High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome
In this trial, high-frequency oscillatory ventilation was compared with conventional ventilation with a lung-protective protocol. When the study was stopped early, hospital mortality was 47% with HFOV versus 35% with the control ventilation strategy. The acute respiratory distress syndrome (ARDS) is...
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| Veröffentlicht in: | The New England journal of medicine 2013-02, Vol.368 (9), p.795-805 |
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| creator | Ferguson, Niall D Cook, Deborah J Guyatt, Gordon H Mehta, Sangeeta Hand, Lori Austin, Peggy Zhou, Qi Matte, Andrea Walter, Stephen D Lamontagne, Francois Granton, John T Arabi, Yaseen M Arroliga, Alejandro C Stewart, Thomas E Slutsky, Arthur S Meade, Maureen O |
| description | In this trial, high-frequency oscillatory ventilation was compared with conventional ventilation with a lung-protective protocol. When the study was stopped early, hospital mortality was 47% with HFOV versus 35% with the control ventilation strategy.
The acute respiratory distress syndrome (ARDS) is a common complication of critical illness.
1
,
2
Mortality is high, and survivors often have long-term complications.
3
,
4
Although mechanical ventilation is life-sustaining for patients with ARDS, it can perpetuate lung injury. Basic research suggests that repetitive overstretching or collapse of lung units with each respiratory cycle can generate local and systemic inflammation, contributing to multiorgan failure and death.
5
Consistent with these findings are data from clinical trials that support the use of smaller tidal volumes (6 vs. 12 ml per kilogram of predicted body weight)
6
and higher levels of positive end-expiratory pressure (PEEP). . . . |
| doi_str_mv | 10.1056/NEJMoa1215554 |
| format | Article |
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The acute respiratory distress syndrome (ARDS) is a common complication of critical illness.
1
,
2
Mortality is high, and survivors often have long-term complications.
3
,
4
Although mechanical ventilation is life-sustaining for patients with ARDS, it can perpetuate lung injury. Basic research suggests that repetitive overstretching or collapse of lung units with each respiratory cycle can generate local and systemic inflammation, contributing to multiorgan failure and death.
5
Consistent with these findings are data from clinical trials that support the use of smaller tidal volumes (6 vs. 12 ml per kilogram of predicted body weight)
6
and higher levels of positive end-expiratory pressure (PEEP). . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1215554</identifier><identifier>PMID: 23339639</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Clinical trials ; Data processing ; Female ; General aspects ; High-Frequency Ventilation ; Hospital Mortality ; Humans ; Hypnotics and Sedatives - administration & dosage ; Hypoxemia ; Hypoxia - etiology ; Intensive care units ; Lungs ; Male ; Mechanical ventilation ; Medical sciences ; Midazolam ; Midazolam - administration & dosage ; Middle Aged ; Mortality ; Neuromuscular system ; Oxygenation ; Positive-Pressure Respiration ; Pressure ; Respiratory diseases ; Respiratory distress syndrome ; Respiratory Distress Syndrome, Adult - complications ; Respiratory Distress Syndrome, Adult - mortality ; Respiratory Distress Syndrome, Adult - therapy ; Respiratory therapy ; Survival Analysis ; Treatment Failure ; Vasoactive agents</subject><ispartof>The New England journal of medicine, 2013-02, Vol.368 (9), p.795-805</ispartof><rights>Copyright © 2013 Massachusetts Medical Society. All rights reserved.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-e8899e1c424938cfcf3361ab31dce812a75a1bab11477f9ba09559394f420eb03</citedby><cites>FETCH-LOGICAL-c486t-e8899e1c424938cfcf3361ab31dce812a75a1bab11477f9ba09559394f420eb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1215554$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1215554$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27040418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23339639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferguson, Niall D</creatorcontrib><creatorcontrib>Cook, Deborah J</creatorcontrib><creatorcontrib>Guyatt, Gordon H</creatorcontrib><creatorcontrib>Mehta, Sangeeta</creatorcontrib><creatorcontrib>Hand, Lori</creatorcontrib><creatorcontrib>Austin, Peggy</creatorcontrib><creatorcontrib>Zhou, Qi</creatorcontrib><creatorcontrib>Matte, Andrea</creatorcontrib><creatorcontrib>Walter, Stephen D</creatorcontrib><creatorcontrib>Lamontagne, Francois</creatorcontrib><creatorcontrib>Granton, John T</creatorcontrib><creatorcontrib>Arabi, Yaseen M</creatorcontrib><creatorcontrib>Arroliga, Alejandro C</creatorcontrib><creatorcontrib>Stewart, Thomas E</creatorcontrib><creatorcontrib>Slutsky, Arthur S</creatorcontrib><creatorcontrib>Meade, Maureen O</creatorcontrib><creatorcontrib>OSCILLATE Trial Investigators</creatorcontrib><creatorcontrib>Canadian Critical Care Trials Group</creatorcontrib><title>High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this trial, high-frequency oscillatory ventilation was compared with conventional ventilation with a lung-protective protocol. When the study was stopped early, hospital mortality was 47% with HFOV versus 35% with the control ventilation strategy.
