Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study
Objectives To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community. Design Prospective community‐based cohort study. Setting The population‐based Personnes Agée...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2013-01, Vol.61 (1), p.74-78 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Roubaud Baudron, Claire Letenneur, Luc Langlais, Anthony Buissonnière, Alice Mégraud, Francis Dartigues, Jean-François Salles, Nathalie |
| description | Objectives
To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community.
Design
Prospective community‐based cohort study.
Setting
The population‐based Personnes Agées QUID (PAQUID) Study.
Participants
Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.
Measurements
A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.
Results
At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow‐up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini‐Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04).
Conclusion
This longitudinal population‐based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration. |
| doi_str_mv | 10.1111/jgs.12065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315614587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1285463259</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4875-ee8d2c606a89e7a6cc984b9087365f884db3cc08c8190c0f5ce39ed32681c31c3</originalsourceid><addsrcrecordid>eNqN0d1qFDEUB_Agit1WL3wBGRBBL6bNx-RjrqR063al1Na2eBkymTN11tnJmsyg-0g-hy_mqbutIIiGQM7FLyfk_Al5xug-w3WwuEn7jFMlH5AJk4LnsmDyIZlQSnluFCt2yG5KC0oRGfOY7HDBJZdUT0g1DZCyE-haHyrnB4jZat2F2GbzvgE_tKHHykdwCW6LtobeQxaabApL6IfWvcmuPkF2DjGFvsdehzc_vuNxcT2fZpfDWK-fkEeN6xI83Z575Prt8dXRSX76fjY_OjzNfWG0zAFMzb2iypkStFPel6aoSmq0ULIxpqgr4T013rCSetpID6KEWnBlmBe498irTd9VDF9GSINdtslD17kewpgsE0ziLCQ2_C9KTWHUvyk3slA4zxLpiz_oIoyxxz-jUkbzAn-C6vVG-RhSitDYVWyXLq4to_Y2Totx2l9xon2-7ThWS6jv5V1-CF5ugUvedU10GFH67TQaxhm6g4372naw_vuL9t3s8u7pfHOjTQN8u7_h4mertNDSfjyb2fOLMy2k-mCV-AkznsLL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1268724365</pqid></control><display><type>article</type><title>Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Roubaud Baudron, Claire ; Letenneur, Luc ; Langlais, Anthony ; Buissonnière, Alice ; Mégraud, Francis ; Dartigues, Jean-François ; Salles, Nathalie</creator><creatorcontrib>Roubaud Baudron, Claire ; Letenneur, Luc ; Langlais, Anthony ; Buissonnière, Alice ; Mégraud, Francis ; Dartigues, Jean-François ; Salles, Nathalie ; Personnes Agées QUID Study ; for the Personnes Agées QUID Study</creatorcontrib><description>Objectives
To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community.
Design
Prospective community‐based cohort study.
Setting
The population‐based Personnes Agées QUID (PAQUID) Study.
Participants
Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.
Measurements
A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.
Results
At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow‐up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini‐Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04).
Conclusion
This longitudinal population‐based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.12065</identifier><identifier>PMID: 23252507</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Alzheimer's disease ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacterial infections ; Biological and medical sciences ; Dementia ; Dementia - epidemiology ; Dementia - etiology ; Disease Progression ; Educational Status ; elderly ; Female ; Follow-Up Studies ; France - epidemiology ; General aspects ; Helicobacter Infections - complications ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Helicobacter pylori infection ; Human bacterial diseases ; Humans ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Miscellaneous ; Older people ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Sex Distribution ; Stomach ; Time Factors</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2013-01, Vol.61 (1), p.74-78</ispartof><rights>2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society</rights><rights>2014 INIST-CNRS</rights><rights>2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.</rights><rights>2013 American Geriatrics Society and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4875-ee8d2c606a89e7a6cc984b9087365f884db3cc08c8190c0f5ce39ed32681c31c3</citedby><cites>FETCH-LOGICAL-c4875-ee8d2c606a89e7a6cc984b9087365f884db3cc08c8190c0f5ce39ed32681c31c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgs.12065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgs.12065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,4022,27922,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27073121$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23252507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roubaud Baudron, Claire</creatorcontrib><creatorcontrib>Letenneur, Luc</creatorcontrib><creatorcontrib>Langlais, Anthony</creatorcontrib><creatorcontrib>Buissonnière, Alice</creatorcontrib><creatorcontrib>Mégraud, Francis</creatorcontrib><creatorcontrib>Dartigues, Jean-François</creatorcontrib><creatorcontrib>Salles, Nathalie</creatorcontrib><creatorcontrib>Personnes Agées QUID Study</creatorcontrib><creatorcontrib>for the Personnes Agées QUID Study</creatorcontrib><title>Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives
To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community.
Design
Prospective community‐based cohort study.
