Fertility in male patients with seronegative spondyloarthropathies treated with infliximab
Abstract Objectives The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment...
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| Veröffentlicht in: | Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2013-01, Vol.80 (1), p.34-37 |
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| creator | Saougou, Ioanna Markatseli, Theodora E Papagoras, Charalampos Kaltsonoudis, Evripidis Voulgari, Paraskevi V Drosos, Alexandros A |
| description | Abstract Objectives The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment for these patients. To identify male patients who achieved pregnancy development during their management with anti-TNFα blockers (infliximab). Methods We reviewed the data of 65 patients with AS and 30 patients with PsA who were followed-up in our rheumatology outpatients clinic and they were on infliximab therapy between January 2001 and December 2010. Results We identified overall seven male patients with AS and three male patients with PsA who had fathered 14 healthy infants. Moreover, we recognized one man with PsA who was on infliximab and on concomitant therapy with MTX at the time of conception, whose wife had to proceed to therapeutic abortion due to congenital abnormalities of the fetus (hydrocephalia), while she was on the first trimester of pregnancy. Conclusions We described male patients with AS and PsA who demonstrated no fertility problems while they were on infliximab treatment. The data designated in this report provide some supportive evidence for the safe use of infliximab in male patients who are affected of those inflammatory diseases during their peak reproductive years. |
| doi_str_mv | 10.1016/j.jbspin.2012.03.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315623994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1297319X12000590</els_id><sourcerecordid>1282839889</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-302d8dab55d632b62cb575db898df064788e90039b47e8f3dda0ede49a28545f3</originalsourceid><addsrcrecordid>eNqFkk2L1TAUhosozof-A5Eu3bTms002ggyOIwy4UEHchDQ59abmJjXJHb3_3lw6unAzq4TwvOecvO9pmhcY9Rjh4fXSL1NeXegJwqRHtEeIPWrO8TiKbiScPa53IseOYvn1rLnIeUEIUcKHp80ZIXzkaBjPm2_XkIrzrhxbF9q99tCuujgIJbe_XNm1GVIM8L2-3UGb1xjs0Uedyi7FCu4c5LYk0AXsxrswe_fb7fX0rHkya5_h-f152Xy5fvf56qa7_fj-w9Xb284wjkpHEbHC6olzO1AyDcRMdTg7CSnsjAY2CgGyTi4nNoKYqbUagQUmNRGc8ZleNq-2umuKPw-Qi9q7bMB7HSAessIU84FQKdnDKBFEUCmErCjbUJNizglmtab6q3RUGKlTAGpRWwDqFIBCVNUAquzlfYfDtAf7T_TX8Qq82QColtw5SCqbarcB6xKYomx0D3X4v4DxLjij_Q84Ql7iIYVqt8IqV436dFqC0w5gUvPnEtE_-bqvXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1282839889</pqid></control><display><type>article</type><title>Fertility in male patients with seronegative spondyloarthropathies treated with infliximab</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Saougou, Ioanna ; Markatseli, Theodora E ; Papagoras, Charalampos ; Kaltsonoudis, Evripidis ; Voulgari, Paraskevi V ; Drosos, Alexandros A</creator><creatorcontrib>Saougou, Ioanna ; Markatseli, Theodora E ; Papagoras, Charalampos ; Kaltsonoudis, Evripidis ; Voulgari, Paraskevi V ; Drosos, Alexandros A</creatorcontrib><description>Abstract Objectives The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment for these patients. To identify male patients who achieved pregnancy development during their management with anti-TNFα blockers (infliximab). Methods We reviewed the data of 65 patients with AS and 30 patients with PsA who were followed-up in our rheumatology outpatients clinic and they were on infliximab therapy between January 2001 and December 2010. Results We identified overall seven male patients with AS and three male patients with PsA who had fathered 14 healthy infants. Moreover, we recognized one man with PsA who was on infliximab and on concomitant therapy with MTX at the time of conception, whose wife had to proceed to therapeutic abortion due to congenital abnormalities of the fetus (hydrocephalia), while she was on the first trimester of pregnancy. Conclusions We described male patients with AS and PsA who demonstrated no fertility problems while they were on infliximab treatment. The data designated in this report provide some supportive evidence for the safe use of infliximab in male patients who are affected of those inflammatory diseases during their peak reproductive years.