Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia

Abstract We report an autopsy case of progressive supranuclear palsy (PSP) that clinically showed only slowly progressive and symmetric upper motor neuron syndrome over a disease course of 12 years. A female patient initially exhibited dysarthria at the age of 65, followed by gait disturbance and dy...

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Veröffentlicht in:	Journal of the neurological sciences 2012-12, Vol.323 (1), p.147-153
Hauptverfasser:	Nagao, Shigeto, Yokota, Osamu, Nanba, Reiko, Takata, Hiroshi, Haraguchi, Takashi, Ishizu, Hideki, Ikeda, Chikako, Takeda, Naoya, Oshima, Etsuko, Sakane, Katsuaki, Terada, Seishi, Ihara, Yuetsu, Uchitomi, Yosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Astrocytes - ultrastructure Biological and medical sciences Coiled Bodies - ultrastructure Deglutition Disorders - etiology Diagnosis, Differential Diagnostic Errors Disease Progression DNA-Binding Proteins - analysis Dysarthria - etiology Female Frontal Lobe - pathology Gait Disorders, Neurologic - etiology Gliosis - etiology Gliosis - pathology Humans Medical sciences Motor neuron disease Motor Neuron Disease - diagnosis Motor Neuron Disease - etiology Motor Neurons - ultrastructure Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Muscle Spasticity - etiology Neurofibrillary Tangles - ultrastructure Neurology Primary lateral sclerosis Progressive supranuclear palsy Pseudobulbar palsy Pyramidal signs Reflex, Abnormal Silver Staining Supranuclear Palsy, Progressive - complications Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - pathology Supranuclear Palsy, Progressive - physiopathology Supranuclear Palsy, Progressive - psychology Symptom Assessment tau Proteins - analysis TDP-43 Proteinopathies - diagnosis
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