The acute respiratory distress syndrome (ARDS) is a common complication of critical illness.
1
,
2
Mortality is high, and survivors often have long-term complications.
3
,
4
Although mechanical ventilation is life-sustaining for patients with ARDS, it can perpetuate lung injury. Basic research suggests that repetitive overstretching or collapse of lung units with each respiratory cycle can generate local and systemic inflammation, contributing to multiorgan failure and death.
5
Consistent with these findings are data from clinical trials that support the use of smaller tidal volumes (6 vs. 12 ml per kilogram of predicted body weight)
6
and higher levels of positive end-expiratory pressure (PEEP). . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Data processing</subject><subject>Female</subject><subject>General aspects</subject><subject>High-Frequency Ventilation</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Hypoxemia</subject><subject>Hypoxia - etiology</subject><subject>Intensive care units</subject><subject>Lungs</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical sciences</subject><subject>Midazolam</subject><subject>Midazolam - administration & dosage</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neuromuscular system</subject><subject>Oxygenation</subject><subject>Positive-Pressure Respiration</subject><subject>Pressure</subject><subject>Respiratory diseases</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Adult - complications</subject><subject>Respiratory Distress Syndrome, Adult - mortality</subject><subject>Respiratory Distress Syndrome, Adult - therapy</subject><subject>Respiratory therapy</subject><subject>Survival Analysis</subject><subject>Treatment Failure</subject><subject>Vasoactive agents</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10M9LwzAUB_AgipvTo1cpiOClmtckbXMccz-U6cAf55JmqWa0zUzaQ_97MzYdCr7Lu3x478sXoXPAN4BZfPs0fng0AiJgjNED1AdGSEgpjg9RH-MoDWnCSQ-dOLfCfoDyY9SLCCE8JryPpjP9_hFOrPpsVS27YOGkLkvRaFMHug7GwpZdMJRto4Jn5dbaisbYLrjTrrHKueClq5fWVOoUHRWidOpstwfobTJ-Hc3C-WJ6PxrOQ0nTuAlVmnKuQNKIcpLKQhaExCByAkupUohEwgTkIgegSVLwXGDOGCecFjTCKsdkgK63d9fW-MiuySrtpPKRa2ValwEBSijGlHl6-YeuTGtrn26jiO8p9XaAwq2S1jhnVZGtra6E7TLA2abh7FfD3l_srrZ5pZY_-rtSD652QDgpysKKWmq3dwmmmEK6d1Xlslqtqn8efgHwYY0Q</recordid><startdate>20130228</startdate><enddate>20130228</enddate><creator>Ferguson, Niall D</creator><creator>Cook, Deborah J</creator><creator>Guyatt, Gordon H</creator><creator>Mehta, Sangeeta</creator><creator>Hand, Lori</creator><creator>Austin, Peggy</creator><creator>Zhou, Qi</creator><creator>Matte, Andrea</creator><creator>Walter, Stephen D</creator><creator>Lamontagne, Francois</creator><creator>Granton, John T</creator><creator>Arabi, Yaseen M</creator><creator>Arroliga, Alejandro C</creator><creator>Stewart, Thomas E</creator><creator>Slutsky, Arthur S</creator><creator>Meade, Maureen O</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130228</creationdate><title>High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome</title><author>Ferguson, Niall D ; Cook, Deborah J ; Guyatt, Gordon H ; Mehta, Sangeeta ; Hand, Lori ; Austin, Peggy ; Zhou, Qi ; Matte, Andrea ; Walter, Stephen D ; Lamontagne, Francois ; Granton, John T ; Arabi, Yaseen M ; Arroliga, Alejandro C ; Stewart, Thomas E ; Slutsky, Arthur S ; Meade, Maureen O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-e8899e1c424938cfcf3361ab31dce812a75a1bab11477f9ba09559394f420eb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Clinical trials</topic><topic>Data processing</topic><topic>Female</topic><topic>General aspects</topic><topic>High-Frequency Ventilation</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Hypoxemia</topic><topic>Hypoxia - etiology</topic><topic>Intensive care units</topic><topic>Lungs</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical sciences</topic><topic>Midazolam</topic><topic>Midazolam - administration & dosage</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neuromuscular system</topic><topic>Oxygenation</topic><topic>Positive-Pressure