Dose-dependent effect of histamine on liver function markers in immunized rabbits
The present study was designed to delineate the hepatotoxicological roles of histamine dose-dependently in immunized rabbits. The cohort comprised of three groups (II, III and IV), containing 18 rabbits each, and received subcutaneous histamine 50μg/kg, 100μg/kg and 200μg/kg, respectively for 10 day...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2012-11, Vol.64 (7-8), p.875-881 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Tripathi, Trivendra Shahid, Mohammad Raza, Adil Khan, Haris M. Khan, Rahat Ali Mahdi, Abbas Ali Siddiqui, Mashiatullah Malik, Abida Khan, Aijaz Ahmed |
| description | The present study was designed to delineate the hepatotoxicological roles of histamine dose-dependently in immunized rabbits.
The cohort comprised of three groups (II, III and IV), containing 18 rabbits each, and received subcutaneous histamine 50μg/kg, 100μg/kg and 200μg/kg, respectively for 10 days (b.i.d., starting from 3 days prior to immunization until 7 days after immunization). Group I (control, n=18) received subcutaneous sterile distilled water for 10 days. They were subsequently immunized at day 3 with intravenous injection of SRBC (1×109cells/ml). Blood samples were collected on pre-immunization (pre-I) day 0, as well as on days 7-, 14-, 21-, 28- and 58-post-immunization (post-I). Biochemical parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin [total bilirubin (TB), direct bilirubin (DB) and indirect bilirubin (IB)] were determined.
Groups II and IV revealed a significant decrease (on day 0-pre-I) and a significant increase (on days 7-, 14-, 21-, 28- and 58-post-I) in ALT and AST levels, when compared with the corresponding values of groups I and III while group II showed a significant increase in ALT and AST levels as compared to group IV. ALP levels in groups II, III and IV showed a significant enhancement when compared with group I. Moreover, results of TB, DB and IB demonstrated increased levels in group III when compared with groups I, II and IV. The results were found statistically significant (p |
| doi_str_mv | 10.1016/j.etp.2011.03.010 |
| format | Article |
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The cohort comprised of three groups (II, III and IV), containing 18 rabbits each, and received subcutaneous histamine 50μg/kg, 100μg/kg and 200μg/kg, respectively for 10 days (b.i.d., starting from 3 days prior to immunization until 7 days after immunization). Group I (control, n=18) received subcutaneous sterile distilled water for 10 days. They were subsequently immunized at day 3 with intravenous injection of SRBC (1×109cells/ml). Blood samples were collected on pre-immunization (pre-I) day 0, as well as on days 7-, 14-, 21-, 28- and 58-post-immunization (post-I). Biochemical parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin [total bilirubin (TB), direct bilirubin (DB) and indirect bilirubin (IB)] were determined.
Groups II and IV revealed a significant decrease (on day 0-pre-I) and a significant increase (on days 7-, 14-, 21-, 28- and 58-post-I) in ALT and AST levels, when compared with the corresponding values of groups I and III while group II showed a significant increase in ALT and AST levels as compared to group IV. ALP levels in groups II, III and IV showed a significant enhancement when compared with group I. Moreover, results of TB, DB and IB demonstrated increased levels in group III when compared with groups I, II and IV. The results were found statistically significant (p<0.05).
Short-term treatment of histamine produces dose-dependent differential patterns of hepatic dysfunctions suggestive mild liver degeneration warranting further long-term studies.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2011.03.010</identifier><identifier>PMID: 21515037</identifier><language>eng</language><publisher>Munich: Elsevier GmbH</publisher><subject>Alanine aminotransferase ; alanine transaminase ; Alkaline phosphatase ; Animals ; Aspartate aminotransferase ; aspartate transaminase ; Bilirubin ; Biological and medical sciences ; Biomarkers - analysis ; blood ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - immunology ; dose response ; Dose-Response Relationship, Immunologic ; Histamine ; Histamine - administration & dosage ; Histamine - immunology ; Histamine - toxicity ; Histamine Agonists - administration & dosage ; Histamine Agonists - immunology ; Histamine Agonists - toxicity ; Immunization ; intravenous injection ; Investigative techniques, diagnostic techniques (general aspects) ; liver ; Liver - drug effects ; Liver - enzymology ; Liver - immunology ; liver function ; Liver Function Tests ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rabbit ; Rabbits ; Time Factors</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2012-11, Vol.64 (7-8), p.875-881</ispartof><rights>2011 Elsevier GmbH</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-87b3d8f5b5e82e6bccb60468b5f277a60a6e0bd571c7095a346beef74ecdae5a3</citedby><cites>FETCH-LOGICAL-c440t-87b3d8f5b5e82e6bccb60468b5f277a60a6e0bd571c7095a346beef74ecdae5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etp.2011.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26580825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21515037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tripathi, Trivendra</creatorcontrib><creatorcontrib>Shahid, Mohammad</creatorcontrib><creatorcontrib>Raza, Adil</creatorcontrib><creatorcontrib>Khan, Haris M.</creatorcontrib><creatorcontrib>Khan, Rahat Ali</creatorcontrib><creatorcontrib>Mahdi, Abbas Ali</creatorcontrib><creatorcontrib>Siddiqui, Mashiatullah</creatorcontrib><creatorcontrib>Malik, Abida</creatorcontrib><creatorcontrib>Khan, Aijaz Ahmed</creatorcontrib><title>Dose-dependent effect of histamine on liver function markers in immunized rabbits</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>The present study was designed to delineate the hepatotoxicological roles of histamine dose-dependently in immunized rabbits.
