Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo
This work aims to investigate the antiproliferative properties of Allium sivasicum (AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses....
Gespeichert in:
| Veröffentlicht in: | Molecular biology reports 2013, Vol.40 (1), p.597-604 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 604 |
|---|---|
| container_issue | 1 |
| container_start_page | 597 |
| container_title | Molecular biology reports |
| container_volume | 40 |
| creator | Tepe, Bektas Tuncer, Ersin Saraydın, Serpil Unver Özer, Hatice Şen, Metin Karadayi, Kursat Inan, Deniz Sahin Karadayi, Sule Polat, Zübeyde Akpulat, Askin Duman, Mustafa Koksal, Binnur Turan, Mustafa |
| description | This work aims to investigate the antiproliferative properties of
Allium sivasicum
(AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that
A. sivasicum
has antitumoral potential against breast cancer. |
| doi_str_mv | 10.1007/s11033-012-2098-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315610233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2857822411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-c91b2e0fd61074d459ec71044fe36d343fdfdc119e485e4dbf0940c971727e903</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVoaLZJf0AvRZBLL05m9GGtjktI08CWXpKz8Mqj4MW2Usle6L-PFqclBHrSiHnmneFh7AvCFQKY64wIUlaAohJg11V9wlaojayUNesPbAUSsFJrjWfsU857AFBo9Ed2JiTUWgi9Yj8349RN8xBT03MKgfyUeQx80_fdPPDcHZrc-VLFke8SNXnivhk9Jd6N_NBNKfJmbJfPIV6w09D0mT6_vufs8fvtw82Pavvr7v5ms628Aj1V3uJOEIS2RjCqVdqSNwhKBZJ1K5UMbWg9oqVyPKl2F8Aq8NagEYYsyHP2bcl9TvH3THlyQ5c99X0zUpyzQ4m6ZAspC3r5Dt3HOY3lOoeirjVatKpQuFA-xZwTBfecuqFJfxyCO7p2i2tXXLuja1eXma-vyfNuoPbfxF-5BRALkEtrfKL0ZvV_U18AE0OH1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1266519194</pqid></control><display><type>article</type><title>Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tepe, Bektas ; Tuncer, Ersin ; Saraydın, Serpil Unver ; Özer, Hatice ; Şen, Metin ; Karadayi, Kursat ; Inan, Deniz Sahin ; Karadayi, Sule ; Polat, Zübeyde ; Akpulat, Askin ; Duman, Mustafa ; Koksal, Binnur ; Turan, Mustafa</creator><creatorcontrib>Tepe, Bektas ; Tuncer, Ersin ; Saraydın, Serpil Unver ; Özer, Hatice ; Şen, Metin ; Karadayi, Kursat ; Inan, Deniz Sahin ; Karadayi, Sule ; Polat, Zübeyde ; Akpulat, Askin ; Duman, Mustafa ; Koksal, Binnur ; Turan, Mustafa</creatorcontrib><description>This work aims to investigate the antiproliferative properties of
Allium sivasicum
(AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that
A. sivasicum
has antitumoral potential against breast cancer.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-012-2098-6</identifier><identifier>PMID: 23065225</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Allium ; Allium - chemistry ; Animal Anatomy ; Animal Biochemistry ; Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - toxicity ; Apoptosis - drug effects ; Biomedical and Life Sciences ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer therapies ; Caspase 7 - metabolism ; Cell Line, Tumor ; Cell Survival - drug effects ; Cytotoxicity ; Female ; Garlic ; Histology ; Humans ; Inhibitory Concentration 50 ; Life Sciences ; MCF-7 Cells ; Morphology ; Natural products ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Rats ; Tumor Burden - drug effects</subject><ispartof>Molecular biology reports, 2013, Vol.40 (1), p.597-604</ispartof><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c91b2e0fd61074d459ec71044fe36d343fdfdc119e485e4dbf0940c971727e903</citedby><cites>FETCH-LOGICAL-c405t-c91b2e0fd61074d459ec71044fe36d343fdfdc119e485e4dbf0940c971727e903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-012-2098-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-012-2098-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23065225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tepe, Bektas</creatorcontrib><creatorcontrib>Tuncer, Ersin</creatorcontrib><creatorcontrib>Saraydın, Serpil Unver</creatorcontrib><creatorcontrib>Özer, Hatice</creatorcontrib><creatorcontrib>Şen, Metin</creatorcontrib><creatorcontrib>Karadayi, Kursat</creatorcontrib><creatorcontrib>Inan, Deniz Sahin</creatorcontrib><creatorcontrib>Karadayi, Sule</creatorcontrib><creatorcontrib>Polat, Zübeyde</creatorcontrib><creatorcontrib>Akpulat, Askin</creatorcontrib><creatorcontrib>Duman, Mustafa</creatorcontrib><creatorcontrib>Koksal, Binnur</creatorcontrib><creatorcontrib>Turan, Mustafa</creatorcontrib><title>Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>This work aims to investigate the antiproliferative properties of
Allium sivasicum
(AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that
A. sivasicum
