p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation

Inhibition of homologous recombination (HR) is believed to be a transactivation-independent function of p53 that protects from genetic instability. Misrepair by HR can lead to genetic alterations such as translocations, duplications, insertions and loss of heterozygosity, which all bear the risk of...

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Veröffentlicht in:	Oncogene 2013-02, Vol.32 (8), p.968-975
Hauptverfasser:	Rieckmann, T, Kriegs, M, Nitsch, L, Hoffer, K, Rohaly, G, Kocher, S, Petersen, C, Dikomey, E, Dornreiter, I, Dahm-Daphi, J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427/2190 631/80/641 692/420/755 Analysis Animals Apoptosis Carcinogenesis Cell Biology Cell cycle Cell Cycle Checkpoints - genetics Cell Line Cell Line, Tumor Cercopithecus aethiops Deoxyribonucleases, Type II Site-Specific - genetics DNA Breaks, Double-Stranded DNA damage G2 Phase - genetics Gene expression Genetic aspects Genetic transformation Genomic instability Heterozygosity Homologous Recombination Human Genetics Humans Internal Medicine Loss of heterozygosity Medicine Medicine & Public Health Mutants Mutation Oncology original-article p53 Protein Proteins S Phase - genetics Transfection Translocation Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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