</description><identifier>ISSN: 1297-319X</identifier><identifier>EISSN: 1778-7254</identifier><identifier>DOI: 10.1016/j.jbspin.2012.03.004</identifier><identifier>PMID: 22575067</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>Abortion ; Adult ; Ankylosing spondylitis ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antibodies, Monoclonal - adverse effects ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal - therapeutic use ; Arthritis ; Data processing ; Development ; Fertility ; Fetuses ; Humans ; Infants ; Infertility, Male - chemically induced ; Inflammatory diseases ; Infliximab ; Internal Medicine ; Joint diseases ; Male ; Male fertility ; Monoclonal antibodies ; Pregnancy ; Psoriatic arthritis ; Rheumatology ; Spermatogenesis - drug effects ; Spine ; Spondylarthropathies - drug therapy ; Spondyloarthropathies ; spondyloarthropathy ; Tumor necrosis factor ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><ispartof>Joint, bone, spine : revue du rhumatisme, 2013-01, Vol.80 (1), p.34-37</ispartof><rights>Société française de rhumatologie</rights><rights>2012 Société française de rhumatologie</rights><rights>Copyright © 2012 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-302d8dab55d632b62cb575db898df064788e90039b47e8f3dda0ede49a28545f3</citedby><cites>FETCH-LOGICAL-c450t-302d8dab55d632b62cb575db898df064788e90039b47e8f3dda0ede49a28545f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbspin.2012.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22575067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saougou, Ioanna</creatorcontrib><creatorcontrib>Markatseli, Theodora E</creatorcontrib><creatorcontrib>Papagoras, Charalampos</creatorcontrib><creatorcontrib>Kaltsonoudis, Evripidis</creatorcontrib><creatorcontrib>Voulgari, Paraskevi V</creatorcontrib><creatorcontrib>Drosos, Alexandros A</creatorcontrib><title>Fertility in male patients with seronegative spondyloarthropathies treated with infliximab</title><title>Joint, bone, spine : revue du rhumatisme</title><addtitle>Joint Bone Spine</addtitle><description>Abstract Objectives The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment for these patients. To identify male patients who achieved pregnancy development during their management with anti-TNFα blockers (infliximab). Methods We reviewed the data of 65 patients with AS and 30 patients with PsA who were followed-up in our rheumatology outpatients clinic and they were on infliximab therapy between January 2001 and December 2010. Results We identified overall seven male patients with AS and three male patients with PsA who had fathered 14 healthy infants. Moreover, we recognized one man with PsA who was on infliximab and on concomitant therapy with MTX at the time of conception, whose wife had to proceed to therapeutic abortion due to congenital abnormalities of the fetus (hydrocephalia), while she was on the first trimester of pregnancy. Conclusions We described male patients with AS and PsA who demonstrated no fertility problems while they were on infliximab treatment. The data designated in this report provide some supportive evidence for the safe use of infliximab in male patients who are affected of those inflammatory diseases during their peak reproductive years.</description><subject>Abortion</subject><subject>Adult</subject><subject>Ankylosing spondylitis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antibodies, Monoclonal - adverse effects</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Arthritis</subject><subject>Data processing</subject><subject>Development</subject><subject>Fertility</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Infants</subject><subject>Infertility, Male - chemically induced</subject><subject>Inflammatory diseases</subject><subject>Infliximab</subject><subject>Internal Medicine</subject><subject>Joint diseases</subject><subject>Male</subject><subject>Male fertility</subject><subject>Monoclonal antibodies</subject><subject>Pregnancy</subject><subject>Psoriatic arthritis</subject><subject>Rheumatology</subject><subject>Spermatogenesis - drug effects</subject><subject>Spine</subject><subject>Spondylarthropathies - drug therapy</subject><subject>Spondyloarthropathies</subject><subject>spondyloarthropathy</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><issn>1297-319X</issn><issn>1778-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2L1TAUhosozof-A5Eu3bTms002ggyOIwy4UEHchDQ59abmJjXJHb3_3lw6unAzq4TwvOecvO9pmhcY9Rjh4fXSL1NeXegJwqRHtEeIPWrO8TiKbiScPa53IseOYvn1rLnIeUEIUcKHp80ZIXzkaBjPm2_XkIrzrhxbF9q99tCuujgIJbe_XNm1GVIM8L2-3UGb1xjs0Uedyi7FCu4c5LYk0AXsxrswe_fb7fX0rHkya5_h-f152Xy5fvf56qa7_fj-w9Xb284wjkpHEbHC6olzO1AyDcRMdTg7CSnsjAY2CgGyTi4nNoKYqbUagQUmNRGc8ZleNq-2umuKPw-Qi9q7bMB7HSAessIU84FQKdnDKBFEUCmErCjbUJNizglmtab6q3RUGKlTAGpRWwDqFIBCVNUAquzlfYfDtAf7T_TX8Qq82QColtw5SCqbarcB6xKYomx0D3X4v4DxLjij_Q84Ql7iIYVqt8IqV436dFqC0w5gUvPnEtE_-bqvXQ</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Saougou, Ioanna</creator><creator>Markatseli, Theodora E</creator><creator>Papagoras, Charalampos</creator><creator>Kaltsonoudis, Evripidis</creator><creator>Voulgari, Paraskevi