Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats
The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2013-03, Vol.112 (3), p.186-191 |
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| creator | Jiang, Zhitao Xu, Bo Yang, Mowen Li, Zhaozhu Zhang, Yubo Jiang, Dapeng |
| description | The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ml/kg) and WR‐2721 (200 mg/kg), respectively, 15 min. before the start of gamma irradiation. Testis weight, testis dimensions, sperm count, sperm motility, apoptosis index and biochemical assays were assessed after a 4‐day initiation of irradiation. Testis weight, testis dimensions, sperm count, sperm motility in group II were significantly lower compared with those in the control group, whereas they were higher in the HRSS and WR‐2721 group. Apoptosis index was significantly increased in group II. Treatment of rats with HRSS and WR‐2721 significantly reduced the apoptosis index. On the other hand, irradiation markedly decreased activities of SOD. Activities of SOD were significantly improved when treated with HRSS and WR‐2721. Significant increase in the MDA level was observed in group II. MDA levels of group III and IV were significantly lowered when compared with group II. HRSS also played a significant role in the recovery of serum testosterone levels. The results from this experimental study suggest that hydrogen has a possible protective effect against radiation‐induced testicular damage. |
| doi_str_mv | 10.1111/bcpt.12016 |
| format | Article |
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Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ml/kg) and WR‐2721 (200 mg/kg), respectively, 15 min. before the start of gamma irradiation. Testis weight, testis dimensions, sperm count, sperm motility, apoptosis index and biochemical assays were assessed after a 4‐day initiation of irradiation. Testis weight, testis dimensions, sperm count, sperm motility in group II were significantly lower compared with those in the control group, whereas they were higher in the HRSS and WR‐2721 group. Apoptosis index was significantly increased in group II. Treatment of rats with HRSS and WR‐2721 significantly reduced the apoptosis index. On the other hand, irradiation markedly decreased activities of SOD. Activities of SOD were significantly improved when treated with HRSS and WR‐2721. Significant increase in the MDA level was observed in group II. MDA levels of group III and IV were significantly lowered when compared with group II. HRSS also played a significant role in the recovery of serum testosterone levels. The results from this experimental study suggest that hydrogen has a possible protective effect against radiation‐induced testicular damage.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12016</identifier><identifier>PMID: 22998562</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - radiation effects ; Biological and medical sciences ; gamma Radiation ; Gamma Rays - adverse effects ; Hydrogen ; Hydrogen - administration & dosage ; Hydrogen - pharmacology ; Hydrogen - therapeutic use ; In Situ Nick-End Labeling ; Male ; Medical sciences ; Motility ; Pharmacology. Drug treatments ; Radiation ; Radiation Injuries, Experimental - pathology ; Radiation Injuries, Experimental - prevention & control ; Radiation-Protective Agents - administration & dosage ; Radiation-Protective Agents - pharmacology ; Radiation-Protective Agents - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride - chemistry ; Solubility ; Sperm ; Sperm Count ; Sperm Motility - drug effects ; Sperm Motility - radiation effects ; Superoxide dismutase ; Testes ; Testis - drug effects ; Testis - injuries ; Testis - pathology ; Testis - radiation effects ; Testosterone ; Testosterone - blood</subject><ispartof>Basic & clinical pharmacology & toxicology, 2013-03, Vol.112 (3), p.186-191</ispartof><rights>2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society</rights><rights>2014 INIST-CNRS</rights><rights>2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.</rights><rights>Basic & Clinical Pharmacology & Toxicology © 2013 Nordic Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5226-6a148f19d9286c5244095e85a4861216d4e49ee2fbe88c946e427fdd6ce82ddb3</citedby><cites>FETCH-LOGICAL-c5226-6a148f19d9286c5244095e85a4861216d4e49ee2fbe88c946e427fdd6ce82ddb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.12016$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.12016$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26903880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22998562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Zhitao</creatorcontrib><creatorcontrib>Xu, Bo</creatorcontrib><creatorcontrib>Yang, Mowen</creatorcontrib><creatorcontrib>Li, Zhaozhu</creatorcontrib><creatorcontrib>Zhang, Yubo</creatorcontrib><creatorcontrib>Jiang, Dapeng</creatorcontrib><title>Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ml/kg) and WR‐2721 (200 mg/kg), respectively, 15 min. before the start of gamma irradiation. Testis weight, testis dimensions, sperm count, sperm motility, apoptosis index and biochemical assays were assessed after a 4‐day initiation of irradiation. Testis weight, testis dimensions, sperm count, sperm motility in group II were significantly lower compared with those in the control group, whereas they were higher in the HRSS and WR‐2721 group. Apoptosis index was significantly increased in group II. Treatment of rats with HRSS and WR‐2721 significantly reduced the apoptosis index. On the other hand, irradiation markedly decreased activities of SOD. Activities of SOD were significantly improved when treated with HRSS and WR‐2721. Significant increase in the MDA level was observed in group II. MDA levels of group III and IV were significantly lowered when compared with group II. HRSS also played a significant role in the recovery of serum testosterone levels. The results from this experimental study suggest that hydrogen has a possible protective effect against radiation‐induced testicular damage.