Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids
N -methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2010-05, Vol.36 (3), p.383-389 |
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| container_end_page | 389 |
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| container_issue | 3 |
| container_start_page | 383 |
| container_title | Russian journal of bioorganic chemistry |
| container_volume | 36 |
| creator | Kazakova, O. B. Giniyatullina, G. V. Tolstikov, G. A. Medvedeva, N. I. Utkina, T. M. Kartashova, O. L. |
| description | N
-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against
Staphylococcus aureus
at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against
Klebsiella pneumoniae
at a concentration of 60 mg/ml. Among the studied
N
-methylpyperazinyl amides, the highest activity against
S. aureus
was observed for a betulonic acid derivative. |
| doi_str_mv | 10.1134/S1068162010030155 |
| format | Article |
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-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against
Staphylococcus aureus
at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against
Klebsiella pneumoniae
at a concentration of 60 mg/ml. Among the studied
N
-methylpyperazinyl amides, the highest activity against
S. aureus
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-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against
Staphylococcus aureus
at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against
Klebsiella pneumoniae
at a concentration of 60 mg/ml. Among the studied
N
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S. aureus
was observed for a betulonic acid derivative.</description><subject>Acids</subject><subject>amides</subject><subject>Antimicrobial activity</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Klebsiella pneumoniae</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><subject>Staphylococcus aureus</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouH78AG89erCaadqme5TFL1j0oIK3kqQTd5Z-mWSF-uvNut4ED8MMzPMMvMPYGfBLAJFfPQMvKygzDpwLDkWxx2ZQ8ioVgr_txzmu0-3-kB15v-ZbrqhmbP089WGFnvxF0g0NWTIq0NBfJKpvYgXqyLhBk2oTZQJ9UpiSwSbRSR7TDsNqakca0akv6qfIdNSg_yEcBXQj9mSiSY0_YQdWtR5Pf_sxe729eVncp8unu4fF9TI1IoOQWqlzLnIreWZwnkmRZ6gqKaRWUvC5NCiLeak1r1SuscnBxJh5pY3VQlRgxTE7390d3fCxQR_qjrzBtlU9Dhtfg4CihLIURURhh8aI3ju09eioU26qgdfbv9Z__hqdbOf4yPbv6Or1sHF9TPSP9A0XKXsi</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Kazakova, O. B.</creator><creator>Giniyatullina, G. V.</creator><creator>Tolstikov, G. A.</creator><creator>Medvedeva, N. I.</creator><creator>Utkina, T. M.</creator><creator>Kartashova, O. L.</creator><general>SP MAIK Nauka/Interperiodica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20100501</creationdate><title>Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids</title><author>Kazakova, O. B. ; Giniyatullina, G. V. ; Tolstikov, G. A. ; Medvedeva, N. I. ; Utkina, T. M. ; Kartashova, O. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-f7b4034f702ce927342ea8737ba73097ce7596bb08a4bed41c60848bcfb3381f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acids</topic><topic>amides</topic><topic>Antimicrobial activity</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Klebsiella pneumoniae</topic><topic>Life Sciences</topic><topic>Organic Chemistry</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazakova, O. B.</creatorcontrib><creatorcontrib>Giniyatullina, G. V.</creatorcontrib><creatorcontrib>Tolstikov, G. A.</creatorcontrib><creatorcontrib>Medvedeva, N. I.</creatorcontrib><creatorcontrib>Utkina, T. M.</creatorcontrib><creatorcontrib>Kartashova, O. L.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Russian journal of bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazakova, O. B.</au><au>Giniyatullina, G. V.</au><au>Tolstikov, G. A.</au><au>Medvedeva, N. I.</au><au>Utkina, T. M.</au><au>Kartashova, O. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids</atitle><jtitle>Russian journal of bioorganic chemistry</jtitle><stitle>Russ J Bioorg Chem</stitle><date>2010-05-01</date><risdate>2010</risdate><volume>36</volume><issue>3</issue><spage>383</spage><epage>389</epage><pages>383-389</pages><issn>1068-1620</issn><eissn>1608-330X</eissn><abstract>N
-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against
Staphylococcus aureus
at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against
Klebsiella pneumoniae
at a concentration of 60 mg/ml. Among the studied
N
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S. aureus
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| fulltext | fulltext |
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| ispartof | Russian journal of bioorganic chemistry, 2010-05, Vol.36 (3), p.383-389 |
| issn | 1068-1620 1608-330X |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acids amides Antimicrobial activity Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Klebsiella pneumoniae Life Sciences Organic Chemistry Staphylococcus aureus |
| title | Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids |
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