Thymidine glycol: the effect on DNA molecular structure and enzymatic processing

Thymine glycol (Tg) in DNA is a biologically active oxidative damage caused by ionizing radiation or oxidative stress. Due to chirality of C5 and C6 atoms, Tg exists as a mixture of two pairs of cis and trans diastereomers: 5R cis–trans pair (5R,6S; 5R,6R) and 5S cis–trans pair (5S,6R; 5S,6S). Of al...

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Veröffentlicht in:	Biochimie 2013-02, Vol.95 (2), p.134-147
Hauptverfasser:	Dolinnaya, Nina G., Kubareva, Elena A., Romanova, Elena A., Trikin, Roman M., Oretskaya, Tatiana S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alteration in DNA structure Base Pairing DNA - chemistry DNA - genetics DNA Damage DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA Repair DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Endonucleases - genetics Endonucleases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Humans Nucleic Acid Conformation Oligonucleotides - chemistry Oligonucleotides - genetics Oxidative DNA damage Protein Biosynthesis Stereoisomerism Tandem (clustered) lesions Thymidine - analogs & derivatives Thymidine - chemistry Thymidine - genetics Thymine glycol repair Transcription, Genetic Translesion synthesis
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