Setting
The population‐based Personnes Agées QUID (PAQUID) Study.
Participants
Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.
Measurements
A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.
Results
At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow‐up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini‐Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04).
Conclusion
This longitudinal population‐based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bacterial infections</subject><subject>Biological and medical sciences</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia - etiology</subject><subject>Disease Progression</subject><subject>Educational Status</subject><subject>elderly</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>France - epidemiology</subject><subject>General aspects</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori infection</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Older people</subject><subject>Prevalence</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Stomach</subject><subject>Time Factors</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0d1qFDEUB_Agit1WL3wBGRBBL6bNx-RjrqR063al1Na2eBkymTN11tnJmsyg-0g-hy_mqbutIIiGQM7FLyfk_Al5xug-w3WwuEn7jFMlH5AJk4LnsmDyIZlQSnluFCt2yG5KC0oRGfOY7HDBJZdUT0g1DZCyE-haHyrnB4jZat2F2GbzvgE_tKHHykdwCW6LtobeQxaabApL6IfWvcmuPkF2DjGFvsdehzc_vuNxcT2fZpfDWK-fkEeN6xI83Z575Prt8dXRSX76fjY_OjzNfWG0zAFMzb2iypkStFPel6aoSmq0ULIxpqgr4T013rCSetpID6KEWnBlmBe498irTd9VDF9GSINdtslD17kewpgsE0ziLCQ2_C9KTWHUvyk3slA4zxLpiz_oIoyxxz-jUkbzAn-C6vVG-RhSitDYVWyXLq4to_Y2Totx2l9xon2-7ThWS6jv5V1-CF5ugUvedU10GFH67TQaxhm6g4372naw_vuL9t3s8u7pfHOjTQN8u7_h4mertNDSfjyb2fOLMy2k-mCV-AkznsLL</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Roubaud Baudron, Claire</creator><creator>Letenneur, Luc</creator><creator>Langlais, Anthony</creator><creator>Buissonnière, Alice</creator><creator>Mégraud, Francis</creator><creator>Dartigues, Jean-François</creator><creator>Salles, Nathalie</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>201301</creationdate><title>Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study</title><author>Roubaud Baudron, Claire ; Letenneur, Luc ; Langlais, Anthony ; Buissonnière, Alice ; Mégraud, Francis ; Dartigues, Jean-François ; Salles, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4875-ee8d2c606a89e7a6cc984b9087365f884db3cc08c8190c0f5ce39ed32681c31c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Bacterial infections</topic><topic>Biological and medical sciences</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia - etiology</topic><topic>Disease Progression</topic><topic>Educational Status</topic><topic>elderly</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>France - epidemiology</topic><topic>General aspects</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori infection</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Older people</topic><topic>Prevalence</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Stomach</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roubaud Baudron, Claire</creatorcontrib><creatorcontrib>Letenneur, Luc</creatorcontrib><creatorcontrib>Langlais, Anthony</creatorcontrib><creatorcontrib>Buissonnière, Alice</creatorcontrib><creatorcontrib>Mégraud, Francis</creatorcontrib><creatorcontrib>Dartigues, Jean-François</creatorcontrib><creatorcontrib>Salles, Nathalie</creatorcontrib><creatorcontrib>Personnes Agées QUID Study</creatorcontrib><creatorcontrib>for the Personnes Agées QUID Study</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roubaud Baudron, Claire</au><au>Letenneur, Luc</au><au>Langlais, Anthony</au><au>Buissonnière, Alice</au><au>Mégraud, Francis</au><au>Dartigues, Jean-François</au><au>Salles, Nathalie</au><aucorp>Personnes Agées QUID Study</aucorp><aucorp>for the Personnes Agées QUID Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2013-01</date><risdate>2013</risdate><volume>61</volume><issue>1</issue><spage>74</spage><epage>78</epage><pages>74-78</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives
To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community.
Design
Prospective community‐based cohort study.
Setting
The population‐based Personnes Agées QUID (PAQUID) Study.
Participants
Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.
Measurements
A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.
Results
At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow‐up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini‐Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04).
Conclusion
This longitudinal population‐based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23252507</pmid><doi>10.1111/jgs.12065</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0002-8614 |
| ispartof | Journal of the American Geriatrics Society (JAGS), 2013-01, Vol.61 (1), p.74-78 |
| issn | 0002-8614 1532-5415 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Age Factors Aged Alzheimer's disease Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial infections Biological and medical sciences Dementia Dementia - epidemiology Dementia - etiology Disease Progression Educational Status elderly Female Follow-Up Studies France - epidemiology General aspects Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter pylori Helicobacter pylori infection Human bacterial diseases Humans Incidence Infectious diseases Male Medical sciences Miscellaneous Older people Prevalence Proportional Hazards Models Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Sex Distribution Stomach Time Factors |
| title | Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study |
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