Clinical significance following breast conservation therapy with or without irradiation in breast cancer patients
We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy. We retrospectively evaluated a total of 1197 Japanese female breast ca...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2013-03, Vol.43 (3), p.251-257 |
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| container_title | Japanese journal of clinical oncology |
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| creator | Tamaki, Kentaro Tamaki, Nobumitsu Kamada, Yoshihiko Uehara, Kanou Ohuchi, Noriaki Miyashita, Minoru Ishida, Takanori Sasano, Hironobu |
| description | We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy.
We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The median age of the patients was 54 years (range: 24-99 years). We retrospectively examined the local recurrence-free survival rates in those with or without post-operative irradiation according to age, surgical margin status and histopathological characteristics including histological grade, estrogen receptor expression and HER2 status.
Local recurrence-free survival rates in the irradiated group were significantly higher than those in the non-irradiated group, especially in surgical margin-positive [hazard ratio (HR): 0.334, 95% confidence interval: 0.14-0.79, P = 0.001], estrogen receptor-positive (HR: 0.249, 95% confidence interval: 0.11-0.54, P < 0.001), HER2-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) and non-triple-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) breast cancer patients.
The results indicated that irradiation after breast-conserving therapy is strongly recommended in Japanese breast cancer patients, especially those with surgically positive margins, estrogen receptor-positive tumors and HER2-negative invasive breast cancers. |
| doi_str_mv | 10.1093/jjco/hys214 |
| format | Article |
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We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The median age of the patients was 54 years (range: 24-99 years). We retrospectively examined the local recurrence-free survival rates in those with or without post-operative irradiation according to age, surgical margin status and histopathological characteristics including histological grade, estrogen receptor expression and HER2 status.
Local recurrence-free survival rates in the irradiated group were significantly higher than those in the non-irradiated group, especially in surgical margin-positive [hazard ratio (HR): 0.334, 95% confidence interval: 0.14-0.79, P = 0.001], estrogen receptor-positive (HR: 0.249, 95% confidence interval: 0.11-0.54, P < 0.001), HER2-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) and non-triple-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) breast cancer patients.
The results indicated that irradiation after breast-conserving therapy is strongly recommended in Japanese breast cancer patients, especially those with surgically positive margins, estrogen receptor-positive tumors and HER2-negative invasive breast cancers.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hys214</identifier><identifier>PMID: 23277499</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Recurrence, Local ; Radiotherapy, Adjuvant ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Retrospective Studies ; Survival Rate ; Young Adult</subject><ispartof>Japanese journal of clinical oncology, 2013-03, Vol.43 (3), p.251-257</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-e87722cddbd85e17a796b4ff3e9c1a42bad5cc0cd070caa4caa125a0f403406b3</citedby><cites>FETCH-LOGICAL-c313t-e87722cddbd85e17a796b4ff3e9c1a42bad5cc0cd070caa4caa125a0f403406b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23277499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamaki, Kentaro</creatorcontrib><creatorcontrib>Tamaki, Nobumitsu</creatorcontrib><creatorcontrib>Kamada, Yoshihiko</creatorcontrib><creatorcontrib>Uehara, Kanou</creatorcontrib><creatorcontrib>Ohuchi, Noriaki</creatorcontrib><creatorcontrib>Miyashita, Minoru</creatorcontrib><creatorcontrib>Ishida, Takanori</creatorcontrib><creatorcontrib>Sasano, Hironobu</creatorcontrib><title>Clinical significance following breast conservation therapy with or without irradiation in breast cancer patients</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy.
We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The median age of the patients was 54 years (range: 24-99 years). We retrospectively examined the local recurrence-free survival rates in those with or without post-operative irradiation according to age, surgical margin status and histopathological characteristics including histological grade, estrogen receptor expression and HER2 status.
Local recurrence-free survival rates in the irradiated group were significantly higher than those in the non-irradiated group, especially in surgical margin-positive [hazard ratio (HR): 0.334, 95% confidence interval: 0.14-0.79, P = 0.001], estrogen receptor-positive (HR: 0.249, 95% confidence interval: 0.11-0.54, P < 0.001), HER2-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) and non-triple-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) breast cancer patients.
