Transcranial brain sonography findings in two main variants of progressive supranuclear palsy
Background and purpose Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP‐RS) and as PSP‐parkinsonism (PSP‐P), the most common atypical PSP variant. The differential diagnosis between them is challenging. There...
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| Veröffentlicht in: | European journal of neurology 2013-03, Vol.20 (3), p.552-557 |
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| creator | Kostić, V. S. Mijajlović, M. Smajlović, D. Lukić, M. J. Tomić, A. Svetel, M. |
| description | Background and purpose
Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP‐RS) and as PSP‐parkinsonism (PSP‐P), the most common atypical PSP variant. The differential diagnosis between them is challenging. Therefore, we studied different ultrasound markers by transcranial sonography in individuals with PSP‐RS and PSP‐P, to test their value in the diagnostic work up of these patients.
Methods
Transcranial sonography was performed in 21 patients with PSP‐RS and 11 patients with PSP‐P. Echogenic sizes of the substantia nigra (SN) and the lenticular nuclei (LN), as well as the width of the third ventricle, were measured.
Results
Among the patients with PSP‐RS and PSP‐P, three (14%) and eight (73%) patients had a hyperechogenic SN (P = 0.020), respectively. Uni‐ or bilateral hyperechogenicity of the LN was observed in 67% and 36% of patients with PSP‐RS and PSP‐P, respectively (P = 0.101). Third ventricle was significantly wider in patients with PSP‐RS (11.2 ± 2.3 mm) when compared with patients with PSP‐P (7.5 ± 1.4 mm; P = 0.001).
Conclusion
Our data, possibly reflecting pathological differences, primarily contribute supporting the view that the neurodegenerative process differs in the two PSP variants. |
| doi_str_mv | 10.1111/ene.12034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315621232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1288313003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4244-45e47ddbd5672a5768db8f44acf3cc8df1d4ea7bc9e8b48cd92531b24b0f9303</originalsourceid><addsrcrecordid>eNqFkc9vFCEUx4nR9Jc9-A8YEi_2MC2PBwNzNM22app62diTIQzDVOosM8JO6_73sm7bg4mRA4_A533yyJeQN8BOoawzH_0pcIbiBTkAUesKEOFlOaOESgKDfXKY8x1jjCvO9sg-R1DYKH1Avi2TjdmVLdiBtsmGSPMYx9tkp-8b2ofYhXibableP4x0tX2_tynYuM507OmUCupzDvee5nkqntkN3iY62SFvXpNXfan--LEekeXFYnn-sbr6cvnp_MNV5QQXohLSC9V1bSdrxa1Ute5a3QthXY_O6a6HTnirWtd43QrtuoZLhJaLlvUNMjwi73faMs3P2ee1WYXs_DDY6Mc5G0CQNQeO_P8o1xoBGcOCvvsLvRvnFMs_tpRChSibQp3sKJfGnJPvzZTCyqaNAWa26ZiSjvmTTmHfPhrnduW7Z_IpjgKc7YCHMPjNv01mcb14Ula7jpDX_tdzh00_TF1GlObm-tLA568S5cWNUfgbtAyoZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1287373359</pqid></control><display><type>article</type><title>Transcranial brain sonography findings in two main variants of progressive supranuclear palsy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kostić, V. S. ; Mijajlović, M. ; Smajlović, D. ; Lukić, M. J. ; Tomić, A. ; Svetel, M.</creator><creatorcontrib>Kostić, V. S. ; Mijajlović, M. ; Smajlović, D. ; Lukić, M. J. ; Tomić, A. ; Svetel, M.</creatorcontrib><description>Background and purpose
Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP‐RS) and as PSP‐parkinsonism (PSP‐P), the most common atypical PSP variant. The differential diagnosis between them is challenging. Therefore, we studied different ultrasound markers by transcranial sonography in individuals with PSP‐RS and PSP‐P, to test their value in the diagnostic work up of these patients.
Methods
Transcranial sonography was performed in 21 patients with PSP‐RS and 11 patients with PSP‐P. Echogenic sizes of the substantia nigra (SN) and the lenticular nuclei (LN), as well as the width of the third ventricle, were measured.
