIV Infections - virology ; HIV Protease - genetics ; HIV Reverse Transcriptase - genetics ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Sequence Data ; Mutation ; non-nucleoside reverse transcriptase inhibitors ; nucleoside reverse transcriptase inhibitors ; Phylogeny ; Proteinase ; Retrovirus ; RNA-directed DNA polymerase ; Sequence Analysis, DNA ; Subpopulations ; Viral diseases ; Virology ; Young Adult</subject><ispartof>AIDS research and human retroviruses, 2012-12, Vol.28 (12), p.1798-1802</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d282ceb60810958b0b454d00bb57613a572112736ddad7a71bfe7cda602541393</citedby><cites>FETCH-LOGICAL-c356t-d282ceb60810958b0b454d00bb57613a572112736ddad7a71bfe7cda602541393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26673497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22697883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PIRCHER, Mathilde</creatorcontrib><creatorcontrib>DIAFOUKA, Merlin</creatorcontrib><creatorcontrib>PAPUCHON, Jennifer</creatorcontrib><creatorcontrib>RECORDON-PINSON, Patricia</creatorcontrib><creatorcontrib>NSONDE MAHAMBOU, Dominique</creatorcontrib><creatorcontrib>AKOLBOUT, Maryse</creatorcontrib><creatorcontrib>SIMON, Bernard</creatorcontrib><creatorcontrib>FLEURY, Hervé</creatorcontrib><title>Molecular Characterization of HIV Type 1 in Brazzaville, Republic of Congo, and First Data on Resistance to Antiretroviral Drugs</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>One hundred patients have been enrolled in the CTA (ambulatory treatment center) of Brazzaville, Republic of Congo, from February to April 2011: 41 naive individuals and 59 patients at failure of first line regimen [two nucleoside reverse transcriptase inhibitors (NRTIs) plus one nonnucleoside reverse transcriptase inhibitor (NNRTI)]. Phylogenetic analysis of HIV-1 isolates allowed identification of subtypes and circulating recombinant forms (CRFs). The drug resistance mutations (DRMs) in reverse transcriptase and protease were analyzed in both subpopulations. Globally, 92 viruses were characterized, exhibiting a high diversity of HIV-1 with a majority of undetermined recombinant forms (URF) followed by CRF02_AG, CRF37_cpx, G, A1, B, D, H, and several other subtypes and CRF: F1, A2, C, CRF13_cpx, CRF11_cpx, CRF20_BG, CRF21_A2D, CRF33_01B G, CRF02_AG, CRF37_cpx, and A1. In naive patients, DRMs were observed with percentages ranging from 4% to 9% depending on drug classes. In treated patients at failure, numerous DRMs could be noted that induce actual or potential resistance to major NRTIs and NNRTIs.</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Anti-Retroviral Agents - pharmacology</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Cluster Analysis</subject><subject>Congo</subject><subject>Corticotropin-releasing hormone</subject><subject>Data processing</subject><subject>DRM protein</subject><subject>Drug resistance</subject><subject>Drug Resistance, Viral</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>HIV Infections - virology</subject><subject>HIV Protease - genetics</subject><subject>HIV Reverse Transcriptase - genetics</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>non-nucleoside reverse transcriptase inhibitors</subject><subject>nucleoside reverse transcriptase inhibitors</subject><subject>Phylogeny</subject><subject>Proteinase</subject><subject>Retrovirus</subject><subject>RNA-directed DNA polymerase</subject><subject>Sequence Analysis, DNA</subject><subject>Subpopulations</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0TtvFDEUhmELgcgSKGmRGySKzOLL-FaGDblIQUhRoB2dsT3ByDtebE-kbMVPZ0bZQEl1mkdfcV6E3lKypkSbjxDcmhHK1oRo_gytqOG00S0Rz9GKaG0axpg5Qq9K-UkIMYyJl-iIMWmU1nyFfn9J0dspQsabH5DBVp_DHmpII04Dvrz6jm8fdh5THEb8KcN-D_chRn-Cb_xu6mOwC9uk8S6dYBgdPg-5VHwGFfA8ceNLKBVG63FN-HSsIfua033IEPFZnu7Ka_RigFj8m8M9Rt_OP99uLpvrrxdXm9PrxnIha-OYZtb3kmhKjNA96VvROkL6XihJOQjFKGWKS-fAKVC0H7yyDiRhoqXc8GP04XF3l9OvyZfabUOxPkYYfZpKRzkVkgki9f8pNarVzLBltXmkNqdSsh-6XQ5byA8dJd3Sp5v7dEufbukz-3eH6anfevdXPwWZwfsDgGIhDnn-XSj_nJSKt0bxP3-wl1I</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>PIRCHER, Mathilde</creator><creator>DIAFOUKA, Merlin</creator><creator>PAPUCHON, Jennifer</creator><creator>RECORDON-PINSON, Patricia</creator><creator>NSONDE MAHAMBOU, Dominique</creator><creator>AKOLBOUT, Maryse</creator><creator>SIMON, Bernard</creator><creator>FLEURY, Hervé</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20121201</creationdate><title>Molecular