The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility
In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a sca...
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| Veröffentlicht in: | Dental Materials Journal 2012/11/30, Vol.31(6), pp.1087-1096 |
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| creator | HAMADA, Yoshinosuke FUJITANI, Wataru KAWAGUCHI, Naomasa DAITO, Kiyoshi NIIDO, Tsutsu UCHINAKA, Ayako MORI, Seiji KOJIMA, Yoshihisa MANABE, Masashi NISHIDA, Kiheiji ARITA, Kenji NAKANO, Takayoshi MATSUURA, Nariaki |
| description | In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength. |
| doi_str_mv | 10.4012/dmj.2012-117 |
| format | Article |
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Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2012-117</identifier><identifier>PMID: 23207220</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>3T3 Cells ; Absorbable Implants ; Animals ; Biocompatibility ; Bioengineering ; Bone Regeneration ; Calcium Phosphates - chemical synthesis ; Calcium Phosphates - pharmacology ; Cell Adhesion - drug effects ; Cell Proliferation - drug effects ; Dentistry ; Drug Combinations ; Lactic Acid - chemical synthesis ; Lactic Acid - pharmacology ; Male ; Materials Testing ; Mice ; Osteoblasts - drug effects ; PLLA/OCP composite ; Polyesters ; Polymers - chemical synthesis ; Polymers - pharmacology ; Porosity ; Rats ; Rats, Sprague-Dawley ; Tissue Engineering ; Tissue Scaffolds</subject><ispartof>Dental Materials Journal, 2012/11/30, Vol.31(6), pp.1087-1096</ispartof><rights>2012 The Japanese Society for Dental Materials and Devices</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c676t-ac43bc942562b87b67e522aa3692148ef857dd87e6e13c33c84e07c957f8cf823</citedby><cites>FETCH-LOGICAL-c676t-ac43bc942562b87b67e522aa3692148ef857dd87e6e13c33c84e07c957f8cf823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23207220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAMADA, Yoshinosuke</creatorcontrib><creatorcontrib>FUJITANI, Wataru</creatorcontrib><creatorcontrib>KAWAGUCHI, Naomasa</creatorcontrib><creatorcontrib>DAITO, Kiyoshi</creatorcontrib><creatorcontrib>NIIDO, Tsutsu</creatorcontrib><creatorcontrib>UCHINAKA, Ayako</creatorcontrib><creatorcontrib>MORI, Seiji</creatorcontrib><creatorcontrib>KOJIMA, Yoshihisa</creatorcontrib><creatorcontrib>MANABE, Masashi</creatorcontrib><creatorcontrib>NISHIDA, Kiheiji</creatorcontrib><creatorcontrib>ARITA, Kenji</creatorcontrib><creatorcontrib>NAKANO, Takayoshi</creatorcontrib><creatorcontrib>MATSUURA, Nariaki</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Medical Economics and Management</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine and Health Science</creatorcontrib><creatorcontrib>Graduate School of Engineering</creatorcontrib><creatorcontrib>Department of Molecular Pathology</creatorcontrib><creatorcontrib>Osaka University</creatorcontrib><creatorcontrib>Department of Pediatric Dentistry</creatorcontrib><creatorcontrib>Osaka Dental University</creatorcontrib><creatorcontrib>Department of Cardiovascular Pathology</creatorcontrib><creatorcontrib>Department of Materials Science and Engineering</creatorcontrib><title>The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.</description><subject>3T3 Cells</subject><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Bioengineering</subject><subject>Bone Regeneration</subject><subject>Calcium Phosphates - chemical synthesis</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Dentistry</subject><subject>Drug Combinations</subject><subject>Lactic Acid - chemical synthesis</subject><subject>Lactic Acid - pharmacology</subject><subject>Male</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Osteoblasts - drug effects</subject><subject>PLLA/OCP composite</subject><subject>Polyesters</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - pharmacology</subject><subject>Porosity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1P3DAQxa0KVLa0N84oRw4EPHZiO0dAQCutVA70bDnOpPEqiYOdIO1_Xy_L7rU-jD_m5zdPj5ALoDcFBXbbDJsblg45gPxCVqAU5MAFnJAVZUrmRVnIM_Itxg2lRSWU-krOGGdUMkZXxLx2mE0BJxPM7PyY-TZ7Wa_vbq3prVuGbOp8nDozY9Zt6-CazPph8tGlBzM2mZtjhu-mX46_a-d3SLrXrnfz9js5bU0f8cfnfk7-PD2-PvzM17-ffz3crXMrpJhzYwte26pgpWC1krWQWDJmDBcVg0Jhq0rZNEqiQOCWc6sKpNJWpWyVbRXj5-RqrzsF_7ZgnPXgosW-NyP6JWrgUAqqSqr-j7K0OEBVJvR6j9rgYwzY6im4wYStBqp3-euUv97lr1P-Cb_8VF7qAZsjfAg8Ac97IHVdytiPvRtRb_wSxpSObra0wfEgSSkHKjRlVRqnZCqVYMCp-HB2v1faxNn8xeMoE2Zne_zwxUGLXTn4OzZtZ4LGkf8DQ_CuYg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>HAMADA, Yoshinosuke</creator><creator>FUJITANI, Wataru</creator><creator>KAWAGUCHI, Naomasa</creator><creator>DAITO, Kiyoshi</creator><creator>NIIDO, Tsutsu</creator><creator>UCHINAKA, Ayako</creator><creator>MORI, Seiji</creator><creator>KOJIMA, Yoshihisa</creator><creator>MANABE, Masashi</creator><creator>NISHIDA, Kiheiji</creator><creator>ARITA, Kenji</creator><creator>NAKANO, Takayoshi</creator><creator>MATSUURA, Nariaki</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>2012</creationdate><title>The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility</title><author>HAMADA, Yoshinosuke ; 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Mater. J.</addtitle><date>2012</date><risdate>2012</risdate><volume>31</volume><issue>6</issue><spage>1087</spage><epage>1096</epage><pages>1087-1096</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>23207220</pmid><doi>10.4012/dmj.2012-117</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0287-4547 |
| ispartof | Dental Materials Journal, 2012/11/30, Vol.31(6), pp.1087-1096 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3 Cells Absorbable Implants Animals Biocompatibility Bioengineering Bone Regeneration Calcium Phosphates - chemical synthesis Calcium Phosphates - pharmacology Cell Adhesion - drug effects Cell Proliferation - drug effects Dentistry Drug Combinations Lactic Acid - chemical synthesis Lactic Acid - pharmacology Male Materials Testing Mice Osteoblasts - drug effects PLLA/OCP composite Polyesters Polymers - chemical synthesis Polymers - pharmacology Porosity Rats Rats, Sprague-Dawley Tissue Engineering Tissue Scaffolds |
| title | The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility |
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