Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells

Loss of the cell adhesion protein E-cadherin increases the invasive capability of ovarian cancer cells. We have previously shown that epidermal growth factor (EGF) downregulates E-cadherin and induces ovarian cancer cell invasion through the H 2 O 2 /p38 MAPK-mediated upregulation of the E-cadherin...

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Veröffentlicht in:	Oncogene 2013-02, Vol.32 (8), p.1041-1049
Hauptverfasser:	Cheng, J-C, Chang, H-M, Leung, P C K
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/67/1517/1709 631/80/86 AKT protein Analysis Apoptosis Cadherins - biosynthesis Cadherins - genetics Cadherins - metabolism Cell adhesion Cell adhesion & migration Cell Biology Cell Line, Tumor Chromatin Down-Regulation - drug effects E-Cadherin Early Growth Response Protein 1 - biosynthesis Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism EGR-1 protein Epidermal growth factor Epidermal Growth Factor - pharmacology Extracellular signal-regulated kinase Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Glycoproteins Human Genetics Humans Hydrogen peroxide Immunoprecipitation Internal Medicine Invasiveness MAP kinase Medicine Medicine & Public Health Molecular modelling Oncology original-article Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Physiological aspects Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Repressors RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Signal transduction siRNA Snail Family Transcription Factors Snail protein Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor cell lines Zinc finger proteins
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