has antitumoral potential against breast cancer.</description><subject>Allium</subject><subject>Allium - chemistry</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - toxicity</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Caspase 7 - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Garlic</subject><subject>Histology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Life Sciences</subject><subject>MCF-7 Cells</subject><subject>Morphology</subject><subject>Natural products</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Rats</subject><subject>Tumor Burden - drug effects</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1r3DAQhkVoaLZJf0AvRZBLL05m9GGtjktI08CWXpKz8Mqj4MW2Usle6L-PFqclBHrSiHnmneFh7AvCFQKY64wIUlaAohJg11V9wlaojayUNesPbAUSsFJrjWfsU857AFBo9Ed2JiTUWgi9Yj8349RN8xBT03MKgfyUeQx80_fdPPDcHZrc-VLFke8SNXnivhk9Jd6N_NBNKfJmbJfPIV6w09D0mT6_vufs8fvtw82Pavvr7v5ms628Aj1V3uJOEIS2RjCqVdqSNwhKBZJ1K5UMbWg9oqVyPKl2F8Aq8NagEYYsyHP2bcl9TvH3THlyQ5c99X0zUpyzQ4m6ZAspC3r5Dt3HOY3lOoeirjVatKpQuFA-xZwTBfecuqFJfxyCO7p2i2tXXLuja1eXma-vyfNuoPbfxF-5BRALkEtrfKL0ZvV_U18AE0OH1A</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Tepe, Bektas</creator><creator>Tuncer, Ersin</creator><creator>Saraydın, Serpil Unver</creator><creator>Özer, Hatice</creator><creator>Şen, Metin</creator><creator>Karadayi, Kursat</creator><creator>Inan, Deniz Sahin</creator><creator>Karadayi, Sule</creator><creator>Polat, Zübeyde</creator><creator>Akpulat, Askin</creator><creator>Duman, Mustafa</creator><creator>Koksal, Binnur</creator><creator>Turan, Mustafa</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2013</creationdate><title>Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo</title><author>Tepe, Bektas ; Tuncer, Ersin ; Saraydın, Serpil Unver ; Özer, Hatice ; Şen, Metin ; Karadayi, Kursat ; Inan, Deniz Sahin ; Karadayi, Sule ; Polat, Zübeyde ; Akpulat, Askin ; Duman, Mustafa ; Koksal, Binnur ; Turan, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c91b2e0fd61074d459ec71044fe36d343fdfdc119e485e4dbf0940c971727e903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Allium</topic><topic>Allium - chemistry</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - toxicity</topic><topic>Apoptosis - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Caspase 7 - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Garlic</topic><topic>Histology</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Life Sciences</topic><topic>MCF-7 Cells</topic><topic>Morphology</topic><topic>Natural products</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - toxicity</topic><topic>Rats</topic><topic>Tumor Burden - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tepe, Bektas</creatorcontrib><creatorcontrib>Tuncer, Ersin</creatorcontrib><creatorcontrib>Saraydın, Serpil Unver</creatorcontrib><creatorcontrib>Özer, Hatice</creatorcontrib><creatorcontrib>Şen, Metin</creatorcontrib><creatorcontrib>Karadayi, Kursat</creatorcontrib><creatorcontrib>Inan, Deniz Sahin</creatorcontrib><creatorcontrib>Karadayi, Sule</creatorcontrib><creatorcontrib>Polat, Zübeyde</creatorcontrib><creatorcontrib>Akpulat, Askin</creatorcontrib><creatorcontrib>Duman, Mustafa</creatorcontrib><creatorcontrib>Koksal, Binnur</creatorcontrib><creatorcontrib>Turan, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tepe, Bektas</au><au>Tuncer, Ersin</au><au>Saraydın, Serpil Unver</au><au>Özer, Hatice</au><au>Şen, Metin</au><au>Karadayi, Kursat</au><au>Inan, Deniz Sahin</au><au>Karadayi, Sule</au><au>Polat, Zübeyde</au><au>Akpulat, Askin</au><au>Duman, Mustafa</au><au>Koksal, Binnur</au><au>Turan, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2013</date><risdate>2013</risdate><volume>40</volume><issue>1</issue><spage>597</spage><epage>604</epage><pages>597-604</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>This work aims to investigate the antiproliferative properties of
Allium sivasicum
(AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that
A. sivasicum
has antitumoral potential against breast cancer.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23065225</pmid><doi>10.1007/s11033-012-2098-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 2013, Vol.40 (1), p.597-604 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1315610233 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Allium Allium - chemistry Animal Anatomy Animal Biochemistry Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity Apoptosis - drug effects Biomedical and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Caspase 7 - metabolism Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Female Garlic Histology Humans Inhibitory Concentration 50 Life Sciences MCF-7 Cells Morphology Natural products Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - toxicity Rats Tumor Burden - drug effects |
| title | Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T09%3A15%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antitumoral%20effects%20of%20Allium%20sivasicum%20on%20breast%20cancer%20in%20vitro%20and%20in%20vivo&rft.jtitle=Molecular%20biology%20reports&rft.au=Tepe,%20Bektas&rft.date=2013&rft.volume=40&rft.issue=1&rft.spage=597&rft.epage=604&rft.pages=597-604&rft.issn=0301-4851&rft.eissn=1573-4978&rft_id=info:doi/10.1007/s11033-012-2098-6&rft_dat=%3Cproquest_cross%3E2857822411%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1266519194&rft_id=info:pmid/23065225&rfr_iscdi=true |