Ribavirin-Resistant Mutants of Human Enterovirus 71 Express a High Replication Fidelity Phenotype during Growth in Cell Culture
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| Veröffentlicht in: | Journal of Virology 2013-02, Vol.87 (3), p.1759-1769 |
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| container_title | Journal of Virology |
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| creator | Sadeghipour, Sara Bek, Emily J McMinn, Peter C |
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| doi_str_mv | 10.1128/JVI.02139-12 |
| format | Article |
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</description><subject>Amino Acid Substitution</subject><subject>Animals</subject><subject>Antiviral Agents - pharmacology</subject><subject>Cell Line</subject><subject>Cercopithecus aethiops</subject><subject>DNA-Directed RNA Polymerases - genetics</subject><subject>DNA-Directed RNA Polymerases - metabolism</subject><subject>Drug Resistance, Viral</subject><subject>Enterovirus A, Human - drug effects</subject><subject>Enterovirus A, Human - enzymology</subject><subject>Enterovirus A, Human - genetics</subject><subject>Enterovirus A, Human - physiology</subject><subject>Genome and Regulation of Viral Gene Expression</subject><subject>Human enterovirus 71</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Mutagenesis, Site-Directed</subject><subject>Mutation Rate</subject><subject>Poliovirus</subject><subject>Ribavirin - pharmacology</subject><subject>RNA, Viral - biosynthesis</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Serial Passage</subject><subject>Virus Replication</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0EokvhxhmZGwdSPHY-nAsSWm27RUWgFSBuluNMNq6ycWo7W_bEX8dlSwWnOcyjZz5eQl4COwPg8t3H75dnjIOoM-CPyAJYLbOigPwxWTDGeVYI-eOEPAvhmjHI8zJ_Sk64gKoQVbkgvza20Xvr7ZhtMNgQ9Rjpp_muBOo6up53eqSrMaJ3CZsDrYCufk4eQ6Caru22pxucBmt0tG6k57bFwcYD_dLj6OJhQtrOyb6lF97dxp7akS5xGOhyHuLs8Tl50ukh4Iv7ekq-na--LtfZ1eeLy-WHq8wUrI5ZWxrJG5QgqjavO4DCcNEIWRmZSzBNbbBpTMc0Qgmy1Y1gpawwr4XheVWgOCXvj95pbnbYGhyj14OavN1pf1BOW_V_Z7S92rq9EkWRQ1kmwZt7gXc3M4aodjaYdIke0c1BgYCiBCgFS-jbI2q8C8Fj9zAGmLrLTKXM1J_MFPCEv_p3tQf4b0gJeH0E-vTtW-tR6bBT13urZKWESlQtfgO5ZJ_j</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Sadeghipour, Sara</creator><creator>Bek, Emily J</creator><creator>McMinn, Peter C</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Ribavirin-Resistant Mutants of Human Enterovirus 71 Express a High Replication Fidelity Phenotype during Growth in Cell Culture</title><author>Sadeghipour, Sara ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>23175376</pmid><doi>10.1128/JVI.02139-12</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of Virology, 2013-02, Vol.87 (3), p.1759-1769 |
| issn | 0022-538X 1098-5514 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Amino Acid Substitution Animals Antiviral Agents - pharmacology Cell Line Cercopithecus aethiops DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Drug Resistance, Viral Enterovirus A, Human - drug effects Enterovirus A, Human - enzymology Enterovirus A, Human - genetics Enterovirus A, Human - physiology Genome and Regulation of Viral Gene Expression Human enterovirus 71 Humans Molecular Sequence Data Mutagenesis, Site-Directed Mutation Rate Poliovirus Ribavirin - pharmacology RNA, Viral - biosynthesis RNA, Viral - genetics Sequence Analysis, DNA Serial Passage Virus Replication |
| title | Ribavirin-Resistant Mutants of Human Enterovirus 71 Express a High Replication Fidelity Phenotype during Growth in Cell Culture |
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