Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio)
Butachlor, a chloracetamide herbicide, is widely used in China. In the present study, paired adult male and female zebrafish (Danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/L) for 30 days, and the effects on reproduction and endocrine disruption were evaluated...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2013-01, Vol.65 (1-2), p.205-209 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Chang, Juhua Liu, Shaoying Zhou, Shengli Wang, Minghua Zhu, Guonian |
| description | Butachlor, a chloracetamide herbicide, is widely used in China. In the present study, paired adult male and female zebrafish (Danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/L) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (CF), gonadosomatic index (GSI), liver somatic index (LSI), plasma vitellogenin (VTG), sex steroids and thyroid hormone levels as endpoints. Our results showed that the mean fecundity rates were significantly decreased at 50 and 100μg/L butachlor during the 30-day exposure period. At the end of the exposure period, no significant changes were observed in CF and LSI in both females and males, while GSI was significantly reduced in males at 50 and 100μg/L butachlor. At 100μg/L butachlor, plasma testosterone (T) and 17β-estradiol (E2) levels were significantly decreased in females, while plasma VTG level was significantly increased in males. Plasma thyroxine (T4) and triiodothyronine (T3) levels were significantly increased at 50 and 100μg/L butachlor in males, and at 100μg/L in females. This work demonstrated that butachlor adversely affected the normal reproductive success of zebrafish, and disrupted the thyroid and sex steroid endocrine systems, which provides the basis for the estimated ecological risk during butachlor exposure. |
| doi_str_mv | 10.1016/j.etp.2011.08.007 |
| format | Article |
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In the present study, paired adult male and female zebrafish (Danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/L) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (CF), gonadosomatic index (GSI), liver somatic index (LSI), plasma vitellogenin (VTG), sex steroids and thyroid hormone levels as endpoints. Our results showed that the mean fecundity rates were significantly decreased at 50 and 100μg/L butachlor during the 30-day exposure period. At the end of the exposure period, no significant changes were observed in CF and LSI in both females and males, while GSI was significantly reduced in males at 50 and 100μg/L butachlor. At 100μg/L butachlor, plasma testosterone (T) and 17β-estradiol (E2) levels were significantly decreased in females, while plasma VTG level was significantly increased in males. Plasma thyroxine (T4) and triiodothyronine (T3) levels were significantly increased at 50 and 100μg/L butachlor in males, and at 100μg/L in females. This work demonstrated that butachlor adversely affected the normal reproductive success of zebrafish, and disrupted the thyroid and sex steroid endocrine systems, which provides the basis for the estimated ecological risk during butachlor exposure.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2011.08.007</identifier><identifier>PMID: 21920721</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Acetanilides - toxicity ; adults ; Animals ; Butachlor ; condition factor ; Danio rerio ; Dose-Response Relationship, Drug ; Endocrine Disruptors - toxicity ; estradiol ; exposure duration ; fecundity ; Female ; females ; Fertility - drug effects ; Freshwater ; Gonadal Steroid Hormones - blood ; gonadosomatic index ; liver ; Male ; males ; Reproduction ; risk ; Sex steroid ; testosterone ; Thyroid hormone ; Thyroid Hormones - blood ; Time Factors ; triiodothyronine ; Vitellogenin ; Vitellogenins - blood ; Zebrafish ; Zebrafish - blood ; Zebrafish - physiology</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2013-01, Vol.65 (1-2), p.205-209</ispartof><rights>2011 Elsevier GmbH</rights><rights>Copyright © 2011 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-8344aeaad7c408a43fdcc2897ed11f139e8006c2ba90eb02dd64d1cae486de633</citedby><cites>FETCH-LOGICAL-c410t-8344aeaad7c408a43fdcc2897ed11f139e8006c2ba90eb02dd64d1cae486de633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etp.2011.08.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21920721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Juhua</creatorcontrib><creatorcontrib>Liu, Shaoying</creatorcontrib><creatorcontrib>Zhou, Shengli</creatorcontrib><creatorcontrib>Wang, Minghua</creatorcontrib><creatorcontrib>Zhu, Guonian</creatorcontrib><title>Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio)</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Butachlor, a chloracetamide herbicide, is widely used in China. In the present study, paired adult male and female zebrafish (Danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/L) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (CF), gonadosomatic index (GSI), liver somatic index (LSI), plasma vitellogenin (VTG), sex steroids and thyroid hormone levels as endpoints. Our results showed that the mean fecundity rates were significantly decreased at 50 and 100μg/L butachlor during the 30-day exposure period. At the end of the exposure period, no significant changes were observed in CF and LSI in both females and males, while GSI was significantly reduced in males at 50 and 100μg/L butachlor. At 100μg/L butachlor, plasma testosterone (T) and 17β-estradiol (E2) levels were significantly decreased in females, while plasma VTG level was significantly increased in males. Plasma thyroxine (T4) and triiodothyronine (T3) levels were significantly increased at 50 and 100μg/L butachlor in males, and at 100μg/L in females. This work demonstrated that butachlor adversely affected the normal reproductive success of zebrafish, and disrupted the thyroid and sex steroid endocrine systems, which provides the basis for the estimated ecological risk during butachlor exposure.