LC/MS/MS of Steroids Having Vicinal Diol as Electrospray-Active Boronates

A derivatization procedure with (3-dimethylaminophenyl)dihydroxyborane (DAPB) was introduced to enhance the detectability of steroids having a vicinal diol in LC/electrospray ionization (ESI)-MS/MS. DAPB reacted with the vicinal diol on the steroids [4β-hydroxycholesterol (4-HCh), pregnanetriol (PT)...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2013/03/01, Vol.61(3), pp.326-332
Hauptverfasser:	Higashi, Tatsuya, Kawasaki, Katsumi, Matsumoto, Nagisa, Ogawa, Shoujiro, Mitamura, Kuniko, Ikegawa, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - chemistry Boronic Acids - chemistry Chromatography, Liquid - methods derivatization detectability electrospray ionization-MS/MS Humans Hydroxycholesterols - blood Hydroxycholesterols - chemistry Hydroxycholesterols - urine Pregnanetriol - chemistry Pyridines - chemistry Spectrometry, Mass, Electrospray Ionization - methods steroid Steroids - chemistry Tandem Mass Spectrometry - methods vicinal diol
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