V</creator><creator>Drosos, Alexandros A</creator><general>Elsevier SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20130101</creationdate><title>Fertility in male patients with seronegative spondyloarthropathies treated with infliximab</title><author>Saougou, Ioanna ; Markatseli, Theodora E ; Papagoras, Charalampos ; Kaltsonoudis, Evripidis ; Voulgari, Paraskevi V ; Drosos, Alexandros A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-302d8dab55d632b62cb575db898df064788e90039b47e8f3dda0ede49a28545f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abortion</topic><topic>Adult</topic><topic>Ankylosing spondylitis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antibodies, Monoclonal - adverse effects</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Arthritis</topic><topic>Data processing</topic><topic>Development</topic><topic>Fertility</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Infants</topic><topic>Infertility, Male - chemically induced</topic><topic>Inflammatory diseases</topic><topic>Infliximab</topic><topic>Internal Medicine</topic><topic>Joint diseases</topic><topic>Male</topic><topic>Male fertility</topic><topic>Monoclonal antibodies</topic><topic>Pregnancy</topic><topic>Psoriatic arthritis</topic><topic>Rheumatology</topic><topic>Spermatogenesis - drug effects</topic><topic>Spine</topic><topic>Spondylarthropathies - drug therapy</topic><topic>Spondyloarthropathies</topic><topic>spondyloarthropathy</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saougou, Ioanna</creatorcontrib><creatorcontrib>Markatseli, Theodora E</creatorcontrib><creatorcontrib>Papagoras, Charalampos</creatorcontrib><creatorcontrib>Kaltsonoudis, Evripidis</creatorcontrib><creatorcontrib>Voulgari, Paraskevi V</creatorcontrib><creatorcontrib>Drosos, Alexandros A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saougou, Ioanna</au><au>Markatseli, Theodora E</au><au>Papagoras, Charalampos</au><au>Kaltsonoudis, Evripidis</au><au>Voulgari, Paraskevi V</au><au>Drosos, Alexandros A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility in male patients with seronegative spondyloarthropathies treated with infliximab</atitle><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle><addtitle>Joint Bone Spine</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>80</volume><issue>1</issue><spage>34</spage><epage>37</epage><pages>34-37</pages><issn>1297-319X</issn><eissn>1778-7254</eissn><abstract>Abstract Objectives The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment for these patients. To identify male patients who achieved pregnancy development during their management with anti-TNFα blockers (infliximab). Methods We reviewed the data of 65 patients with AS and 30 patients with PsA who were followed-up in our rheumatology outpatients clinic and they were on infliximab therapy between January 2001 and December 2010. Results We identified overall seven male patients with AS and three male patients with PsA who had fathered 14 healthy infants. Moreover, we recognized one man with PsA who was on infliximab and on concomitant therapy with MTX at the time of conception, whose wife had to proceed to therapeutic abortion due to congenital abnormalities of the fetus (hydrocephalia), while she was on the first trimester of pregnancy. Conclusions We described male patients with AS and PsA who demonstrated no fertility problems while they were on infliximab treatment. The data designated in this report provide some supportive evidence for the safe use of infliximab in male patients who are affected of those inflammatory diseases during their peak reproductive years.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>22575067</pmid><doi>10.1016/j.jbspin.2012.03.004</doi><tpages>4</tpages></addata></record> |
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| ispartof | Joint, bone, spine : revue du rhumatisme, 2013-01, Vol.80 (1), p.34-37 |
| issn | 1297-319X 1778-7254 |
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| subjects | Abortion Adult Ankylosing spondylitis Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arthritis Data processing Development Fertility Fetuses Humans Infants Infertility, Male - chemically induced Inflammatory diseases Infliximab Internal Medicine Joint diseases Male Male fertility Monoclonal antibodies Pregnancy Psoriatic arthritis Rheumatology Spermatogenesis - drug effects Spine Spondylarthropathies - drug therapy Spondyloarthropathies spondyloarthropathy Tumor necrosis factor Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Fertility in male patients with seronegative spondyloarthropathies treated with infliximab |
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