Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
TCR alpha beta thymocytes differentiate into either CD8 alpha beta super(+) cytotoxic T lymphocytes or CD4 super(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in majo...
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2013-03, Vol.14 (3), p.281-289 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 289 |
|---|---|
| container_issue | 3 |
| container_start_page | 281 |
| container_title | Nature immunology |
| container_volume | 14 |
| creator | Mucida, Daniel Husain, Mohammad Mushtaq Muroi, Sawako van Wijk, Femke Shinnakasu, Ryo Naoe, Yoshinori Reis, Bernardo Sgarbi Huang, Yujun Lambolez, Florence Docherty, Michael Attinger, Antoine Shui, Jr-Wen Kim, Gisen Lena, Christopher J Sakaguchi, Shinya Miyamoto, Chizuko Wang, Peng Atarashi, Koji Park, Yunji Nakayama, Toshinori Honda, Kenya Ellmeier, Wilfried Kronenberg, Mitchell Taniuchi, Ichiro Cheroutre, Hilde |
| description | TCR alpha beta thymocytes differentiate into either CD8 alpha beta super(+) cytotoxic T lymphocytes or CD4 super(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4 super(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4 super(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4 super(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4 super(+) cytotoxic T lymphocytes. |
| doi_str_mv | 10.1038/ni.2523 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315620713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1315620713</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_13156207133</originalsourceid><addsrcrecordid>eNqVjstOwzAURL0AifIQv3CXRSjFdpI-1gHULrrLvrLc29TIj3CvI9Ef4LsxEj_AakajOZoR4lHJhZL1-iW6hW51fSVmqtWbSm_k-kbcMn9IqZrVspmJ755MZEtuzC5F44FwpDSQCcHFAdIJgskTIXSvDfA0Is2fn-CMvjjowaL3DANGJJOR4eg4u2gz7LcdWG-YYberCDmTsxmPYC855fTlbIH9JYznVBLke3F9Mp7x4U_vxPz9re-2VTnzORX8EBz_jpmIaeKDqlW71HKl6vof1R-gjVmf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1315620713</pqid></control><display><type>article</type><title>Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes</title><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Mucida, Daniel ; Husain, Mohammad Mushtaq ; Muroi, Sawako ; van Wijk, Femke ; Shinnakasu, Ryo ; Naoe, Yoshinori ; Reis, Bernardo Sgarbi ; Huang, Yujun ; Lambolez, Florence ; Docherty, Michael ; Attinger, Antoine ; Shui, Jr-Wen ; Kim, Gisen ; Lena, Christopher J ; Sakaguchi, Shinya ; Miyamoto, Chizuko ; Wang, Peng ; Atarashi, Koji ; Park, Yunji ; Nakayama, Toshinori ; Honda, Kenya ; Ellmeier, Wilfried ; Kronenberg, Mitchell ; Taniuchi, Ichiro ; Cheroutre, Hilde</creator><creatorcontrib>Mucida, Daniel ; Husain, Mohammad Mushtaq ; Muroi, Sawako ; van Wijk, Femke ; Shinnakasu, Ryo ; Naoe, Yoshinori ; Reis, Bernardo Sgarbi ; Huang, Yujun ; Lambolez, Florence ; Docherty, Michael ; Attinger, Antoine ; Shui, Jr-Wen ; Kim, Gisen ; Lena, Christopher J ; Sakaguchi, Shinya ; Miyamoto, Chizuko ; Wang, Peng ; Atarashi, Koji ; Park, Yunji ; Nakayama, Toshinori ; Honda, Kenya ; Ellmeier, Wilfried ; Kronenberg, Mitchell ; Taniuchi, Ichiro ; Cheroutre, Hilde</creatorcontrib><description>TCR alpha beta thymocytes differentiate into either CD8 alpha beta super(+) cytotoxic T lymphocytes or CD4 super(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4 super(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4 super(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4 super(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4 super(+) cytotoxic T lymphocytes.