Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice

Abstract Introduction Aldehyde dehydrogenase 2 (ALDH2) degrades acetaldehyde produced by the metabolism of alcohol. The inactive ALDH2 phenotype is prevalent in East Asians, and an association between this ALDH2 polymorphism and osteoporosis has been reported. In our previous study, we found that al...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2013-04, Vol.53 (2), p.358-368
Hauptverfasser:	Tsuchiya, Takuto, Sakai, Akinori, Menuki, Kunitaka, Mori, Toshiharu, Takeuchi, Yoshinori, Kanoh, Shinkichi, Utsunomiya, Hajime, Murai, Teppei, Isse, Toyohi, Kawamoto, Toshihiro, Nakamura, Toshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Aldehyde dehydrogenase 2 (ALDH2) Aldehyde Dehydrogenase, Mitochondrial Animals Biological and medical sciences Bone Density - genetics Bone Density - physiology Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Cortical bone Diaphyses - metabolism Female Femur Femur - diagnostic imaging Femur - metabolism Fundamental and applied biological sciences. Psychology Histomorphometry Investigative techniques, diagnostic techniques (general aspects) Male Mechanical loading Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Orthopedics Osteoarticular system. Muscles pQCT Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiography Vertebrates: anatomy and physiology, studies on body, several organs or systems
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