Differential expression of parvalbumin in neonatal phencyclidine‐treated rats and socially isolated rats

Decreased parvalbumin expression is a hallmark of the pathophysiology of schizophrenia and has been associated with abnormal cognitive processing and decreased network specificity. It is not known whether this decrease is due to reduced expression of the parvalbumin protein or degeneration of parval...

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Veröffentlicht in:	Journal of neurochemistry 2013-02, Vol.124 (4), p.548-557
Hauptverfasser:	Kaalund, Sanne S., Riise, Jesper, Broberg, Brian V., Fabricius, Katrine, Karlsen, Anna S., Secher, Thomas, Plath, Niels, Pakkenberg, Bente
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Autoradiography Brain - drug effects Brain - metabolism Brain - pathology Cell Count Cognition Disorders - etiology Cognition Disorders - pathology Disease Models, Animal Excitatory Amino Acid Antagonists - toxicity Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Male Motor Activity - drug effects neonatal PCP Neurochemistry Neuroglia - drug effects Neuroglia - metabolism Neurons Neurons - drug effects Neurons - metabolism parvalbumin Parvalbumins - genetics Parvalbumins - metabolism Phencyclidine - toxicity Phosphopyruvate Hydratase - metabolism Proteins Rats RNA, Messenger - metabolism Rodents Schizophrenia Schizophrenia - chemically induced Schizophrenia - pathology Social Isolation stereology
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