Suppressive Effects of SuHeXiang Wan on Amyloid-β42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic Drosophila Model of Alzheimer's Disease

SuHeXiang Wan (SHXW), a Chinese traditional medicine, has been used to treat infantile convulsions, seizures and strokes. Previously, we reported that modified SHXW, called KSOP1009, suppressed the hyper-activation of c-Jun N-terminal kinase (JNK) and Alzheimer's disease (AD)-like phenotypes in...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2013/03/01, Vol.36(3), pp.390-398
Hauptverfasser:	Park, Seung Hwan, Lee, Soojin, Hong, Yoon Ki, Hwang, Soojin, Lee, Jang Ho, Bang, Se Min, Kim, Young-Kyoon, Koo, Byung-Soo, Lee, Im-Soon, Cho, Kyoung Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - toxicity amyloid-β42 Animals Animals, Genetically Modified Cell Proliferation - drug effects Disease Models, Animal Drosophila Drugs, Chinese Herbal - pharmacology ErbB Receptors - physiology extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism glial cell Humans Neuroglia - drug effects Neuroprotective Agents - pharmacology Phosphorylation SuHeXiang Wan
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