Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing
Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded...
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| Veröffentlicht in: | International journal of pharmaceutics 2013-01, Vol.441 (1-2), p.181-191 |
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| container_title | International journal of pharmaceutics |
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| creator | Boateng, Joshua S. Pawar, Harshavardhan V. Tetteh, John |
| description | Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling. |
| doi_str_mv | 10.1016/j.ijpharm.2012.11.045 |
| format | Article |
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Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2012.11.045</identifier><identifier>PMID: 23228898</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adhesiveness ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; anti-inflammatory agents ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antibacterial ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; carrageenan ; Carrageenan - chemistry ; Chronic Disease ; Delayed-Action Preparations ; Diclofenac - administration & dosage ; Diclofenac - pharmacology ; differential scanning calorimetry ; Drug Delivery Systems ; Elasticity ; Escherichia coli ; Film dressing ; Fourier transform infrared spectroscopy ; glycerol ; Glycerol - chemistry ; In vitro drug release ; Inflammation - drug therapy ; Inflammation - pathology ; long term effects ; Mucoadhesion ; pain ; Plasticiser ; Plasticizers - chemistry ; polyethylene glycol ; Polyethylene Glycols - chemistry ; Pseudomonas aeruginosa ; scanning electron microscopy ; solvents ; Solvents - chemistry ; Staphylococcus aureus ; streptomycin ; Streptomycin - administration & dosage ; Streptomycin - pharmacology ; Surface Properties ; Tensile Strength ; texture ; Time Factors ; tissue repair ; Wound healing ; Wound Healing - drug effects ; Wounds and Injuries - drug therapy ; Wounds and Injuries - microbiology ; Wounds and Injuries - pathology ; X-ray diffraction</subject><ispartof>International journal of pharmaceutics, 2013-01, Vol.441 (1-2), p.181-191</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-b5d6ad2f77ce0650b98f18057de5753c280938a5e717dd4d86500fb903ba3373</citedby><cites>FETCH-LOGICAL-c540t-b5d6ad2f77ce0650b98f18057de5753c280938a5e717dd4d86500fb903ba3373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517312010526$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23228898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boateng, Joshua S.</creatorcontrib><creatorcontrib>Pawar, Harshavardhan V.</creatorcontrib><creatorcontrib>Tetteh, John</creatorcontrib><title>Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling.</description><subject>Adhesiveness</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antibacterial</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>carrageenan</subject><subject>Carrageenan - chemistry</subject><subject>Chronic Disease</subject><subject>Delayed-Action Preparations</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - pharmacology</subject><subject>differential scanning calorimetry</subject><subject>Drug Delivery Systems</subject><subject>Elasticity</subject><subject>Escherichia coli</subject><subject>Film dressing</subject><subject>Fourier transform infrared spectroscopy</subject><subject>glycerol</subject><subject>Glycerol - chemistry</subject><subject>In vitro drug release</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - pathology</subject><subject>long term effects</subject><subject>Mucoadhesion</subject><subject>pain</subject><subject>Plasticiser</subject><subject>Plasticizers - chemistry</subject><subject>polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Pseudomonas aeruginosa</subject><subject>scanning electron microscopy</subject><subject>solvents</subject><subject>Solvents - chemistry</subject><subject>Staphylococcus aureus</subject><subject>streptomycin</subject><subject>Streptomycin - administration & dosage</subject><subject>Streptomycin - pharmacology</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>texture</subject><subject>Time Factors</subject><subject>tissue repair</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and Injuries - drug therapy</subject><subject>Wounds and Injuries - microbiology</subject><subject>Wounds and Injuries - pathology</subject><subject>X-ray diffraction</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-P1CAUxYnRuOPqR1D76EsrF0qhT8Zs_JdsoonrM6HlMsukhRHa1fkCfm6ZndHXfYLc_M65cA4hL4E2QKF7u2v8bn9r0twwCqwBaGgrHpENKMlr3sruMdlQLlUtQPIL8iznHaW0Y8CfkgvGGVOqVxvy51ucDvF3ZYKtRpOS2SIGE6rBZCyTOO9j9gtWzk9zZRPm7MO2zMNifDheTVh8PfsxxcGb6d7nfuSDm8w8myWmQxGu21y5mCp0DsfF32H1K66FvUUzFZvn5IkzU8YX5_OS3Hz8cHP1ub7--unL1fvrehQtXepB2M5Y5qQckXaCDr1yoKiQFoUUfGSK9lwZgRKkta1VhaFu6CkfDOeSX5I3J9t9ij9XzIuefR5xmkzAuGYNHEQHLYPuYZQpRtuedn1BxQktIeSc0Ol98rNJBw1UH8vSO30uSx_L0gC6lFV0r84r1mFG-1_1r50CvD4BzkRttsln_eN7cSifAsahP65-dyKwhHbnMek8egwjWp9KztpG_8Aj_gKUuLOb</recordid><startdate>20130130</startdate><enddate>20130130</enddate><creator>Boateng, Joshua S.