Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity and cell survival signals, whereas NMDARs residing in the neuronal membrane outside synapses trigger neurodegeneration. At present, it is unclear how these opposing signals are transduced to and discriminated b...

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Veröffentlicht in:	Cell 2013-02, Vol.152 (5), p.1119-1133
Hauptverfasser:	Karpova, Anna, Mikhaylova, Marina, Bera, Sujoy, Bär, Julia, Reddy, Pasham Parameshwar, Behnisch, Thomas, Rankovic, Vladan, Spilker, Christina, Bethge, Philipp, Sahin, Jale, Kaushik, Rahul, Zuschratter, Werner, Kähne, Thilo, Naumann, Michael, Gundelfinger, Eckart D., Kreutz, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell death Cell Nucleus - metabolism Cell Survival cell viability Cells, Cultured Cyclic AMP Response Element-Binding Protein - metabolism dephosphorylation Gene Expression Regulation Hippocampus - cytology Hippocampus - metabolism Intermediate Filament Proteins - metabolism Long-Term Potentiation Long-Term Synaptic Depression MAP Kinase Signaling System Mice mitogen-activated protein kinase Nerve Tissue Proteins - metabolism neurodegenerative diseases Neurons - cytology Neurons - metabolism Phosphoric Monoester Hydrolases - metabolism Phosphorylation plasticity Rats Receptors, N-Methyl-D-Aspartate - metabolism signals Synapses - metabolism
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