Which patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factors

Background Patients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Material and methods Charts of 140 patients w...

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Veröffentlicht in:Supportive care in cancer 2013-04, Vol.21 (4), p.1131-1135
Hauptverfasser: Abali, Hüseyin, Sezer, Ahmet, Oğuzkurt, Levent, Gürel, Kamil, Özkan, Uğur, Beşen, Ali Ayberk, Sümbül, Ahmet Taner, Köse, Fatih, Dişel, Umut, Muallaoğlu, Sadık, Özyılkan, Özgür
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container_end_page 1135
container_issue 4
container_start_page 1131
container_title Supportive care in cancer
container_volume 21
creator Abali, Hüseyin
Sezer, Ahmet
Oğuzkurt, Levent
Gürel, Kamil
Özkan, Uğur
Beşen, Ali Ayberk
Sümbül, Ahmet Taner
Köse, Fatih
Dişel, Umut
Muallaoğlu, Sadık
Özyılkan, Özgür
description Background Patients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Material and methods Charts of 140 patients with advanced cancer who underwent biliary stenting were retrospectively analyzed. Their median age was 63.5 years. Of these patients, 73 (52.1 %) were male, 32 (22.9 %) had ECOG PS 1 and 81 (57.9 %) had PS 2. The most frequent cancer types were cholangiocellular cancer (64, 45.7 %) and pancreatic cancer (36, 25.7 %). Results Median overall survival (OS) was 141 (95 % CI, 100.7-185.3) days. Female patients lived longer (161.0 vs. 124.0 days) ( p  = 0.036). Those patients with colorectal cancer lived the longest (667.0 days), followed by cholangiocellular (211.0 days), and gastric cancers (106.0 days) ( p  = 0.004). The distribution of primary diagnosis differed significantly between sexes: cholangiocellular cancer was present in 22 (30.1 %) out of 73 men and 42(62.7 %) out of 67 women (chi-square p  
doi_str_mv 10.1007/s00520-012-1636-z
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An analysis of prognostic factors</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Abali, Hüseyin ; Sezer, Ahmet ; Oğuzkurt, Levent ; Gürel, Kamil ; Özkan, Uğur ; Beşen, Ali Ayberk ; Sümbül, Ahmet Taner ; Köse, Fatih ; Dişel, Umut ; Muallaoğlu, Sadık ; Özyılkan, Özgür</creator><creatorcontrib>Abali, Hüseyin ; Sezer, Ahmet ; Oğuzkurt, Levent ; Gürel, Kamil ; Özkan, Uğur ; Beşen, Ali Ayberk ; Sümbül, Ahmet Taner ; Köse, Fatih ; Dişel, Umut ; Muallaoğlu, Sadık ; Özyılkan, Özgür</creatorcontrib><description>Background Patients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Material and methods Charts of 140 patients with advanced cancer who underwent biliary stenting were retrospectively analyzed. Their median age was 63.5 years. Of these patients, 73 (52.1 %) were male, 32 (22.9 %) had ECOG PS 1 and 81 (57.9 %) had PS 2. The most frequent cancer types were cholangiocellular cancer (64, 45.7 %) and pancreatic cancer (36, 25.7 %). Results Median overall survival (OS) was 141 (95 % CI, 100.7-185.3) days. Female patients lived longer (161.0 vs. 124.0 days) ( p  = 0.036). Those patients with colorectal cancer lived the longest (667.0 days), followed by cholangiocellular (211.0 days), and gastric cancers (106.0 days) ( p  = 0.004). The distribution of primary diagnosis differed significantly between sexes: cholangiocellular cancer was present in 22 (30.1 %) out of 73 men and 42(62.7 %) out of 67 women (chi-square p  &lt; 0.001). There was a trend for longer overall survival if ALT ( p  = 0.08) and AST ( p  = 0.06) were normalized after stent insertion. Of the 137 patients, 63 (45.5 %) did not experience any complication. In 74 patients with complications, there were 39 (28.5 %) episodes of cholangitic infections and 35 (25.5 %) biliary obstructions. In three patients, we could not find data on infections. Conclusion Underlying malignancy, hence the natural biology and the therapeutic expectations are probably the most important factors which must be considered during decision-making.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-012-1636-z</identifier><identifier>PMID: 23132146</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Cancer ; Cancer patients ; Care and treatment ; Chemotherapy ; Colorectal cancer ; Confidence Intervals ; Female ; Gastric cancer ; Humans ; Jaundice, Obstructive - etiology ; Jaundice, Obstructive - surgery ; Male ; Medical Audit ; Medical prognosis ; Medicine ; Medicine &amp; Public Health ; Metastasis ; Middle Aged ; Neoplasms - complications ; Neoplasms - pathology ; Nursing ; Nursing Research ; Oncology ; Original Article ; Outcome Assessment (Health Care) - methods ; Pain Medicine ; Pancreatic cancer ; Patients ; Prognosis ; Rehabilitation Medicine ; Retrospective Studies ; Sexes ; Stent (Surgery) ; Stents ; Survival Analysis</subject><ispartof>Supportive care in cancer, 2013-04, Vol.21 (4), p.1131-1135</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-f0ad247d8a4c923e445a52fe44f185ebdf256a81ec14f185dd5e28a40628c6fd3</citedby><cites>FETCH-LOGICAL-c439t-f0ad247d8a4c923e445a52fe44f185ebdf256a81ec14f185dd5e28a40628c6fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-012-1636-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-012-1636-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23132146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abali, Hüseyin</creatorcontrib><creatorcontrib>Sezer, Ahmet</creatorcontrib><creatorcontrib>Oğuzkurt, Levent</creatorcontrib><creatorcontrib>Gürel, Kamil</creatorcontrib><creatorcontrib>Özkan, Uğur</creatorcontrib><creatorcontrib>Beşen, Ali Ayberk</creatorcontrib><creatorcontrib>Sümbül, Ahmet Taner</creatorcontrib><creatorcontrib>Köse, Fatih</creatorcontrib><creatorcontrib>Dişel, Umut</creatorcontrib><creatorcontrib>Muallaoğlu, Sadık</creatorcontrib><creatorcontrib>Özyılkan, Özgür</creatorcontrib><title>Which patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factors</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Background Patients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Material and methods Charts of 140 patients with advanced cancer who underwent biliary stenting were retrospectively analyzed. Their median age was 63.5 years. Of these patients, 73 (52.1 %) were male, 32 (22.9 %) had ECOG PS 1 and 81 (57.9 %) had PS 2. The most frequent cancer types were cholangiocellular cancer (64, 45.7 %) and pancreatic cancer (36, 25.7 %). Results Median overall survival (OS) was 141 (95 % CI, 100.7-185.3) days. Female patients lived longer (161.0 vs. 124.0 days) ( p  = 0.036). Those patients with colorectal cancer lived the longest (667.0 days), followed by cholangiocellular (211.0 days), and gastric cancers (106.0 days) ( p  = 0.004). The distribution of primary diagnosis differed significantly between sexes: cholangiocellular cancer was present in 22 (30.1 %) out of 73 men and 42(62.7 %) out of 67 women (chi-square p  &lt; 0.001). There was a trend for longer overall survival if ALT ( p  = 0.08) and AST ( p  = 0.06) were normalized after stent insertion. Of the 137 patients, 63 (45.5 %) did not experience any complication. In 74 patients with complications, there were 39 (28.5 %) episodes of cholangitic infections and 35 (25.5 %) biliary obstructions. In three patients, we could not find data on infections. 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An analysis of prognostic factors</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>21</volume><issue>4</issue><spage>1131</spage><epage>1135</epage><pages>1131-1135</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Background Patients with advanced cancer may present with obstructive jaundice. Biliary stenting is the treatment of choice. However, which patients benefit most is not well-defined, yet. Our aim was to delineate the clinical factors affecting prognosis. Material and methods Charts of 140 patients with advanced cancer who underwent biliary stenting were retrospectively analyzed. Their median age was 63.5 years. Of these patients, 73 (52.1 %) were male, 32 (22.9 %) had ECOG PS 1 and 81 (57.9 %) had PS 2. The most frequent cancer types were cholangiocellular cancer (64, 45.7 %) and pancreatic cancer (36, 25.7 %). Results Median overall survival (OS) was 141 (95 % CI, 100.7-185.3) days. Female patients lived longer (161.0 vs. 124.0 days) ( p  = 0.036). Those patients with colorectal cancer lived the longest (667.0 days), followed by cholangiocellular (211.0 days), and gastric cancers (106.0 days) ( p  = 0.004). The distribution of primary diagnosis differed significantly between sexes: cholangiocellular cancer was present in 22 (30.1 %) out of 73 men and 42(62.7 %) out of 67 women (chi-square p  &lt; 0.001). There was a trend for longer overall survival if ALT ( p  = 0.08) and AST ( p  = 0.06) were normalized after stent insertion. Of the 137 patients, 63 (45.5 %) did not experience any complication. In 74 patients with complications, there were 39 (28.5 %) episodes of cholangitic infections and 35 (25.5 %) biliary obstructions. In three patients, we could not find data on infections. Conclusion Underlying malignancy, hence the natural biology and the therapeutic expectations are probably the most important factors which must be considered during decision-making.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23132146</pmid><doi>10.1007/s00520-012-1636-z</doi><tpages>5</tpages></addata></record>
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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Adult
Aged
Aged, 80 and over
Analysis
Cancer
Cancer patients
Care and treatment
Chemotherapy
Colorectal cancer
Confidence Intervals
Female
Gastric cancer
Humans
Jaundice, Obstructive - etiology
Jaundice, Obstructive - surgery
Male
Medical Audit
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neoplasms - complications
Neoplasms - pathology
Nursing
Nursing Research
Oncology
Original Article
Outcome Assessment (Health Care) - methods
Pain Medicine
Pancreatic cancer
Patients
Prognosis
Rehabilitation Medicine
Retrospective Studies
Sexes
Stent (Surgery)
Stents
Survival Analysis
title Which patients with advanced cancer and biliary obstruction benefit from biliary stenting most? An analysis of prognostic factors
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