Variants in folate pathway genes as modulators of genetic instability and lung cancer risk

Genetic instability plays a crucial role in cancer development. The genetic stability of the cell as well as DNA methylation status could be modulated by folate levels. Several studies suggested associations between polymorphisms in folate genes and alterations in protein expression and variations i...

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Veröffentlicht in:	Genes chromosomes & cancer 2011-01, Vol.50 (1), p.1-12
Hauptverfasser:	Piskac-Collier, Amanda L., Monroy, Claudia, Lopez, Mirtha S., Cortes, Andrea, Etzel, Carol J., Greisinger, Anthony J., Spitz, Margaret R., El-Zein, Randa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Aged Cancer Carcinogens Case-Control Studies Chromosomes DNA DNA methylation Female Ferredoxin-NADP Reductase - genetics Folic acid Folic Acid - genetics Folic Acid - metabolism Gene polymorphism Gene Regulatory Networks Genetic Predisposition to Disease Genomic Instability Genotyping Glycine Hydroxymethyltransferase - genetics Glycine Hydroxymethyltransferase - metabolism Humans Linkage Disequilibrium Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lymphocytes Male Metabolic Networks and Pathways - genetics Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism Micronucleus Tests Middle Aged Odds Ratio Phenotype Polymorphism, Single Nucleotide Proteins Regression Analysis Serum levels Single-nucleotide polymorphism Tobacco Tumor Cells, Cultured
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