</creator><creator>Pawar, Harshavardhan V.</creator><creator>Tetteh, John</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130130</creationdate><title>Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing</title><author>Boateng, Joshua S. ; Pawar, Harshavardhan V. ; Tetteh, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-b5d6ad2f77ce0650b98f18057de5753c280938a5e717dd4d86500fb903ba3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adhesiveness</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antibacterial</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - microbiology</topic><topic>carrageenan</topic><topic>Carrageenan - chemistry</topic><topic>Chronic Disease</topic><topic>Delayed-Action Preparations</topic><topic>Diclofenac - administration & dosage</topic><topic>Diclofenac - pharmacology</topic><topic>differential scanning calorimetry</topic><topic>Drug Delivery Systems</topic><topic>Elasticity</topic><topic>Escherichia coli</topic><topic>Film dressing</topic><topic>Fourier transform infrared spectroscopy</topic><topic>glycerol</topic><topic>Glycerol - chemistry</topic><topic>In vitro drug release</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - pathology</topic><topic>long term effects</topic><topic>Mucoadhesion</topic><topic>pain</topic><topic>Plasticiser</topic><topic>Plasticizers - chemistry</topic><topic>polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Pseudomonas aeruginosa</topic><topic>scanning electron microscopy</topic><topic>solvents</topic><topic>Solvents - chemistry</topic><topic>Staphylococcus aureus</topic><topic>streptomycin</topic><topic>Streptomycin - administration & dosage</topic><topic>Streptomycin - pharmacology</topic><topic>Surface Properties</topic><topic>Tensile Strength</topic><topic>texture</topic><topic>Time Factors</topic><topic>tissue repair</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and Injuries - drug therapy</topic><topic>Wounds and Injuries - microbiology</topic><topic>Wounds and Injuries - pathology</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boateng, Joshua S.</creatorcontrib><creatorcontrib>Pawar, Harshavardhan V.</creatorcontrib><creatorcontrib>Tetteh, John</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boateng, Joshua S.</au><au>Pawar, Harshavardhan V.</au><au>Tetteh, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2013-01-30</date><risdate>2013</risdate><volume>441</volume><issue>1-2</issue><spage>181</spage><epage>191</epage><pages>181-191</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23228898</pmid><doi>10.1016/j.ijpharm.2012.11.045</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2013-01, Vol.441 (1-2), p.181-191 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| subjects | Adhesiveness Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibacterial Bacterial Infections - drug therapy Bacterial Infections - microbiology carrageenan Carrageenan - chemistry Chronic Disease Delayed-Action Preparations Diclofenac - administration & dosage Diclofenac - pharmacology differential scanning calorimetry Drug Delivery Systems Elasticity Escherichia coli Film dressing Fourier transform infrared spectroscopy glycerol Glycerol - chemistry In vitro drug release Inflammation - drug therapy Inflammation - pathology long term effects Mucoadhesion pain Plasticiser Plasticizers - chemistry polyethylene glycol Polyethylene Glycols - chemistry Pseudomonas aeruginosa scanning electron microscopy solvents Solvents - chemistry Staphylococcus aureus streptomycin Streptomycin - administration & dosage Streptomycin - pharmacology Surface Properties Tensile Strength texture Time Factors tissue repair Wound healing Wound Healing - drug effects Wounds and Injuries - drug therapy Wounds and Injuries - microbiology Wounds and Injuries - pathology X-ray diffraction |
| title | Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing |
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