Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine

Cisplatin (CP) is a widely used antineoplastic drug that exhibits gastrointestinal toxicity. We have previously shown that administration of a single dose of CP results in a decrease in the activities of several brush border membrane (BBM) enzymes, induces oxidative stress and alters the activities...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2013-01, Vol.65 (1-2), p.21-25
Hauptverfasser:	Arivarasu, N.A., Priyamvada, Shubha, Mahmood, Riaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antioxidant system antioxidants Antioxidants - administration & dosage Antioxidants - metabolism Antioxidants - pharmacology body weight Brush border membrane Caffeic acid Caffeic Acids - administration & dosage Caffeic Acids - pharmacology catalase Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects drug toxicity glucose-6-phosphate 1-dehydrogenase glutathione peroxidase glutathione transferase glutathione-disulfide reductase Injections, Intraperitoneal Intestine Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - ultrastructure lipid peroxidation Lipid Peroxidation - drug effects Male microvilli Microvilli - drug effects Microvilli - enzymology nutritional intervention oral administration Oxidative stress Rats Rats, Wistar reducing agents small intestine Sulfhydryl Compounds - metabolism sulfhydryl groups superoxide dismutase
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