</description><identifier>ISSN: 1529-2908</identifier><identifier>DOI: 10.1038/ni.2523</identifier><language>eng</language><ispartof>Nature immunology, 2013-03, Vol.14 (3), p.281-289</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids></links><search><creatorcontrib>Mucida, Daniel</creatorcontrib><creatorcontrib>Husain, Mohammad Mushtaq</creatorcontrib><creatorcontrib>Muroi, Sawako</creatorcontrib><creatorcontrib>van Wijk, Femke</creatorcontrib><creatorcontrib>Shinnakasu, Ryo</creatorcontrib><creatorcontrib>Naoe, Yoshinori</creatorcontrib><creatorcontrib>Reis, Bernardo Sgarbi</creatorcontrib><creatorcontrib>Huang, Yujun</creatorcontrib><creatorcontrib>Lambolez, Florence</creatorcontrib><creatorcontrib>Docherty, Michael</creatorcontrib><creatorcontrib>Attinger, Antoine</creatorcontrib><creatorcontrib>Shui, Jr-Wen</creatorcontrib><creatorcontrib>Kim, Gisen</creatorcontrib><creatorcontrib>Lena, Christopher J</creatorcontrib><creatorcontrib>Sakaguchi, Shinya</creatorcontrib><creatorcontrib>Miyamoto, Chizuko</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Atarashi, Koji</creatorcontrib><creatorcontrib>Park, Yunji</creatorcontrib><creatorcontrib>Nakayama, Toshinori</creatorcontrib><creatorcontrib>Honda, Kenya</creatorcontrib><creatorcontrib>Ellmeier, Wilfried</creatorcontrib><creatorcontrib>Kronenberg, Mitchell</creatorcontrib><creatorcontrib>Taniuchi, Ichiro</creatorcontrib><creatorcontrib>Cheroutre, Hilde</creatorcontrib><title>Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes</title><title>Nature immunology</title><description>TCR alpha beta thymocytes differentiate into either CD8 alpha beta super(+) cytotoxic T lymphocytes or CD4 super(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4 super(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4 super(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4 super(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4 super(+) cytotoxic T lymphocytes.</description><issn>1529-2908</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVjstOwzAURL0AifIQv3CXRSjFdpI-1gHULrrLvrLc29TIj3CvI9Ef4LsxEj_AakajOZoR4lHJhZL1-iW6hW51fSVmqtWbSm_k-kbcMn9IqZrVspmJ755MZEtuzC5F44FwpDSQCcHFAdIJgskTIXSvDfA0Is2fn-CMvjjowaL3DANGJJOR4eg4u2gz7LcdWG-YYberCDmTsxmPYC855fTlbIH9JYznVBLke3F9Mp7x4U_vxPz9re-2VTnzORX8EBz_jpmIaeKDqlW71HKl6vof1R-gjVmf</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Mucida, Daniel</creator><creator>Husain, Mohammad Mushtaq</creator><creator>Muroi, Sawako</creator><creator>van Wijk, Femke</creator><creator>Shinnakasu, Ryo</creator><creator>Naoe, Yoshinori</creator><creator>Reis, Bernardo Sgarbi</creator><creator>Huang, Yujun</creator><creator>Lambolez, Florence</creator><creator>Docherty, Michael</creator><creator>Attinger, Antoine</creator><creator>Shui, Jr-Wen</creator><creator>Kim, Gisen</creator><creator>Lena, Christopher J</creator><creator>Sakaguchi, Shinya</creator><creator>Miyamoto, Chizuko</creator><creator>Wang, Peng</creator><creator>Atarashi, Koji</creator><creator>Park, Yunji</creator><creator>Nakayama, Toshinori</creator><creator>Honda, Kenya</creator><creator>Ellmeier, Wilfried</creator><creator>Kronenberg, Mitchell</creator><creator>Taniuchi, Ichiro</creator><creator>Cheroutre, Hilde</creator><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130301</creationdate><title>Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes</title><author>Mucida, Daniel ; Husain, Mohammad Mushtaq ; Muroi, Sawako ; van Wijk, Femke ; Shinnakasu, Ryo ; Naoe, Yoshinori ; Reis, Bernardo Sgarbi ; Huang, Yujun ; Lambolez, Florence ; Docherty, Michael ; Attinger, Antoine ; Shui, Jr-Wen ; Kim, Gisen ; Lena, Christopher J ; Sakaguchi, Shinya ; Miyamoto, Chizuko ; Wang, Peng ; Atarashi, Koji ; Park, Yunji ; Nakayama, Toshinori ; Honda, Kenya ; Ellmeier, Wilfried ; Kronenberg, Mitchell ; Taniuchi, Ichiro ; Cheroutre, Hilde</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_13156207133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mucida, Daniel</creatorcontrib><creatorcontrib>Husain, Mohammad Mushtaq</creatorcontrib><creatorcontrib>Muroi, Sawako</creatorcontrib><creatorcontrib>van Wijk, Femke</creatorcontrib><creatorcontrib>Shinnakasu, Ryo</creatorcontrib><creatorcontrib>Naoe, Yoshinori</creatorcontrib><creatorcontrib>Reis, Bernardo Sgarbi</creatorcontrib><creatorcontrib>Huang, Yujun</creatorcontrib><creatorcontrib>Lambolez, Florence</creatorcontrib><creatorcontrib>Docherty, Michael</creatorcontrib><creatorcontrib>Attinger, Antoine</creatorcontrib><creatorcontrib>Shui, Jr-Wen</creatorcontrib><creatorcontrib>Kim, Gisen</creatorcontrib><creatorcontrib>Lena, Christopher J</creatorcontrib><creatorcontrib>Sakaguchi, Shinya</creatorcontrib><creatorcontrib>Miyamoto, Chizuko</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Atarashi, Koji</creatorcontrib><creatorcontrib>Park, Yunji</creatorcontrib><creatorcontrib>Nakayama, Toshinori</creatorcontrib><creatorcontrib>Honda, Kenya</creatorcontrib><creatorcontrib>Ellmeier, Wilfried</creatorcontrib><creatorcontrib>Kronenberg, Mitchell</creatorcontrib><creatorcontrib>Taniuchi, Ichiro</creatorcontrib><creatorcontrib>Cheroutre, Hilde</creatorcontrib><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mucida, Daniel</au><au>Husain, Mohammad Mushtaq</au><au>Muroi, Sawako</au><au>van Wijk, Femke</au><au>Shinnakasu, Ryo</au><au>Naoe, Yoshinori</au><au>Reis, Bernardo Sgarbi</au><au>Huang, Yujun</au><au>Lambolez, Florence</au><au>Docherty, Michael</au><au>Attinger, Antoine</au><au>Shui, Jr-Wen</au><au>Kim, Gisen</au><au>Lena, Christopher J</au><au>Sakaguchi, Shinya</au><au>Miyamoto, Chizuko</au><au>Wang, Peng</au><au>Atarashi, Koji</au><au>Park, Yunji</au><au>Nakayama, Toshinori</au><au>Honda, Kenya</au><au>Ellmeier, Wilfried</au><au>Kronenberg, Mitchell</au><au>Taniuchi, Ichiro</au><au>Cheroutre, Hilde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes</atitle><jtitle>Nature immunology</jtitle><date>2013-03-01</date><risdate>2013</risdate><volume>14</volume><issue>3</issue><spage>281</spage><epage>289</epage><pages>281-289</pages><issn>1529-2908</issn><abstract>TCR alpha beta thymocytes differentiate into either CD8 alpha beta super(+) cytotoxic T lymphocytes or CD4 super(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4 super(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4 super(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4 super(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4 super(+) cytotoxic T lymphocytes.</abstract><doi>10.1038/ni.2523</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2013-03, Vol.14 (3), p.281-289 |
| issn | 1529-2908 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1315620713 |
| source | Nature; Alma/SFX Local Collection |
| title | Transcriptional reprogramming of mature CD4 super(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T23%3A54%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transcriptional%20reprogramming%20of%20mature%20CD4%20super(+)%20helper%20T%20cells%20generates%20distinct%20MHC%20class%20II-restricted%20cytotoxic%20T%20lymphocytes&rft.jtitle=Nature%20immunology&rft.au=Mucida,%20Daniel&rft.date=2013-03-01&rft.volume=14&rft.issue=3&rft.spage=281&rft.epage=289&rft.pages=281-289&rft.issn=1529-2908&rft_id=info:doi/10.1038/ni.2523&rft_dat=%3Cproquest%3E1315620713%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1315620713&rft_id=info:pmid/&rfr_iscdi=true |