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>Biological and medical sciences</subject><subject>gamma Radiation</subject><subject>Gamma Rays - adverse effects</subject><subject>Hydrogen</subject><subject>Hydrogen - administration & dosage</subject><subject>Hydrogen - pharmacology</subject><subject>Hydrogen - therapeutic use</subject><subject>In Situ Nick-End Labeling</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motility</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiation</subject><subject>Radiation Injuries, Experimental - pathology</subject><subject>Radiation Injuries, Experimental - prevention & control</subject><subject>Radiation-Protective Agents - administration & dosage</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Radiation-Protective Agents - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sodium Chloride - chemistry</subject><subject>Solubility</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Sperm Motility - drug effects</subject><subject>Sperm Motility - radiation effects</subject><subject>Superoxide dismutase</subject><subject>Testes</subject><subject>Testis - drug effects</subject><subject>Testis - injuries</subject><subject>Testis - pathology</subject><subject>Testis - radiation effects</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1q3DAQB3BRGppk20sfoBhKIQQ21ciSLB3TzScsNJTt2cjSeHHwx1ayCb7lEfKMeZJos5st5JDoIiF-zIz0J-Qr0BOI62dhV_0JMAryAzmAjLNppnj6cXdOxT45DOGWUpZxoJ_IPmNaKyHZAZnf-K5H21ddmxRjcjU63y2xTU6XpmpDn1yapjHJHzM-3j9ct26w6JIFhr6yQ218cmYas8SkaiPpw2eyV5o64JftPiF_L84Xs6vp_Pfl9ex0PrWCMTmVBrgqQTvNlIxXnFMtUAnDlQQG0nHkGpGVBSplNZfIWVY6Jy0q5lyRTsjRpu7Kd_-GOE3eVMFiXZsWuyHkkIKQAALS9ylTWap0xkSk31_R227wbXzIWgku4_A8quONsr4LwWOZr3zVGD_mQPN1HPk6jvw5joi_bUsORYNuR1_-P4IfW2CCNXXpTWur8N9JTVOlaHSwcXdVjeMbLfNfs5vFpvkT4ZGgKQ</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Jiang, Zhitao</creator><creator>Xu, Bo</creator><creator>Yang, Mowen</creator><creator>Li, Zhaozhu</creator><creator>Zhang, Yubo</creator><creator>Jiang, Dapeng</creator><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats</title><author>Jiang, Zhitao ; Xu, Bo ; Yang, Mowen ; Li, Zhaozhu ; Zhang, Yubo ; Jiang, Dapeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5226-6a148f19d9286c5244095e85a4861216d4e49ee2fbe88c946e427fdd6ce82ddb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - radiation effects</topic><topic>Biological and medical sciences</topic><topic>gamma Radiation</topic><topic>Gamma Rays - adverse effects</topic><topic>Hydrogen</topic><topic>Hydrogen - administration & dosage</topic><topic>Hydrogen - pharmacology</topic><topic>Hydrogen - therapeutic use</topic><topic>In Situ Nick-End Labeling</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motility</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiation</topic><topic>Radiation Injuries, Experimental - pathology</topic><topic>Radiation Injuries, Experimental - prevention & control</topic><topic>Radiation-Protective Agents - administration & dosage</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Radiation-Protective Agents - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sodium Chloride - chemistry</topic><topic>Solubility</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Sperm Motility - drug effects</topic><topic>Sperm Motility - radiation effects</topic><topic>Superoxide dismutase</topic><topic>Testes</topic><topic>Testis - drug effects</topic><topic>Testis - injuries</topic><topic>Testis - pathology</topic><topic>Testis - radiation effects</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Zhitao</creatorcontrib><creatorcontrib>Xu, Bo</creatorcontrib><creatorcontrib>Yang, Mowen</creatorcontrib><creatorcontrib>Li, Zhaozhu</creatorcontrib><creatorcontrib>Zhang, Yubo</creatorcontrib><creatorcontrib>Jiang, Dapeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Zhitao</au><au>Xu, Bo</au><au>Yang, Mowen</au><au>Li, Zhaozhu</au><au>Zhang, Yubo</au><au>Jiang, Dapeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2013-03</date><risdate>2013</risdate><volume>112</volume><issue>3</issue><spage>186</spage><epage>191</epage><pages>186-191</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ml/kg) and WR‐2721 (200 mg/kg), respectively, 15 min. before the start of gamma irradiation. Testis weight, testis dimensions, sperm count, sperm motility, apoptosis index and biochemical assays were assessed after a 4‐day initiation of irradiation. Testis weight, testis dimensions, sperm count, sperm motility in group II were significantly lower compared with those in the control group, whereas they were higher in the HRSS and WR‐2721 group. Apoptosis index was significantly increased in group II. Treatment of rats with HRSS and WR‐2721 significantly reduced the apoptosis index. On the other hand, irradiation markedly decreased activities of SOD. Activities of SOD were significantly improved when treated with HRSS and WR‐2721. Significant increase in the MDA level was observed in group II. MDA levels of group III and IV were significantly lowered when compared with group II. HRSS also played a significant role in the recovery of serum testosterone levels. The results from this experimental study suggest that hydrogen has a possible protective effect against radiation‐induced testicular damage.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>22998562</pmid><doi>10.1111/bcpt.12016</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences gamma Radiation Gamma Rays - adverse effects Hydrogen Hydrogen - administration & dosage Hydrogen - pharmacology Hydrogen - therapeutic use In Situ Nick-End Labeling Male Medical sciences Motility Pharmacology. Drug treatments Radiation Radiation Injuries, Experimental - pathology Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - pharmacology Radiation-Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Sodium Chloride - chemistry Solubility Sperm Sperm Count Sperm Motility - drug effects Sperm Motility - radiation effects Superoxide dismutase Testes Testis - drug effects Testis - injuries Testis - pathology Testis - radiation effects Testosterone Testosterone - blood |
| title | Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats |
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