</description><subject>Acetanilides - toxicity</subject><subject>adults</subject><subject>Animals</subject><subject>Butachlor</subject><subject>condition factor</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine Disruptors - toxicity</subject><subject>estradiol</subject><subject>exposure duration</subject><subject>fecundity</subject><subject>Female</subject><subject>females</subject><subject>Fertility - drug effects</subject><subject>Freshwater</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>gonadosomatic index</subject><subject>liver</subject><subject>Male</subject><subject>males</subject><subject>Reproduction</subject><subject>risk</subject><subject>Sex steroid</subject><subject>testosterone</subject><subject>Thyroid hormone</subject><subject>Thyroid Hormones - blood</subject><subject>Time Factors</subject><subject>triiodothyronine</subject><subject>Vitellogenin</subject><subject>Vitellogenins - blood</subject><subject>Zebrafish</subject><subject>Zebrafish - blood</subject><subject>Zebrafish - physiology</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi1ERbeFB-ACOZZDwozteBNxQqWlSJU4QCVulmOPWa-y8WInlejT49UWjvQ08uj7f40-M_YaoUFA9X7b0LxvOCA20DUA62dshQq7GqUQz9kKegk173txys5y3gJw6Ft8wU459hzWHFfsx5X3ZOdcRV8Ny2zsZoypilOVaJ-iW-wcysNMrtrEtIsTVSPd05irULZuGefqgYZkfMib6uKTmUIsyRTiu5fsxJsx06vHec7urq--X97Ut18_f7n8eFtbiTDXnZDSkDFubSV0RgrvrOVdvyaH6FH01AEoywfTAw3AnVPSoTUkO-VICXHOLo695dxfC-VZ70K2NI5morhkjQJbBepg4UmUcxCKd4oXFI-oTTHnRF7vU9iZ9Fsj6IN7vdXFvT6419Dp4r5k3jzWL8OO3L_EX9kFeHsEvIna_Ewh67tvpaGFUtjKti3EhyNRDNN9oKSzDTRZciGVX9Iuhv8c8Aei3514</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Chang, Juhua</creator><creator>Liu, Shaoying</creator><creator>Zhou, Shengli</creator><creator>Wang, Minghua</creator><creator>Zhu, Guonian</creator><general>Elsevier GmbH</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>201301</creationdate><title>Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio)</title><author>Chang, Juhua ; Liu, Shaoying ; Zhou, Shengli ; Wang, Minghua ; Zhu, Guonian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-8344aeaad7c408a43fdcc2897ed11f139e8006c2ba90eb02dd64d1cae486de633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetanilides - toxicity</topic><topic>adults</topic><topic>Animals</topic><topic>Butachlor</topic><topic>condition factor</topic><topic>Danio rerio</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine Disruptors - toxicity</topic><topic>estradiol</topic><topic>exposure duration</topic><topic>fecundity</topic><topic>Female</topic><topic>females</topic><topic>Fertility - drug effects</topic><topic>Freshwater</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>gonadosomatic index</topic><topic>liver</topic><topic>Male</topic><topic>males</topic><topic>Reproduction</topic><topic>risk</topic><topic>Sex steroid</topic><topic>testosterone</topic><topic>Thyroid hormone</topic><topic>Thyroid Hormones - blood</topic><topic>Time Factors</topic><topic>triiodothyronine</topic><topic>Vitellogenin</topic><topic>Vitellogenins - blood</topic><topic>Zebrafish</topic><topic>Zebrafish - blood</topic><topic>Zebrafish - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Juhua</creatorcontrib><creatorcontrib>Liu, Shaoying</creatorcontrib><creatorcontrib>Zhou, Shengli</creatorcontrib><creatorcontrib>Wang, Minghua</creatorcontrib><creatorcontrib>Zhu, Guonian</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Juhua</au><au>Liu, Shaoying</au><au>Zhou, Shengli</au><au>Wang, Minghua</au><au>Zhu, Guonian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio)</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>65</volume><issue>1-2</issue><spage>205</spage><epage>209</epage><pages>205-209</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Butachlor, a chloracetamide herbicide, is widely used in China. In the present study, paired adult male and female zebrafish (Danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/L) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (CF), gonadosomatic index (GSI), liver somatic index (LSI), plasma vitellogenin (VTG), sex steroids and thyroid hormone levels as endpoints. Our results showed that the mean fecundity rates were significantly decreased at 50 and 100μg/L butachlor during the 30-day exposure period. At the end of the exposure period, no significant changes were observed in CF and LSI in both females and males, while GSI was significantly reduced in males at 50 and 100μg/L butachlor. At 100μg/L butachlor, plasma testosterone (T) and 17β-estradiol (E2) levels were significantly decreased in females, while plasma VTG level was significantly increased in males. Plasma thyroxine (T4) and triiodothyronine (T3) levels were significantly increased at 50 and 100μg/L butachlor in males, and at 100μg/L in females. This work demonstrated that butachlor adversely affected the normal reproductive success of zebrafish, and disrupted the thyroid and sex steroid endocrine systems, which provides the basis for the estimated ecological risk during butachlor exposure.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>21920721</pmid><doi>10.1016/j.etp.2011.08.007</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetanilides - toxicity adults Animals Butachlor condition factor Danio rerio Dose-Response Relationship, Drug Endocrine Disruptors - toxicity estradiol exposure duration fecundity Female females Fertility - drug effects Freshwater Gonadal Steroid Hormones - blood gonadosomatic index liver Male males Reproduction risk Sex steroid testosterone Thyroid hormone Thyroid Hormones - blood Time Factors triiodothyronine Vitellogenin Vitellogenins - blood Zebrafish Zebrafish - blood Zebrafish - physiology |
| title | Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio) |
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