Glycyrrhetinic acid inhibits Porphyromonas gingivalis lipopolysaccharide-induced vascular permeability via the suppression of interleukin-8

Objective Porphyromonas gingivalis is a major periodontopathogen that plays a role in the pathogenesis of periodontal disease. In this study, we investigated the effect of 18alpha-glycyrrhetinic acid (18α-GA), a natural triterpenoid compound derived from licorice root extract, on P. gingivalis lipop...

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Veröffentlicht in:	Inflammation research 2013-02, Vol.62 (2), p.145-154
Hauptverfasser:	Kim, Su-Ryun, Jeon, Hwa-Jin, Park, Hyun-Joo, Kim, Mi-Kyoung, Choi, Woo-Soo, Jang, Hye-Ock, Bae, Soo-Kyung, Jeong, Chul-Ho, Bae, Moon-Kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Biomedical and Life Sciences Biomedicine Capillary Permeability - drug effects Cells, Cultured Dermatology Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Glycyrrhetinic Acid - pharmacology Glycyrrhiza glabra Humans I Kappa B kinase Immunology Inflammatory diseases Interleukin 8 Interleukin-8 - metabolism Lipopolysaccharides Neurology NF- Kappa B protein NF-kappa B - metabolism Nuclear transport Original Research Paper Periodontal diseases Periodontitis Permeability Pharmacology/Toxicology Phosphorylation Polymerase chain reaction Porphyromonas gingivalis Reverse transcription Rheumatology RNA Roots triterpenoids Vascular diseases Western blotting
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