In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to 382±23.9nm), uniform size distribution and positive zeta potentia...

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Veröffentlicht in:	International journal of pharmaceutics 2013-02, Vol.444 (1-2), p.10-17
Hauptverfasser:	Booysen, L.L.I.J., Kalombo, L., Brooks, E., Hansen, R., Gilliland, J., Gruppo, V., Lungenhofer, P., Semete-Makokotlela, B., Swai, H.S., Kotze, A.F., Lenaerts, A., du Plessis, L.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antitubercular - administration & dosage Antibiotics, Antitubercular - chemistry Antibiotics, Antitubercular - pharmacokinetics chemotherapy Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Compounding drugs emulsions encapsulation evaporation Female In vitro In vivo Isoniazid Isoniazid - administration & dosage Isoniazid - chemistry Isoniazid - pharmacokinetics Lactic Acid - chemistry liver lungs Mice Mice, Inbred BALB C Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects nanocapsules nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry oral administration Particle Size PEG coated Pharmacodynamic Pharmacokinetic pharmacokinetics PLGA nanoparticles polyethylene glycol Polyglycolic Acid - chemistry protein binding Rifampicin Rifampin - administration & dosage Rifampin - chemistry Rifampin - pharmacokinetics solvents spray drying tuberculosis zeta potential
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