Atrial stretch delays gastric emptying of liquids in awake rats
We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Anesthetized male rats receive...
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Veröffentlicht in: | Life sciences (1973) 2013-03, Vol.92 (10), p.569-575 |
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creator | Palheta, R.C. Silva, M.T.B. Barbosa, H.L.G. Pinheiro, A.D.N. Cardoso, K.V.V. Graça, J.R.V. Magalhães, P.J.C. Oliveira, R.B. Santos, A.A. |
description | We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms.
Anesthetized male rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70μl saline for 5min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30min later.
Heart rate and CVP values were transiently increased by 50 or 70μl AS but not 30μl AS, whereas gastric emptying was slower after 30, 50, or 70μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it.
Atrial stretch inhibited the gastric emptying of liquid via non-adrenergic and non-cholinergic pathways that activate nitric oxide-K+ATP channels. |
doi_str_mv | 10.1016/j.lfs.2013.01.016 |
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Anesthetized male rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70μl saline for 5min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30min later.
Heart rate and CVP values were transiently increased by 50 or 70μl AS but not 30μl AS, whereas gastric emptying was slower after 30, 50, or 70μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it.
Atrial stretch inhibited the gastric emptying of liquid via non-adrenergic and non-cholinergic pathways that activate nitric oxide-K+ATP channels.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2013.01.016</identifier><identifier>PMID: 23352973</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Atrial Function, Right - physiology ; Atropine - pharmacology ; Balloon Occlusion - methods ; Blood Pressure ; Capsaicin - pharmacology ; Cardiac Catheterization - methods ; Cardiac distention ; Catheterization - methods ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; Gastric motility ; Gastrointestinal Transit - physiology ; Gastrostomy - methods ; Glyburide - pharmacology ; Guanethidine - pharmacology ; Heart Atria - surgery ; Heart Rate ; Hexamethonium - pharmacology ; Hypovolemia - physiopathology ; Male ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric oxide ; Nitric Oxide - blood ; Non-adrenergic and non-cholinergic nerves ; Ondansetron - pharmacology ; Rats</subject><ispartof>Life sciences (1973), 2013-03, Vol.92 (10), p.569-575</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-2b5159c284d8bd36a3f0eabd30d57dc72123e7c354099527085ba9659889e42c3</citedby><cites>FETCH-LOGICAL-c396t-2b5159c284d8bd36a3f0eabd30d57dc72123e7c354099527085ba9659889e42c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2013.01.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23352973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palheta, R.C.</creatorcontrib><creatorcontrib>Silva, M.T.B.</creatorcontrib><creatorcontrib>Barbosa, H.L.G.</creatorcontrib><creatorcontrib>Pinheiro, A.D.N.</creatorcontrib><creatorcontrib>Cardoso, K.V.V.</creatorcontrib><creatorcontrib>Graça, J.R.V.</creatorcontrib><creatorcontrib>Magalhães, P.J.C.</creatorcontrib><creatorcontrib>Oliveira, R.B.</creatorcontrib><creatorcontrib>Santos, A.A.</creatorcontrib><title>Atrial stretch delays gastric emptying of liquids in awake rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms.
Anesthetized male rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70μl saline for 5min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30min later.
Heart rate and CVP values were transiently increased by 50 or 70μl AS but not 30μl AS, whereas gastric emptying was slower after 30, 50, or 70μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it.
