Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2

► DnaJC7 is associated with DNA-binding domain of p53. ► DnaJC7 enhances transcriptional and growth-suppressive activities of p53. ► DnaJC7 stabilizes p53 by inhibiting complex formation between p53 and MDM2. Tumor suppressor p53 plays a critical role in the regulation of DNA damage response. Upon s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2013-01, Vol.430 (3), p.1034-1039
Hauptverfasser:	Kubo, Natsumi, Wu, Dan, Yoshihara, Yukari, Sang, Meixiang, Nakagawara, Akira, Ozaki, Toshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cercopithecus aethiops COS Cells DnaJC7 Half-Life HSP40 Heat-Shock Proteins - metabolism Humans MDM2 p53 Protein Stability Proto-Oncogene Proteins c-mdm2 - metabolism TPR2 Transcription, Genetic Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Two-hybrid Two-Hybrid System Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!