Tear nitric oxide levels in Behçet's disease
The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet's disease and to compare it with that in healthy subjects. MATERIAL AND METHODS. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations we...
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| Veröffentlicht in: | Medicina (Kaunas, Lithuania) Lithuania), 2012-01, Vol.48 (11), p.559-562 |
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| creator | İşcan, Yalçın Yiğit, Ulviye Tuğcu, Betül Çakmak Erdoğan, Mehmet Erdoğan, Derya Ars Öner, Veysi Taş, Mehmet Özyazgan, Yılmaz |
| description | The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet's disease and to compare it with that in healthy subjects. MATERIAL AND METHODS. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm. RESULTS. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups. CONCLUSION. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet's disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases. |
| doi_str_mv | 10.3390/medicina48110081 |
| format | Article |
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MATERIAL AND METHODS. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm. RESULTS. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups. CONCLUSION. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet's disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.</description><identifier>ISSN: 1648-9144</identifier><identifier>EISSN: 1648-9144</identifier><identifier>DOI: 10.3390/medicina48110081</identifier><identifier>PMID: 23455889</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adult ; Behcet Syndrome - diagnosis ; Female ; Humans ; Male ; Nitric Oxide - analysis ; Tears - chemistry</subject><ispartof>Medicina (Kaunas, Lithuania), 2012-01, Vol.48 (11), p.559-562</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-7c84830473efea39d35577474ca4ae4d488ec2b69fe373661d61b0d2c6ba27f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23455889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>İşcan, Yalçın</creatorcontrib><creatorcontrib>Yiğit, Ulviye</creatorcontrib><creatorcontrib>Tuğcu, Betül Çakmak</creatorcontrib><creatorcontrib>Erdoğan, Mehmet</creatorcontrib><creatorcontrib>Erdoğan, Derya Ars</creatorcontrib><creatorcontrib>Öner, Veysi</creatorcontrib><creatorcontrib>Taş, Mehmet</creatorcontrib><creatorcontrib>Özyazgan, Yılmaz</creatorcontrib><title>Tear nitric oxide levels in Behçet's disease</title><title>Medicina (Kaunas, Lithuania)</title><addtitle>Medicina (Kaunas)</addtitle><description>The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet's disease and to compare it with that in healthy subjects. MATERIAL AND METHODS. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm. RESULTS. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups. CONCLUSION. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet's disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.</description><subject>Adult</subject><subject>Behcet Syndrome - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nitric Oxide - analysis</subject><subject>Tears - chemistry</subject><issn>1648-9144</issn><issn>1648-9144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1OwzAUhS0EoqWwM6FssAR8c29iZ4SKP6kSS5kjx74RRmlS7BTBE_EgvBhFLQgxnSOdn-ET4hjkOWIpLxbsvPWdIQ0gpYYdMYaCdFoC0e4fPxIHMT5LiVmusn0xypDyXOtyLNI5m5B0fgjeJv2bd5y0_MptTHyXXPHT5wcPpzFxPrKJfCj2GtNGPtrqRDzeXM-nd-ns4fZ-ejlLLRIMqbKaNEpSyA0bLB3muVKkyBoyTI60ZpvVRdkwKiwKcAXU0mW2qE2mGoUTcbb5XYb-ZcVxqBY-Wm5b03G_ihUgkAKCLF9X5aZqQx9j4KZaBr8w4b0CWX1Dqv5DWk9Otu-reh3-Dn6o4Bew62MN</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>İşcan, Yalçın</creator><creator>Yiğit, Ulviye</creator><creator>Tuğcu, Betül Çakmak</creator><creator>Erdoğan, Mehmet</creator><creator>Erdoğan, Derya Ars</creator><creator>Öner, Veysi</creator><creator>Taş, Mehmet</creator><creator>Özyazgan, Yılmaz</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Tear nitric oxide levels in Behçet's disease</title><author>İşcan, Yalçın ; Yiğit, Ulviye ; Tuğcu, Betül Çakmak ; Erdoğan, Mehmet ; Erdoğan, Derya Ars ; Öner, Veysi ; Taş, Mehmet ; Özyazgan, Yılmaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-7c84830473efea39d35577474ca4ae4d488ec2b69fe373661d61b0d2c6ba27f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Behcet Syndrome - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nitric Oxide - analysis</topic><topic>Tears - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>İşcan, Yalçın</creatorcontrib><creatorcontrib>Yiğit, Ulviye</creatorcontrib><creatorcontrib>Tuğcu, Betül Çakmak</creatorcontrib><creatorcontrib>Erdoğan, Mehmet</creatorcontrib><creatorcontrib>Erdoğan, Derya Ars</creatorcontrib><creatorcontrib>Öner, Veysi</creatorcontrib><creatorcontrib>Taş, Mehmet</creatorcontrib><creatorcontrib>Özyazgan, Yılmaz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicina (Kaunas, Lithuania)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>İşcan, Yalçın</au><au>Yiğit, Ulviye</au><au>Tuğcu, Betül Çakmak</au><au>Erdoğan, Mehmet</au><au>Erdoğan, Derya Ars</au><au>Öner, Veysi</au><au>Taş, Mehmet</au><au>Özyazgan, Yılmaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tear nitric oxide levels in Behçet's disease</atitle><jtitle>Medicina (Kaunas, Lithuania)</jtitle><addtitle>Medicina (Kaunas)</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>48</volume><issue>11</issue><spage>559</spage><epage>562</epage><pages>559-562</pages><issn>1648-9144</issn><eissn>1648-9144</eissn><abstract>The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet's disease and to compare it with that in healthy subjects. MATERIAL AND METHODS. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm. RESULTS. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups. CONCLUSION. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet's disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.</abstract><cop>Switzerland</cop><pmid>23455889</pmid><doi>10.3390/medicina48110081</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Behcet Syndrome - diagnosis Female Humans Male Nitric Oxide - analysis Tears - chemistry |
| title | Tear nitric oxide levels in Behçet's disease |
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