Overexpression of GPC3 inhibits hepatocellular carcinoma cell proliferation and invasion through induction of apoptosis

Glypican-3 (GPC3) is a membrane heparan sulfate proteoglycan involved in cell proliferation, differentiation, adhesion, migration and the development of the majority of mesodermal tissues and organs. GPC3 has been found to be important for the occurrence and development of hepatocellular carcinoma (...

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Veröffentlicht in:	Molecular medicine reports 2013-03, Vol.7 (3), p.969-974
Hauptverfasser:	PAN, ZHIJIAN, CHEN, CHUNZHOU, LONG, HAOCHENG, LEI, CHANGJIANG, TANG, GANG, LI, LEI, FENG, JIARUI, CHEN, FEIXIANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Apoptosis Apoptosis - drug effects Breast cancer Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell culture Cell death Cell growth Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacology Flow cytometry Genetic Vectors - metabolism glypican-3 Glypicans - genetics Glypicans - metabolism Heparan sulfate proteoglycans Hepatocellular carcinoma hepatocellular carcinoma cells Humans Insulin Insulin-like growth factor II Insulin-Like Growth Factor II - pharmacology Insulin-like growth factors Ligands Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Metastasis Mortality Proteins RNA, Messenger - metabolism Stem cells Studies Sulfates Transfection Tumors
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