Results
Among the patients with PSP‐RS and PSP‐P, three (14%) and eight (73%) patients had a hyperechogenic SN (P = 0.020), respectively. Uni‐ or bilateral hyperechogenicity of the LN was observed in 67% and 36% of patients with PSP‐RS and PSP‐P, respectively (P = 0.101). Third ventricle was significantly wider in patients with PSP‐RS (11.2 ± 2.3 mm) when compared with patients with PSP‐P (7.5 ± 1.4 mm; P = 0.001).
Conclusion
Our data, possibly reflecting pathological differences, primarily contribute supporting the view that the neurodegenerative process differs in the two PSP variants.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.12034</identifier><identifier>PMID: 23173978</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Brain ; Brain - pathology ; Data processing ; Differential diagnosis ; Female ; Humans ; Male ; Middle Aged ; progressive supranuclear palsy ; Substantia nigra ; Supranuclear Palsy, Progressive - diagnostic imaging ; transcranial sonography ; Ultrasonography, Doppler, Transcranial ; Ultrasound ; Ventricles (cerebral)</subject><ispartof>European journal of neurology, 2013-03, Vol.20 (3), p.552-557</ispartof><rights>2012 The Author(s) European Journal of Neurology © 2012 EFNS</rights><rights>2012 The Author(s) European Journal of Neurology © 2012 EFNS.</rights><rights>European Journal of Neurology © 2013 European Federation of Neurological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-45e47ddbd5672a5768db8f44acf3cc8df1d4ea7bc9e8b48cd92531b24b0f9303</citedby><cites>FETCH-LOGICAL-c4244-45e47ddbd5672a5768db8f44acf3cc8df1d4ea7bc9e8b48cd92531b24b0f9303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.12034$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.12034$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23173978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kostić, V. S.</creatorcontrib><creatorcontrib>Mijajlović, M.</creatorcontrib><creatorcontrib>Smajlović, D.</creatorcontrib><creatorcontrib>Lukić, M. J.</creatorcontrib><creatorcontrib>Tomić, A.</creatorcontrib><creatorcontrib>Svetel, M.</creatorcontrib><title>Transcranial brain sonography findings in two main variants of progressive supranuclear palsy</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP‐RS) and as PSP‐parkinsonism (PSP‐P), the most common atypical PSP variant. The differential diagnosis between them is challenging. Therefore, we studied different ultrasound markers by transcranial sonography in individuals with PSP‐RS and PSP‐P, to test their value in the diagnostic work up of these patients.
Methods
Transcranial sonography was performed in 21 patients with PSP‐RS and 11 patients with PSP‐P. Echogenic sizes of the substantia nigra (SN) and the lenticular nuclei (LN), as well as the width of the third ventricle, were measured.
Results
Among the patients with PSP‐RS and PSP‐P, three (14%) and eight (73%) patients had a hyperechogenic SN (P = 0.020), respectively. Uni‐ or bilateral hyperechogenicity of the LN was observed in 67% and 36% of patients with PSP‐RS and PSP‐P, respectively (P = 0.101). Third ventricle was significantly wider in patients with PSP‐RS (11.2 ± 2.3 mm) when compared with patients with PSP‐P (7.5 ± 1.4 mm; P = 0.001).
