Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study
Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the...
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| Veröffentlicht in: | Angiology 2013-04, Vol.64 (3), p.211-215 |
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| creator | Kitahara, Hideki Fujimoto, Yoshihide Ishikawa, Keishi Aoki, Yasuhiro Iwata, Yo Kadohira, Tadayuki Morino, Tomoki Ohkubo, Kenji Sugimoto, Kazumasa Kobayashi, Yoshio |
| description | Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10−8 mol/L (−2.4% ± 6.3% vs −4.9% ± 3.8%, P < .01) and 10−7 mol/L acetylcholine (Ach; −4.6% ± 7.6% vs −10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10−8 mol/L (−2.3% ± 4.6% vs −6.9% ± 5.0%, P < .001) and 10−7 mol/L Ach (−6.5% ± 11.4% vs −16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation. |
| doi_str_mv | 10.1177/0003319712441388 |
| format | Article |
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Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10−8 mol/L (−2.4% ± 6.3% vs −4.9% ± 3.8%, P < .01) and 10−7 mol/L acetylcholine (Ach; −4.6% ± 7.6% vs −10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10−8 mol/L (−2.3% ± 4.6% vs −6.9% ± 5.0%, P < .001) and 10−7 mol/L Ach (−6.5% ± 11.4% vs −16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/0003319712441388</identifier><identifier>PMID: 22523131</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Coronary Angiography ; Coronary Disease - physiopathology ; Coronary Disease - therapy ; Drug-Eluting Stents ; Endothelium, Vascular - physiopathology ; Female ; Humans ; Immunosuppressive Agents - administration & dosage ; Male ; Middle Aged ; Pilot Projects ; Sirolimus - administration & dosage</subject><ispartof>Angiology, 2013-04, Vol.64 (3), p.211-215</ispartof><rights>The Author(s) 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c290t-3ec9fb57c8f4deb230a927f856d2722b9a70f3e7d9eb200dea2ba4ff49523f103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0003319712441388$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0003319712441388$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22523131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitahara, Hideki</creatorcontrib><creatorcontrib>Fujimoto, Yoshihide</creatorcontrib><creatorcontrib>Ishikawa, Keishi</creatorcontrib><creatorcontrib>Aoki, Yasuhiro</creatorcontrib><creatorcontrib>Iwata, Yo</creatorcontrib><creatorcontrib>Kadohira, Tadayuki</creatorcontrib><creatorcontrib>Morino, Tomoki</creatorcontrib><creatorcontrib>Ohkubo, Kenji</creatorcontrib><creatorcontrib>Sugimoto, Kazumasa</creatorcontrib><creatorcontrib>Kobayashi, Yoshio</creatorcontrib><title>Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study</title><title>Angiology</title><addtitle>Angiology</addtitle><description>Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10−8 mol/L (−2.4% ± 6.3% vs −4.9% ± 3.8%, P < .01) and 10−7 mol/L acetylcholine (Ach; −4.6% ± 7.6% vs −10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10−8 mol/L (−2.3% ± 4.6% vs −6.9% ± 5.0%, P < .001) and 10−7 mol/L Ach (−6.5% ± 11.4% vs −16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation.</description><subject>Aged</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary Disease - therapy</subject><subject>Drug-Eluting Stents</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Sirolimus - administration & dosage</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Lw0AQxRdRbK3ePUmOXqL7lW72WEqrYkGweg6bZLamJNm6H0L_eze0ehA8DcP7zWPeQ-ia4DtChLjHGDNGpCCUc8Ly_ASNieQ4JZngp2g8yOmgj9CFc9u4ZgRPz9GI0owywsgYPb9CZb7A7hOjk0VfG_8BbaPaZBn6yjemT2bag03WjTVt0wWXLtrgm36TrD30Pnnqdq3qvRrQS3SmVevg6jgn6H25eJs_pquXh6f5bJVWVGKfMqikLjNR5ZrXUFKGlaRC59m0poLSUiqBNQNRyyhiXIOipeJacxmf1gSzCbo9-O6s-QzgfNE1roI2PgImuCIG47nkhMuI4gNaWeOcBV3sbNMpuy8ILoYKi78VxpObo3soO6h_D346i0B6AJzaQLE1wfYx7f-G36XkeLA</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Kitahara, Hideki</creator><creator>Fujimoto, Yoshihide</creator><creator>Ishikawa, Keishi</creator><creator>Aoki, Yasuhiro</creator><creator>Iwata, Yo</creator><creator>Kadohira, Tadayuki</creator><creator>Morino, Tomoki</creator><creator>Ohkubo, Kenji</creator><creator>Sugimoto, Kazumasa</creator><creator>Kobayashi, Yoshio</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation</title><author>Kitahara, Hideki ; Fujimoto, Yoshihide ; Ishikawa, Keishi ; Aoki, Yasuhiro ; Iwata, Yo ; Kadohira, Tadayuki ; Morino, Tomoki ; Ohkubo, Kenji ; Sugimoto, Kazumasa ; Kobayashi, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-3ec9fb57c8f4deb230a927f856d2722b9a70f3e7d9eb200dea2ba4ff49523f103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary Disease - therapy</topic><topic>Drug-Eluting Stents</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Sirolimus - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitahara, Hideki</creatorcontrib><creatorcontrib>Fujimoto, Yoshihide</creatorcontrib><creatorcontrib>Ishikawa, Keishi</creatorcontrib><creatorcontrib>Aoki, Yasuhiro</creatorcontrib><creatorcontrib>Iwata, Yo</creatorcontrib><creatorcontrib>Kadohira, Tadayuki</creatorcontrib><creatorcontrib>Morino, Tomoki</creatorcontrib><creatorcontrib>Ohkubo, Kenji</creatorcontrib><creatorcontrib>Sugimoto, Kazumasa</creatorcontrib><creatorcontrib>Kobayashi, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitahara, Hideki</au><au>Fujimoto, Yoshihide</au><au>Ishikawa, Keishi</au><au>Aoki, Yasuhiro</au><au>Iwata, Yo</au><au>Kadohira, Tadayuki</au><au>Morino, Tomoki</au><au>Ohkubo, Kenji</au><au>Sugimoto, Kazumasa</au><au>Kobayashi, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2013-04</date><risdate>2013</risdate><volume>64</volume><issue>3</issue><spage>211</spage><epage>215</epage><pages>211-215</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><abstract>Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10−8 mol/L (−2.4% ± 6.3% vs −4.9% ± 3.8%, P < .01) and 10−7 mol/L acetylcholine (Ach; −4.6% ± 7.6% vs −10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10−8 mol/L (−2.3% ± 4.6% vs −6.9% ± 5.0%, P < .001) and 10−7 mol/L Ach (−6.5% ± 11.4% vs −16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22523131</pmid><doi>10.1177/0003319712441388</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Coronary Angiography Coronary Disease - physiopathology Coronary Disease - therapy Drug-Eluting Stents Endothelium, Vascular - physiopathology Female Humans Immunosuppressive Agents - administration & dosage Male Middle Aged Pilot Projects Sirolimus - administration & dosage |
| title | Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study |
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