Respiration</topic><topic>Pressure</topic><topic>Respiratory diseases</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome, Adult - complications</topic><topic>Respiratory Distress Syndrome, Adult - mortality</topic><topic>Respiratory Distress Syndrome, Adult - therapy</topic><topic>Respiratory therapy</topic><topic>Survival Analysis</topic><topic>Treatment Failure</topic><topic>Vasoactive agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferguson, Niall D</creatorcontrib><creatorcontrib>Cook, Deborah J</creatorcontrib><creatorcontrib>Guyatt, Gordon H</creatorcontrib><creatorcontrib>Mehta, Sangeeta</creatorcontrib><creatorcontrib>Hand, Lori</creatorcontrib><creatorcontrib>Austin, Peggy</creatorcontrib><creatorcontrib>Zhou, Qi</creatorcontrib><creatorcontrib>Matte, Andrea</creatorcontrib><creatorcontrib>Walter, Stephen D</creatorcontrib><creatorcontrib>Lamontagne, Francois</creatorcontrib><creatorcontrib>Granton, John T</creatorcontrib><creatorcontrib>Arabi, Yaseen M</creatorcontrib><creatorcontrib>Arroliga, Alejandro C</creatorcontrib><creatorcontrib>Stewart, Thomas E</creatorcontrib><creatorcontrib>Slutsky, Arthur S</creatorcontrib><creatorcontrib>Meade, Maureen O</creatorcontrib><creatorcontrib>OSCILLATE Trial Investigators</creatorcontrib><creatorcontrib>Canadian Critical Care Trials Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferguson, Niall D</au><au>Cook, Deborah J</au><au>Guyatt, Gordon H</au><au>Mehta, Sangeeta</au><au>Hand, Lori</au><au>Austin, Peggy</au><au>Zhou, Qi</au><au>Matte, Andrea</au><au>Walter, Stephen D</au><au>Lamontagne, Francois</au><au>Granton, John T</au><au>Arabi, Yaseen M</au><au>Arroliga, Alejandro C</au><au>Stewart, Thomas E</au><au>Slutsky, Arthur S</au><au>Meade, Maureen O</au><aucorp>OSCILLATE Trial Investigators</aucorp><aucorp>Canadian Critical Care Trials Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2013-02-28</date><risdate>2013</risdate><volume>368</volume><issue>9</issue><spage>795</spage><epage>805</epage><pages>795-805</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this trial, high-frequency oscillatory ventilation was compared with conventional ventilation with a lung-protective protocol. When the study was stopped early, hospital mortality was 47% with HFOV versus 35% with the control ventilation strategy.
The acute respiratory distress syndrome (ARDS) is a common complication of critical illness.
1
,
2
Mortality is high, and survivors often have long-term complications.
3
,
4
Although mechanical ventilation is life-sustaining for patients with ARDS, it can perpetuate lung injury. Basic research suggests that repetitive overstretching or collapse of lung units with each respiratory cycle can generate local and systemic inflammation, contributing to multiorgan failure and death.
5
Consistent with these findings are data from clinical trials that support the use of smaller tidal volumes (6 vs. 12 ml per kilogram of predicted body weight)
6
and higher levels of positive end-expiratory pressure (PEEP). . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>23339639</pmid><doi>10.1056/NEJMoa1215554</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2013-02, Vol.368 (9), p.795-805 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Adult Aged Biological and medical sciences Clinical trials Data processing Female General aspects High-Frequency Ventilation Hospital Mortality Humans Hypnotics and Sedatives - administration & dosage Hypoxemia Hypoxia - etiology Intensive care units Lungs Male Mechanical ventilation Medical sciences Midazolam Midazolam - administration & dosage Middle Aged Mortality Neuromuscular system Oxygenation Positive-Pressure Respiration Pressure Respiratory diseases Respiratory distress syndrome Respiratory Distress Syndrome, Adult - complications Respiratory Distress Syndrome, Adult - mortality Respiratory Distress Syndrome, Adult - therapy Respiratory therapy Survival Analysis Treatment Failure Vasoactive agents |
| title | High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome |
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