Conclusion
Our data, possibly reflecting pathological differences, primarily contribute supporting the view that the neurodegenerative process differs in the two PSP variants.</description><subject>Aged</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Data processing</subject><subject>Differential diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>progressive supranuclear palsy</subject><subject>Substantia nigra</subject><subject>Supranuclear Palsy, Progressive - diagnostic imaging</subject><subject>transcranial sonography</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Ultrasound</subject><subject>Ventricles (cerebral)</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9vFCEUx4nR9Jc9-A8YEi_2MC2PBwNzNM22app62diTIQzDVOosM8JO6_73sm7bg4mRA4_A533yyJeQN8BOoawzH_0pcIbiBTkAUesKEOFlOaOESgKDfXKY8x1jjCvO9sg-R1DYKH1Avi2TjdmVLdiBtsmGSPMYx9tkp-8b2ofYhXibableP4x0tX2_tynYuM507OmUCupzDvee5nkqntkN3iY62SFvXpNXfan--LEekeXFYnn-sbr6cvnp_MNV5QQXohLSC9V1bSdrxa1Ute5a3QthXY_O6a6HTnirWtd43QrtuoZLhJaLlvUNMjwi73faMs3P2ee1WYXs_DDY6Mc5G0CQNQeO_P8o1xoBGcOCvvsLvRvnFMs_tpRChSibQp3sKJfGnJPvzZTCyqaNAWa26ZiSjvmTTmHfPhrnduW7Z_IpjgKc7YCHMPjNv01mcb14Ula7jpDX_tdzh00_TF1GlObm-tLA568S5cWNUfgbtAyoZg</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Kostić, V. S.</creator><creator>Mijajlović, M.</creator><creator>Smajlović, D.</creator><creator>Lukić, M. J.</creator><creator>Tomić, A.</creator><creator>Svetel, M.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Transcranial brain sonography findings in two main variants of progressive supranuclear palsy</title><author>Kostić, V. S. ; Mijajlović, M. ; Smajlović, D. ; Lukić, M. J. ; Tomić, A. ; Svetel, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4244-45e47ddbd5672a5768db8f44acf3cc8df1d4ea7bc9e8b48cd92531b24b0f9303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Data processing</topic><topic>Differential diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>progressive supranuclear palsy</topic><topic>Substantia nigra</topic><topic>Supranuclear Palsy, Progressive - diagnostic imaging</topic><topic>transcranial sonography</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Ultrasound</topic><topic>Ventricles (cerebral)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kostić, V. S.</creatorcontrib><creatorcontrib>Mijajlović, M.</creatorcontrib><creatorcontrib>Smajlović, D.</creatorcontrib><creatorcontrib>Lukić, M. J.</creatorcontrib><creatorcontrib>Tomić, A.</creatorcontrib><creatorcontrib>Svetel, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kostić, V. S.</au><au>Mijajlović, M.</au><au>Smajlović, D.</au><au>Lukić, M. J.</au><au>Tomić, A.</au><au>Svetel, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial brain sonography findings in two main variants of progressive supranuclear palsy</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2013-03</date><risdate>2013</risdate><volume>20</volume><issue>3</issue><spage>552</spage><epage>557</epage><pages>552-557</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose
Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP‐RS) and as PSP‐parkinsonism (PSP‐P), the most common atypical PSP variant. The differential diagnosis between them is challenging. Therefore, we studied different ultrasound markers by transcranial sonography in individuals with PSP‐RS and PSP‐P, to test their value in the diagnostic work up of these patients.
Methods
Transcranial sonography was performed in 21 patients with PSP‐RS and 11 patients with PSP‐P. Echogenic sizes of the substantia nigra (SN) and the lenticular nuclei (LN), as well as the width of the third ventricle, were measured.
Results
Among the patients with PSP‐RS and PSP‐P, three (14%) and eight (73%) patients had a hyperechogenic SN (P = 0.020), respectively. Uni‐ or bilateral hyperechogenicity of the LN was observed in 67% and 36% of patients with PSP‐RS and PSP‐P, respectively (P = 0.101). Third ventricle was significantly wider in patients with PSP‐RS (11.2 ± 2.3 mm) when compared with patients with PSP‐P (7.5 ± 1.4 mm; P = 0.001).
Conclusion
Our data, possibly reflecting pathological differences, primarily contribute supporting the view that the neurodegenerative process differs in the two PSP variants.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23173978</pmid><doi>10.1111/ene.12034</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Brain Brain - pathology Data processing Differential diagnosis Female Humans Male Middle Aged progressive supranuclear palsy Substantia nigra Supranuclear Palsy, Progressive - diagnostic imaging transcranial sonography Ultrasonography, Doppler, Transcranial Ultrasound Ventricles (cerebral) |
| title | Transcranial brain sonography findings in two main variants of progressive supranuclear palsy |
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