The results indicated that irradiation after breast-conserving therapy is strongly recommended in Japanese breast cancer patients, especially those with surgically positive margins, estrogen receptor-positive tumors and HER2-negative invasive breast cancers.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Breast Neoplasms - surgery</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Mastectomy, Segmental</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Radiotherapy, Adjuvant</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAQhi0EoqUwsSOPSCjUZztxMqKKL6kSC8yR4zitq9RObYeq_56UQIfTezo99w4PQrdAHoEUbL7ZKDdfHwIFfoamwLM0YRmFczQlLMsTmgNM0FUIG0JImnNxiSaUUSF4UUzRbtEaa5RscTAra5phtUrjxrWt2xu7wpXXMkSsnA3af8tonMVxrb3sDnhv4ho7_5uuj9h4L2szMsaeXo-NHnfDXdsYrtFFI9ugb_5yhr5enj8Xb8ny4_V98bRMFAMWE50LQamq66rOUw1CiiKreNMwXSiQnFayTpUiqiaCKCn5MEBTSRpOGCdZxWbofuztvNv1OsRya4LSbSutdn0ogQFnFNIsHdCHEVXeheB1U3bebKU_lEDKo-Py6LgcHQ_03V9xX211fWL_pbIfgId8vw</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Tamaki, Kentaro</creator><creator>Tamaki, Nobumitsu</creator><creator>Kamada, Yoshihiko</creator><creator>Uehara, Kanou</creator><creator>Ohuchi, Noriaki</creator><creator>Miyashita, Minoru</creator><creator>Ishida, Takanori</creator><creator>Sasano, Hironobu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Clinical significance following breast conservation therapy with or without irradiation in breast cancer patients</title><author>Tamaki, Kentaro ; Tamaki, Nobumitsu ; Kamada, Yoshihiko ; Uehara, Kanou ; Ohuchi, Noriaki ; Miyashita, Minoru ; Ishida, Takanori ; Sasano, Hironobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-e87722cddbd85e17a796b4ff3e9c1a42bad5cc0cd070caa4caa125a0f403406b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Breast Neoplasms - surgery</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Mastectomy, Segmental</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Radiotherapy, Adjuvant</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamaki, Kentaro</creatorcontrib><creatorcontrib>Tamaki, Nobumitsu</creatorcontrib><creatorcontrib>Kamada, Yoshihiko</creatorcontrib><creatorcontrib>Uehara, Kanou</creatorcontrib><creatorcontrib>Ohuchi, Noriaki</creatorcontrib><creatorcontrib>Miyashita, Minoru</creatorcontrib><creatorcontrib>Ishida, Takanori</creatorcontrib><creatorcontrib>Sasano, Hironobu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamaki, Kentaro</au><au>Tamaki, Nobumitsu</au><au>Kamada, Yoshihiko</au><au>Uehara, Kanou</au><au>Ohuchi, Noriaki</au><au>Miyashita, Minoru</au><au>Ishida, Takanori</au><au>Sasano, Hironobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance following breast conservation therapy with or without irradiation in breast cancer patients</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>43</volume><issue>3</issue><spage>251</spage><epage>257</epage><pages>251-257</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy.
We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The median age of the patients was 54 years (range: 24-99 years). We retrospectively examined the local recurrence-free survival rates in those with or without post-operative irradiation according to age, surgical margin status and histopathological characteristics including histological grade, estrogen receptor expression and HER2 status.
Local recurrence-free survival rates in the irradiated group were significantly higher than those in the non-irradiated group, especially in surgical margin-positive [hazard ratio (HR): 0.334, 95% confidence interval: 0.14-0.79, P = 0.001], estrogen receptor-positive (HR: 0.249, 95% confidence interval: 0.11-0.54, P < 0.001), HER2-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) and non-triple-negative (HR: 0.382, 95% confidence interval: 0.21-0.69, P = 0.001) breast cancer patients.
The results indicated that irradiation after breast-conserving therapy is strongly recommended in Japanese breast cancer patients, especially those with surgically positive margins, estrogen receptor-positive tumors and HER2-negative invasive breast cancers.</abstract><cop>England</cop><pmid>23277499</pmid><doi>10.1093/jjco/hys214</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Oxford Journals |
| subjects | Adult Aged Aged, 80 and over Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Combined Modality Therapy Disease-Free Survival Female Humans Mastectomy, Segmental Middle Aged Neoplasm Recurrence, Local Radiotherapy, Adjuvant Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Survival Rate Young Adult |
| title | Clinical significance following breast conservation therapy with or without irradiation in breast cancer patients |
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