MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS
Abstract Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes befo...
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| Veröffentlicht in: | Journal of the neurological sciences 2012-12, Vol.323 (1), p.173-177 |
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| creator | Wang, Zhaoxia Xiao, Jiangxi Xie, Sheng Zhao, Danhua Liu, Xiwei Zhang, Jue Yuan, Yun Huang, Yining |
| description | Abstract Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress. |
| doi_str_mv | 10.1016/j.jns.2012.09.011 |
| format | Article |
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Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2012.09.011</identifier><identifier>PMID: 23062409</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acidosis, Lactic - etiology ; Adolescent ; Biological and medical sciences ; Brain - metabolism ; Brain - pathology ; Brain mapping ; Case-Control Studies ; Cerebral blood flow ; Cerebrovascular Circulation ; Child ; Diagnosis, Differential ; DNA Mutational Analysis ; DNA, Mitochondrial - genetics ; Dysarthria - etiology ; Epilepsies, Partial - etiology ; Female ; Headache - etiology ; Humans ; Hypoxia, Brain - etiology ; Hypoxia, Brain - physiopathology ; Magnetic Resonance Imaging ; Medical sciences ; MELAS Syndrome - blood ; MELAS Syndrome - complications ; MELAS Syndrome - genetics ; MELAS Syndrome - physiopathology ; Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes ; Mutation, Missense ; Neurology ; Oxygen - metabolism ; Oxygen Consumption ; Oxygen extraction fraction ; Paresis - etiology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of the neurological sciences, 2012-12, Vol.323 (1), p.173-177</ispartof><rights>Elsevier B.V.</rights><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-31c52186e2f07a8efcb2a0f056a3a1785cb48f96890428c8130c098b2a535c8d3</citedby><cites>FETCH-LOGICAL-c471t-31c52186e2f07a8efcb2a0f056a3a1785cb48f96890428c8130c098b2a535c8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2012.09.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26598211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23062409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhaoxia</creatorcontrib><creatorcontrib>Xiao, Jiangxi</creatorcontrib><creatorcontrib>Xie, Sheng</creatorcontrib><creatorcontrib>Zhao, Danhua</creatorcontrib><creatorcontrib>Liu, Xiwei</creatorcontrib><creatorcontrib>Zhang, Jue</creatorcontrib><creatorcontrib>Yuan, Yun</creatorcontrib><creatorcontrib>Huang, Yining</creatorcontrib><title>MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Abstract Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress.</description><subject>Acidosis, Lactic - etiology</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain mapping</subject><subject>Case-Control Studies</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Child</subject><subject>Diagnosis, Differential</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Dysarthria - etiology</subject><subject>Epilepsies, Partial - etiology</subject><subject>Female</subject><subject>Headache - etiology</subject><subject>Humans</subject><subject>Hypoxia, Brain - etiology</subject><subject>Hypoxia, Brain - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>MELAS Syndrome - blood</subject><subject>MELAS Syndrome - complications</subject><subject>MELAS Syndrome - genetics</subject><subject>MELAS Syndrome - physiopathology</subject><subject>Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes</subject><subject>Mutation, Missense</subject><subject>Neurology</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Consumption</subject><subject>Oxygen extraction fraction</subject><subject>Paresis - etiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoso7rj6A7yR3AjetJ4kkzZFEJZl_YBZBFdB8CKk6amkk0nGpF2df2_qjApe6NW5ed43hyenKB5TqCjQ-vlYjT5VDCiroK2A0jvFispGlkJKfrdYATBWCgqfzooHKY0AUEvZ3i_OGIearaFdFZ-v3xO81W7Wkw2ehIEYjNhF7Uj4fviCnuxw0l1wNu2I9j3pXAg9GVz4RqwnaYphi6WzWyS4tyn0mJaS66vNxc3D4t6gXcJHp3lefHx19eHyTbl59_rt5cWmNOuGTiWnRjAqa2QDNFriYDqmYQBRa65pI4Xp1nJoa9nCmkkjKQcDrcyQ4MLInp8Xz469-xi-zpgmtbPJoHPaY5iTopyKOteJ5v8oZawG2TDIKD2iJoaUIg5qH-1Ox4OioBb9alRZv1r0K2hV1p8zT071c7fD_nfil-8MPD0BOhnthqi9sekPV4tWsp9FL44cZm-3FqNKxqI32NuIZlJ9sP9c4-VfaeOst_nBLR4wjWGOPn-IoirljLpZ7mQ5E8oABHDBfwDit7Vr</recordid><startdate>20121215</startdate><enddate>20121215</enddate><creator>Wang, Zhaoxia</creator><creator>Xiao, Jiangxi</creator><creator>Xie, Sheng</creator><creator>Zhao, Danhua</creator><creator>Liu, Xiwei</creator><creator>Zhang, Jue</creator><creator>Yuan, Yun</creator><creator>Huang, Yining</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20121215</creationdate><title>MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS</title><author>Wang, Zhaoxia ; Xiao, Jiangxi ; Xie, Sheng ; Zhao, Danhua ; Liu, Xiwei ; Zhang, Jue ; Yuan, Yun ; Huang, Yining</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-31c52186e2f07a8efcb2a0f056a3a1785cb48f96890428c8130c098b2a535c8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acidosis, Lactic - etiology</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain mapping</topic><topic>Case-Control Studies</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Child</topic><topic>Diagnosis, Differential</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Dysarthria - etiology</topic><topic>Epilepsies, Partial - etiology</topic><topic>Female</topic><topic>Headache - etiology</topic><topic>Humans</topic><topic>Hypoxia, Brain - etiology</topic><topic>Hypoxia, Brain - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>MELAS Syndrome - blood</topic><topic>MELAS Syndrome - complications</topic><topic>MELAS Syndrome - genetics</topic><topic>MELAS Syndrome - physiopathology</topic><topic>Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes</topic><topic>Mutation, Missense</topic><topic>Neurology</topic><topic>Oxygen - metabolism</topic><topic>Oxygen Consumption</topic><topic>Oxygen extraction fraction</topic><topic>Paresis - etiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhaoxia</creatorcontrib><creatorcontrib>Xiao, Jiangxi</creatorcontrib><creatorcontrib>Xie, Sheng</creatorcontrib><creatorcontrib>Zhao, Danhua</creatorcontrib><creatorcontrib>Liu, Xiwei</creatorcontrib><creatorcontrib>Zhang, Jue</creatorcontrib><creatorcontrib>Yuan, Yun</creatorcontrib><creatorcontrib>Huang, Yining</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhaoxia</au><au>Xiao, Jiangxi</au><au>Xie, Sheng</au><au>Zhao, Danhua</au><au>Liu, Xiwei</au><au>Zhang, Jue</au><au>Yuan, Yun</au><au>Huang, Yining</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2012-12-15</date><risdate>2012</risdate><volume>323</volume><issue>1</issue><spage>173</spage><epage>177</epage><pages>173-177</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Abstract Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>23062409</pmid><doi>10.1016/j.jns.2012.09.011</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 2012-12, Vol.323 (1), p.173-177 |
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| subjects | Acidosis, Lactic - etiology Adolescent Biological and medical sciences Brain - metabolism Brain - pathology Brain mapping Case-Control Studies Cerebral blood flow Cerebrovascular Circulation Child Diagnosis, Differential DNA Mutational Analysis DNA, Mitochondrial - genetics Dysarthria - etiology Epilepsies, Partial - etiology Female Headache - etiology Humans Hypoxia, Brain - etiology Hypoxia, Brain - physiopathology Magnetic Resonance Imaging Medical sciences MELAS Syndrome - blood MELAS Syndrome - complications MELAS Syndrome - genetics MELAS Syndrome - physiopathology Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes Mutation, Missense Neurology Oxygen - metabolism Oxygen Consumption Oxygen extraction fraction Paresis - etiology Vascular diseases and vascular malformations of the nervous system |
| title | MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS |
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