The cohort comprised of three groups (II, III and IV), containing 18 rabbits each, and received subcutaneous histamine 50μg/kg, 100μg/kg and 200μg/kg, respectively for 10 days (b.i.d., starting from 3 days prior to immunization until 7 days after immunization). Group I (control, n=18) received subcutaneous sterile distilled water for 10 days. They were subsequently immunized at day 3 with intravenous injection of SRBC (1×109cells/ml). Blood samples were collected on pre-immunization (pre-I) day 0, as well as on days 7-, 14-, 21-, 28- and 58-post-immunization (post-I). Biochemical parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin [total bilirubin (TB), direct bilirubin (DB) and indirect bilirubin (IB)] were determined.
Groups II and IV revealed a significant decrease (on day 0-pre-I) and a significant increase (on days 7-, 14-, 21-, 28- and 58-post-I) in ALT and AST levels, when compared with the corresponding values of groups I and III while group II showed a significant increase in ALT and AST levels as compared to group IV. ALP levels in groups II, III and IV showed a significant enhancement when compared with group I. Moreover, results of TB, DB and IB demonstrated increased levels in group III when compared with groups I, II and IV. The results were found statistically significant (p<0.05).
Short-term treatment of histamine produces dose-dependent differential patterns of hepatic dysfunctions suggestive mild liver degeneration warranting further long-term studies.</description><subject>Alanine aminotransferase</subject><subject>alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Animals</subject><subject>Aspartate aminotransferase</subject><subject>aspartate transaminase</subject><subject>Bilirubin</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>blood</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - immunology</subject><subject>dose response</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Histamine</subject><subject>Histamine - administration & dosage</subject><subject>Histamine - immunology</subject><subject>Histamine - toxicity</subject><subject>Histamine Agonists - administration & dosage</subject><subject>Histamine Agonists - immunology</subject><subject>Histamine Agonists - toxicity</subject><subject>Immunization</subject><subject>intravenous injection</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - immunology</subject><subject>liver function</subject><subject>Liver Function Tests</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Rabbit</subject><subject>Rabbits</subject><subject>Time Factors</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAQgK0KRLeFH9BL8QWpl4RxHDuJOKHylCqhqvRs-TEGL4mz2Ekl-uvrardw4zQa6ZvXN4ScMagZMPl2W-OyqxtgrAZeA4MjsmGS9RVrOX9GNjC0UDXDwI_JSc5bgAYGwV6Q44YJJoB3G3L9Yc5YOdxhdBgXit6jXejs6c-QFz2FiHSOdAx3mKhfo11CSSedfmHKNEQapmmN4R4dTdqYsOSX5LnXY8ZXh3hKbj99_H75pbr69vnr5furyrYtLFXfGe56L4zAvkFprDUSWtkb4Zuu0xK0RDBOdMx2ZWvNW2kQfdeidRpLfkou9n13af69Yl7UFLLFcdQR5zUrxpmQIAYJBWV71KY554Re7VIoN_xRDNSjSbVVxaR6NKmAq2Ky1Jwf2q9mQve34kldAd4cAJ2tHn3S0Yb8j5Oih74RhXu957yelf6RCnN7UyYJKINFy2Uh3u0JLLruAiaVbcBo0YVUnqHcHP6z6AOHoZqh</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Tripathi, Trivendra</creator><creator>Shahid, Mohammad</creator><creator>Raza, Adil</creator><creator>Khan, Haris M.</creator><creator>Khan, Rahat Ali</creator><creator>Mahdi, Abbas Ali</creator><creator>Siddiqui, Mashiatullah</creator><creator>Malik, Abida</creator><creator>Khan, Aijaz Ahmed</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20121101</creationdate><title>Dose-dependent effect of histamine on liver function markers in immunized rabbits</title><author>Tripathi, Trivendra ; Shahid, Mohammad ; Raza, Adil ; Khan, Haris M. ; Khan, Rahat Ali ; Mahdi, Abbas Ali ; Siddiqui, Mashiatullah ; Malik, Abida ; Khan, Aijaz Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-87b3d8f5b5e82e6bccb60468b5f277a60a6e0bd571c7095a346beef74ecdae5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alanine aminotransferase</topic><topic>alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Animals</topic><topic>Aspartate aminotransferase</topic><topic>aspartate transaminase</topic><topic>Bilirubin</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>blood</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Chemical and Drug Induced Liver Injury - immunology</topic><topic>dose response</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Histamine</topic><topic>Histamine - administration & dosage</topic><topic>Histamine - immunology</topic><topic>Histamine - toxicity</topic><topic>Histamine Agonists - administration & dosage</topic><topic>Histamine Agonists - immunology</topic><topic>Histamine Agonists - toxicity</topic><topic>Immunization</topic><topic>intravenous injection</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - immunology</topic><topic>liver function</topic><topic>Liver Function Tests</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Rabbit</topic><topic>Rabbits</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tripathi, Trivendra</creatorcontrib><creatorcontrib>Shahid, Mohammad</creatorcontrib><creatorcontrib>Raza, Adil</creatorcontrib><creatorcontrib>Khan, Haris M.</creatorcontrib><creatorcontrib>Khan, Rahat Ali</creatorcontrib><creatorcontrib>Mahdi, Abbas Ali</creatorcontrib><creatorcontrib>Siddiqui, Mashiatullah</creatorcontrib><creatorcontrib>Malik, Abida</creatorcontrib><creatorcontrib>Khan, Aijaz Ahmed</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tripathi, Trivendra</au><au>Shahid, Mohammad</au><au>Raza, Adil</au><au>Khan, Haris M.</au><au>Khan, Rahat Ali</au><au>Mahdi, Abbas Ali</au><au>Siddiqui, Mashiatullah</au><au>Malik, Abida</au><au>Khan, Aijaz Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-dependent effect of histamine on liver function markers in immunized rabbits</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>64</volume><issue>7-8</issue><spage>875</spage><epage>881</epage><pages>875-881</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>The present study was designed to delineate the hepatotoxicological roles of histamine dose-dependently in immunized rabbits.
The cohort comprised of three groups (II, III and IV), containing 18 rabbits each, and received subcutaneous histamine 50μg/kg, 100μg/kg and 200μg/kg, respectively for 10 days (b.i.d., starting from 3 days prior to immunization until 7 days after immunization). Group I (control, n=18) received subcutaneous sterile distilled water for 10 days. They were subsequently immunized at day 3 with intravenous injection of SRBC (1×109cells/ml). Blood samples were collected on pre-immunization (pre-I) day 0, as well as on days 7-, 14-, 21-, 28- and 58-post-immunization (post-I). Biochemical parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin [total bilirubin (TB), direct bilirubin (DB) and indirect bilirubin (IB)] were determined.
Groups II and IV revealed a significant decrease (on day 0-pre-I) and a significant increase (on days 7-, 14-, 21-, 28- and 58-post-I) in ALT and AST levels, when compared with the corresponding values of groups I and III while group II showed a significant increase in ALT and AST levels as compared to group IV. ALP levels in groups II, III and IV showed a significant enhancement when compared with group I. Moreover, results of TB, DB and IB demonstrated increased levels in group III when compared with groups I, II and IV. The results were found statistically significant (p<0.05).
Short-term treatment of histamine produces dose-dependent differential patterns of hepatic dysfunctions suggestive mild liver degeneration warranting further long-term studies.</abstract><cop>Munich</cop><pub>Elsevier GmbH</pub><pmid>21515037</pmid><doi>10.1016/j.etp.2011.03.010</doi><tpages>7</tpages></addata></record> |
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| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2012-11, Vol.64 (7-8), p.875-881 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alanine aminotransferase alanine transaminase Alkaline phosphatase Animals Aspartate aminotransferase aspartate transaminase Bilirubin Biological and medical sciences Biomarkers - analysis blood Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology dose response Dose-Response Relationship, Immunologic Histamine Histamine - administration & dosage Histamine - immunology Histamine - toxicity Histamine Agonists - administration & dosage Histamine Agonists - immunology Histamine Agonists - toxicity Immunization intravenous injection Investigative techniques, diagnostic techniques (general aspects) liver Liver - drug effects Liver - enzymology Liver - immunology liver function Liver Function Tests Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rabbit Rabbits Time Factors |
| title | Dose-dependent effect of histamine on liver function markers in immunized rabbits |
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