Characterization of HIV Type 1 in Brazzaville, Republic of Congo, and First Data on Resistance to Antiretroviral Drugs</title><author>PIRCHER, Mathilde ; DIAFOUKA, Merlin ; PAPUCHON, Jennifer ; RECORDON-PINSON, Patricia ; NSONDE MAHAMBOU, Dominique ; AKOLBOUT, Maryse ; SIMON, Bernard ; FLEURY, Hervé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d282ceb60810958b0b454d00bb57613a572112736ddad7a71bfe7cda602541393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Anti-Retroviral Agents - pharmacology</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Cluster Analysis</topic><topic>Congo</topic><topic>Corticotropin-releasing hormone</topic><topic>Data processing</topic><topic>DRM protein</topic><topic>Drug resistance</topic><topic>Drug Resistance, Viral</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>HIV Infections - virology</topic><topic>HIV Protease - genetics</topic><topic>HIV Reverse Transcriptase - genetics</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>non-nucleoside reverse transcriptase inhibitors</topic><topic>nucleoside reverse transcriptase inhibitors</topic><topic>Phylogeny</topic><topic>Proteinase</topic><topic>Retrovirus</topic><topic>RNA-directed DNA polymerase</topic><topic>Sequence Analysis, DNA</topic><topic>Subpopulations</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PIRCHER, Mathilde</creatorcontrib><creatorcontrib>DIAFOUKA, Merlin</creatorcontrib><creatorcontrib>PAPUCHON, Jennifer</creatorcontrib><creatorcontrib>RECORDON-PINSON, Patricia</creatorcontrib><creatorcontrib>NSONDE MAHAMBOU, Dominique</creatorcontrib><creatorcontrib>AKOLBOUT, Maryse</creatorcontrib><creatorcontrib>SIMON, Bernard</creatorcontrib><creatorcontrib>FLEURY, Hervé</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PIRCHER, Mathilde</au><au>DIAFOUKA, Merlin</au><au>PAPUCHON, Jennifer</au><au>RECORDON-PINSON, Patricia</au><au>NSONDE MAHAMBOU, Dominique</au><au>AKOLBOUT, Maryse</au><au>SIMON, Bernard</au><au>FLEURY, Hervé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Characterization of HIV Type 1 in Brazzaville, Republic of Congo, and First Data on Resistance to Antiretroviral Drugs</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>28</volume><issue>12</issue><spage>1798</spage><epage>1802</epage><pages>1798-1802</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>One hundred patients have been enrolled in the CTA (ambulatory treatment center) of Brazzaville, Republic of Congo, from February to April 2011: 41 naive individuals and 59 patients at failure of first line regimen [two nucleoside reverse transcriptase inhibitors (NRTIs) plus one nonnucleoside reverse transcriptase inhibitor (NNRTI)]. Phylogenetic analysis of HIV-1 isolates allowed identification of subtypes and circulating recombinant forms (CRFs). The drug resistance mutations (DRMs) in reverse transcriptase and protease were analyzed in both subpopulations. Globally, 92 viruses were characterized, exhibiting a high diversity of HIV-1 with a majority of undetermined recombinant forms (URF) followed by CRF02_AG, CRF37_cpx, G, A1, B, D, H, and several other subtypes and CRF: F1, A2, C, CRF13_cpx, CRF11_cpx, CRF20_BG, CRF21_A2D, CRF33_01B G, CRF02_AG, CRF37_cpx, and A1. In naive patients, DRMs were observed with percentages ranging from 4% to 9% depending on drug classes. In treated patients at failure, numerous DRMs could be noted that induce actual or potential resistance to major NRTIs and NNRTIs.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>22697883</pmid><doi>10.1089/aid.2012.0083</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged AIDS/HIV Anti-Retroviral Agents - pharmacology Antiviral agents Biological and medical sciences Cluster Analysis Congo Corticotropin-releasing hormone Data processing DRM protein Drug resistance Drug Resistance, Viral Female Fundamental and applied biological sciences. Psychology Genetic Variation Genotype HIV Infections - virology HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - classification HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Sequence Data Mutation non-nucleoside reverse transcriptase inhibitors nucleoside reverse transcriptase inhibitors Phylogeny Proteinase Retrovirus RNA-directed DNA polymerase Sequence Analysis, DNA Subpopulations Viral diseases Virology Young Adult |
| title | Molecular Characterization of HIV Type 1 in Brazzaville, Republic of Congo, and First Data on Resistance to Antiretroviral Drugs |
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