Hepatocyte growth factor is sequestered in dentine matrix and promotes regeneration-associated events in dental pulp cells

► HGF is sequestered in dentine matrix and solubilised by therapeutic pulp agents. ► HGF acts as a chemokine, inducing differentiation and mineralisation of pulp cells. ► HGF is likely important in signalling various aspects of dental pulp repair. Extracellular matrix of dentine contains a rich cock...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2013-02, Vol.61 (2), p.622-629
Hauptverfasser:	Tomson, Phillip L., Lumley, Philip J., Alexander, M. Yvonne, Smith, Anthony J., Cooper, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcification, Physiologic Cbfa-1 protein Cell culture Cell Differentiation Cells, Cultured Chemokines Chemotaxis Cytokines Data processing Dental pulp Dental Pulp - cytology Dental Pulp - metabolism Dentin - metabolism Dentine Differentiation Enzyme-linked immunosorbent assay Extracellular matrix Extracellular Matrix - metabolism gene expression regulation genes Hepatocyte growth factor Hepatocyte growth factor (HGF) Hepatocyte Growth Factor - metabolism hepatocyte growth factor receptor Humans Injuries Male Mesenchyme Mineral trioxide aggregate (MTA) Minerals Osteocalcin Osteopontin Proto-Oncogene Proteins c-met - metabolism Pulp Rats Rats, Wistar recruitment Regeneration RNA, Messenger - genetics RNA, Messenger - metabolism secretion solubilization Stem cells tissue repair tooth pulp Transcription factors Wound Healing
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