Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs
We investigated the contribution of JAK2 rs2203724 and STAT3 rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of JAK2 rs2203724 and STAT3 rs1053023 genoty...
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| Veröffentlicht in: | Molecular biology reports 2013, Vol.40 (1), p.585-589 |
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| creator | Messoudi, Safia Al-Sulaiti, Manar A. Al-Busaidi, Amna S. Dendana, Maryam Nsiri, Brahim Almawi, Wassim Y. Mahjoub, Touhami |
| description | We investigated the contribution of
JAK2
rs2203724 and
STAT3
rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of
JAK2
rs2203724 and
STAT3
rs1053023 genotypes were in Hardy–Weinberg equilibrium (HWE) in both communities, while mild deviation from HWE was noted for rs1053004 in Tunisians but not Bahraini.
JAK2
rs2203724 was not associated with IRM in either community, while
STAT3
rs1053023 was positively associated with IRM in both Bahraini and Tunisian women.
STAT3
rs1053004 displayed mixed association: it was positively associated with IRM in Bahraini (
P
|
| doi_str_mv | 10.1007/s11033-012-2096-8 |
| format | Article |
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JAK2
rs2203724 and
STAT3
rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of
JAK2
rs2203724 and
STAT3
rs1053023 genotypes were in Hardy–Weinberg equilibrium (HWE) in both communities, while mild deviation from HWE was noted for rs1053004 in Tunisians but not Bahraini.
JAK2
rs2203724 was not associated with IRM in either community, while
STAT3
rs1053023 was positively associated with IRM in both Bahraini and Tunisian women.
STAT3
rs1053004 displayed mixed association: it was positively associated with IRM in Bahraini (
P
< 0.001), but not Tunisian women (
P
= 0.10). Genotype association confirmed the association of both
STAT3
variants with IRM under additive, dominant, and recessive models, while the association of
STAT3
rs1053023 was seen under additive and dominant, but not recessive models in Tunisians. The contribution of
JAK2
and
STAT3
variants to IRM susceptibility must be evaluated regarding specific variants, and the ethnic/racial background.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-012-2096-8</identifier><identifier>PMID: 23065274</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Abortion, Habitual - ethnology ; Abortion, Habitual - genetics ; Adult ; Alleles ; Animal Anatomy ; Animal Biochemistry ; Arabs - genetics ; Bahrain ; Biomedical and Life Sciences ; Case-Control Studies ; Female ; Gene Frequency ; Genetic markers ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Histology ; Humans ; Janus Kinase 2 - genetics ; Life Sciences ; Miscarriage ; Morphology ; Odds Ratio ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Pregnancy ; Risk factors ; STAT3 Transcription Factor - genetics ; Tunisia</subject><ispartof>Molecular biology reports, 2013, Vol.40 (1), p.585-589</ispartof><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-47276c4e35b5964cdd6d8a173c6e625b3499e0647540d4d05e8af83d5b9dea193</citedby><cites>FETCH-LOGICAL-c405t-47276c4e35b5964cdd6d8a173c6e625b3499e0647540d4d05e8af83d5b9dea193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-012-2096-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-012-2096-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23065274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Messoudi, Safia</creatorcontrib><creatorcontrib>Al-Sulaiti, Manar A.</creatorcontrib><creatorcontrib>Al-Busaidi, Amna S.</creatorcontrib><creatorcontrib>Dendana, Maryam</creatorcontrib><creatorcontrib>Nsiri, Brahim</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><creatorcontrib>Mahjoub, Touhami</creatorcontrib><title>Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>We investigated the contribution of
JAK2
rs2203724 and
STAT3
rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of
JAK2
rs2203724 and
STAT3
rs1053023 genotypes were in Hardy–Weinberg equilibrium (HWE) in both communities, while mild deviation from HWE was noted for rs1053004 in Tunisians but not Bahraini.
JAK2
rs2203724 was not associated with IRM in either community, while
STAT3
rs1053023 was positively associated with IRM in both Bahraini and Tunisian women.