Atrial stretch inhibited the gastric emptying of liquid via non-adrenergic and non-cholinergic pathways that activate nitric oxide-K+ATP channels.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Atrial Function, Right - physiology</subject><subject>Atropine - pharmacology</subject><subject>Balloon Occlusion - methods</subject><subject>Blood Pressure</subject><subject>Capsaicin - pharmacology</subject><subject>Cardiac Catheterization - methods</subject><subject>Cardiac distention</subject><subject>Catheterization - methods</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Emptying - physiology</subject><subject>Gastric motility</subject><subject>Gastrointestinal Transit - physiology</subject><subject>Gastrostomy - methods</subject><subject>Glyburide - pharmacology</subject><subject>Guanethidine - pharmacology</subject><subject>Heart Atria - surgery</subject><subject>Heart Rate</subject><subject>Hexamethonium - pharmacology</subject><subject>Hypovolemia - physiopathology</subject><subject>Male</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Non-adrenergic and non-cholinergic nerves</subject><subject>Ondansetron - pharmacology</subject><subject>Rats</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMoWqsfwIvk6GXrJNlsNngQKf6Dghc9h2wyq6nbbk22Sr-9kVaPwoMZhvcezI-QMwYTBqy6nE-6Nk04MDEBllXtkRGrlS6gEmyfjAB4WQgO8ogcpzQHACmVOCRHXAjJtRIjcn0zxGA7moaIg3ujHju7SfTV5kNwFBerYROWr7RvaRc-1sEnGpbUftl3pNEO6YQctLZLeLqbY_Jyd_s8fShmT_eP05tZ4YSuhoI3kknteF36uvGisqIFtHkDL5V3ijMuUDkhS9BacgW1bKyupK5rjSV3Ykwutr2r2H-sMQ1mEZLDrrNL7NfJMMFKBarUkK1sa3WxTylia1YxLGzcGAbmh5uZm8zN_HAzwLKqnDnf1a-bBfq_xC-obLjaGjA_-RkwmuQCLh36ENENxvfhn_pvI8R8Yg</recordid><startdate>20130321</startdate><enddate>20130321</enddate><creator>Palheta, R.C.</creator><creator>Silva, M.T.B.</creator><creator>Barbosa, H.L.G.</creator><creator>Pinheiro, A.D.N.</creator><creator>Cardoso, K.V.V.</creator><creator>Graça, J.R.V.</creator><creator>Magalhães, P.J.C.</creator><creator>Oliveira, R.B.</creator><creator>Santos, A.A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130321</creationdate><title>Atrial stretch delays gastric emptying of liquids in awake rats</title><author>Palheta, R.C. ; Silva, M.T.B. ; Barbosa, H.L.G. ; Pinheiro, A.D.N. ; Cardoso, K.V.V. ; Graça, J.R.V. ; Magalhães, P.J.C. ; Oliveira, R.B. ; Santos, A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-2b5159c284d8bd36a3f0eabd30d57dc72123e7c354099527085ba9659889e42c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Atrial Function, Right - physiology</topic><topic>Atropine - pharmacology</topic><topic>Balloon Occlusion - methods</topic><topic>Blood Pressure</topic><topic>Capsaicin - pharmacology</topic><topic>Cardiac Catheterization - methods</topic><topic>Cardiac distention</topic><topic>Catheterization - methods</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastric Emptying - physiology</topic><topic>Gastric motility</topic><topic>Gastrointestinal Transit - physiology</topic><topic>Gastrostomy - methods</topic><topic>Glyburide - pharmacology</topic><topic>Guanethidine - pharmacology</topic><topic>Heart Atria - surgery</topic><topic>Heart Rate</topic><topic>Hexamethonium - pharmacology</topic><topic>Hypovolemia - physiopathology</topic><topic>Male</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Non-adrenergic and non-cholinergic nerves</topic><topic>Ondansetron - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palheta, R.C.</creatorcontrib><creatorcontrib>Silva, M.T.B.</creatorcontrib><creatorcontrib>Barbosa, H.L.G.</creatorcontrib><creatorcontrib>Pinheiro, A.D.N.</creatorcontrib><creatorcontrib>Cardoso, K.V.V.</creatorcontrib><creatorcontrib>Graça, J.R.V.</creatorcontrib><creatorcontrib>Magalhães, P.J.C.</creatorcontrib><creatorcontrib>Oliveira, R.B.</creatorcontrib><creatorcontrib>Santos, A.A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palheta, R.C.</au><au>Silva, M.T.B.</au><au>Barbosa, H.L.G.</au><au>Pinheiro, A.D.N.</au><au>Cardoso, K.V.V.</au><au>Graça, J.R.V.</au><au>Magalhães, P.J.C.</au><au>Oliveira, R.B.</au><au>Santos, A.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial stretch delays gastric emptying of liquids in awake rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2013-03-21</date><risdate>2013</risdate><volume>92</volume><issue>10</issue><spage>569</spage><epage>575</epage><pages>569-575</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms.
Anesthetized male rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70μl saline for 5min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30min later.
Heart rate and CVP values were transiently increased by 50 or 70μl AS but not 30μl AS, whereas gastric emptying was slower after 30, 50, or 70μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it.
Atrial stretch inhibited the gastric emptying of liquid via non-adrenergic and non-cholinergic pathways that activate nitric oxide-K+ATP channels.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23352973</pmid><doi>10.1016/j.lfs.2013.01.016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Analysis of Variance Animals Atrial Function, Right - physiology Atropine - pharmacology Balloon Occlusion - methods Blood Pressure Capsaicin - pharmacology Cardiac Catheterization - methods Cardiac distention Catheterization - methods Gastric Emptying - drug effects Gastric Emptying - physiology Gastric motility Gastrointestinal Transit - physiology Gastrostomy - methods Glyburide - pharmacology Guanethidine - pharmacology Heart Atria - surgery Heart Rate Hexamethonium - pharmacology Hypovolemia - physiopathology Male NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - blood Non-adrenergic and non-cholinergic nerves Ondansetron - pharmacology Rats |
title | Atrial stretch delays gastric emptying of liquids in awake rats |
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