STAT3
rs1053004 displayed mixed association: it was positively associated with IRM in Bahraini (
P
< 0.001), but not Tunisian women (
P
= 0.10). Genotype association confirmed the association of both
STAT3
variants with IRM under additive, dominant, and recessive models, while the association of
STAT3
rs1053023 was seen under additive and dominant, but not recessive models in Tunisians. The contribution of
JAK2
and
STAT3
variants to IRM susceptibility must be evaluated regarding specific variants, and the ethnic/racial background.</description><subject>Abortion, Habitual - ethnology</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Alleles</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Arabs - genetics</subject><subject>Bahrain</subject><subject>Biomedical and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Histology</subject><subject>Humans</subject><subject>Janus Kinase 2 - genetics</subject><subject>Life Sciences</subject><subject>Miscarriage</subject><subject>Morphology</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Risk factors</subject><subject>STAT3 Transcription Factor - genetics</subject><subject>Tunisia</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1vEzEQhi0EoqHwA7ggS1y4LMz4e48hKhSoxIFwXnl3J6mrxBtsb6Xe-Ok4pCCEhDj5MM_7jEcvY88RXiOAfZMRQcoGUDQCWtO4B2yB2spGtdY9ZAuQgI1yGs_Yk5xvAECh1Y_ZmZBgtLBqwb6vplhS6OcSpsinDf-4_CS4jyP_sl6uJb_1KfhYMi8TL9fEtxSphIHnOQ90KKEPu1DujsFEw5wSxcL3IQ8-1dyWuN9Pccvf-uvkQww_xes5hlylfJl8n5-yRxu_y_Ts_j1nX99drFeXzdXn9x9Wy6tmUKBLo6ywZlAkda9bo4ZxNKPzaOVgyAjdS9W2BEZZrWBUI2hyfuPkqPt2JI-tPGevTt5Dmr7NlEt3_Cbtdj7SNOcOJWqDIMD-HxXSanAApqIv_0JvpjnFekiljNEoHWKl8EQNaco50aY7pLD36a5D6I5Ndqcmu9pkd2yyczXz4t4893safyd-VVcBcQJyHcUtpT9W_9P6A9zfp8w</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Messoudi, Safia</creator><creator>Al-Sulaiti, Manar A.</creator><creator>Al-Busaidi, Amna S.</creator><creator>Dendana, Maryam</creator><creator>Nsiri, Brahim</creator><creator>Almawi, Wassim Y.</creator><creator>Mahjoub, Touhami</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs</title><author>Messoudi, Safia ; Al-Sulaiti, Manar A. ; Al-Busaidi, Amna S. ; Dendana, Maryam ; Nsiri, Brahim ; Almawi, Wassim Y. ; Mahjoub, Touhami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-47276c4e35b5964cdd6d8a173c6e625b3499e0647540d4d05e8af83d5b9dea193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abortion, Habitual - ethnology</topic><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Alleles</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Arabs - genetics</topic><topic>Bahrain</topic><topic>Biomedical and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic markers</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Histology</topic><topic>Humans</topic><topic>Janus Kinase 2 - genetics</topic><topic>Life Sciences</topic><topic>Miscarriage</topic><topic>Morphology</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Risk factors</topic><topic>STAT3 Transcription Factor - genetics</topic><topic>Tunisia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Messoudi, Safia</creatorcontrib><creatorcontrib>Al-Sulaiti, Manar A.</creatorcontrib><creatorcontrib>Al-Busaidi, Amna S.</creatorcontrib><creatorcontrib>Dendana, Maryam</creatorcontrib><creatorcontrib>Nsiri, Brahim</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><creatorcontrib>Mahjoub, Touhami</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Messoudi, Safia</au><au>Al-Sulaiti, Manar A.</au><au>Al-Busaidi, Amna S.</au><au>Dendana, Maryam</au><au>Nsiri, Brahim</au><au>Almawi, Wassim Y.</au><au>Mahjoub, Touhami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2013</date><risdate>2013</risdate><volume>40</volume><issue>1</issue><spage>585</spage><epage>589</epage><pages>585-589</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>We investigated the contribution of
JAK2
rs2203724 and
STAT3
rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of
JAK2
rs2203724 and
STAT3
rs1053023 genotypes were in Hardy–Weinberg equilibrium (HWE) in both communities, while mild deviation from HWE was noted for rs1053004 in Tunisians but not Bahraini.
JAK2
rs2203724 was not associated with IRM in either community, while
STAT3
rs1053023 was positively associated with IRM in both Bahraini and Tunisian women.
STAT3
rs1053004 displayed mixed association: it was positively associated with IRM in Bahraini (
P
< 0.001), but not Tunisian women (
P
= 0.10). Genotype association confirmed the association of both
STAT3
variants with IRM under additive, dominant, and recessive models, while the association of
STAT3
rs1053023 was seen under additive and dominant, but not recessive models in Tunisians. The contribution of
JAK2
and
STAT3
variants to IRM susceptibility must be evaluated regarding specific variants, and the ethnic/racial background.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23065274</pmid><doi>10.1007/s11033-012-2096-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 2013, Vol.40 (1), p.585-589 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1315610207 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abortion, Habitual - ethnology Abortion, Habitual - genetics Adult Alleles Animal Anatomy Animal Biochemistry Arabs - genetics Bahrain Biomedical and Life Sciences Case-Control Studies Female Gene Frequency Genetic markers Genetic Predisposition to Disease Genotype Genotype & phenotype Histology Humans Janus Kinase 2 - genetics Life Sciences Miscarriage Morphology Odds Ratio Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Pregnancy Risk factors STAT3 Transcription Factor - genetics Tunisia |
| title | Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs |
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