Sleep Disturbances in Alzheimer’s Disease Are Associated With Neuropsychiatric Symptoms and Antidementia Treatment
ABSTRACTSleep disturbances (SDs) in Alzheimer’s disease (AD) may significantly affect the behavioral, functional, and cognitive capacities of patients to the point of becoming a major determinant of caregiver burden. We conducted a cross-sectional study in 125 patients with probable AD to assess the...
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| Veröffentlicht in: | The journal of nervous and mental disease 2013-03, Vol.201 (3), p.251-257 |
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| container_title | The journal of nervous and mental disease |
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| creator | García-Alberca, José María Lara, José Pablo Cruz, Belén Garrido, Victoria Gris, Esther Barbancho, Miguel Ángel |
| description | ABSTRACTSleep disturbances (SDs) in Alzheimer’s disease (AD) may significantly affect the behavioral, functional, and cognitive capacities of patients to the point of becoming a major determinant of caregiver burden. We conducted a cross-sectional study in 125 patients with probable AD to assess the association of SDs with neuropsychiatric symptoms, cognitive and functional status of patients, and severity and duration of dementia and to ascertain the role of antidementia drugs in the treatment of SD. SDs were assessed using the questionnaire on sleep disorders in the Neuropsychiatric Inventory. The prevalence of SDs in this sample was 36%. SDs in patients with AD are significantly associated with depression (Wald’s test, 3.983; p < 0.05), disinhibition (Wald’s test, 5.522; p < 0.05), and aberrant motor behavior (Wald’s test, 7.430; p < 0.01). The patients treated with memantine presented lower mean SDs scores (t = 2.76; p < 0.001). These results highlight the need for a standardized and validated approach to the assessment of SDs in AD. |
| doi_str_mv | 10.1097/NMD.0b013e3182848d04 |
| format | Article |
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We conducted a cross-sectional study in 125 patients with probable AD to assess the association of SDs with neuropsychiatric symptoms, cognitive and functional status of patients, and severity and duration of dementia and to ascertain the role of antidementia drugs in the treatment of SD. SDs were assessed using the questionnaire on sleep disorders in the Neuropsychiatric Inventory. The prevalence of SDs in this sample was 36%. SDs in patients with AD are significantly associated with depression (Wald’s test, 3.983; p < 0.05), disinhibition (Wald’s test, 5.522; p < 0.05), and aberrant motor behavior (Wald’s test, 7.430; p < 0.01). The patients treated with memantine presented lower mean SDs scores (t = 2.76; p < 0.001). These results highlight the need for a standardized and validated approach to the assessment of SDs in AD.</description><identifier>ISSN: 0022-3018</identifier><identifier>EISSN: 1539-736X</identifier><identifier>DOI: 10.1097/NMD.0b013e3182848d04</identifier><identifier>PMID: 23407210</identifier><identifier>CODEN: JNMDAN</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - drug therapy ; Alzheimer Disease - epidemiology ; Alzheimer's disease ; Biological and medical sciences ; Cognition & reasoning ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Comorbidity ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Dopamine Agents - adverse effects ; Dopamine Agents - therapeutic use ; Drug therapy ; Female ; Humans ; Male ; Medical sciences ; Mental depression ; Mental health care ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Sleep disorders ; Sleep Wake Disorders - chemically induced ; Sleep Wake Disorders - diagnosis ; Sleep Wake Disorders - epidemiology</subject><ispartof>The journal of nervous and mental disease, 2013-03, Vol.201 (3), p.251-257</ispartof><rights>2013 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Mar 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4144-15b02a0238a5ded1e3f3a03fc8045dc83ffddcbf4250c91341634b8d11e0f9da3</citedby><cites>FETCH-LOGICAL-c4144-15b02a0238a5ded1e3f3a03fc8045dc83ffddcbf4250c91341634b8d11e0f9da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27170798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23407210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Alberca, José María</creatorcontrib><creatorcontrib>Lara, José Pablo</creatorcontrib><creatorcontrib>Cruz, Belén</creatorcontrib><creatorcontrib>Garrido, Victoria</creatorcontrib><creatorcontrib>Gris, Esther</creatorcontrib><creatorcontrib>Barbancho, Miguel Ángel</creatorcontrib><title>Sleep Disturbances in Alzheimer’s Disease Are Associated With Neuropsychiatric Symptoms and Antidementia Treatment</title><title>The journal of nervous and mental disease</title><addtitle>J Nerv Ment Dis</addtitle><description>ABSTRACTSleep disturbances (SDs) in Alzheimer’s disease (AD) may significantly affect the behavioral, functional, and cognitive capacities of patients to the point of becoming a major determinant of caregiver burden. We conducted a cross-sectional study in 125 patients with probable AD to assess the association of SDs with neuropsychiatric symptoms, cognitive and functional status of patients, and severity and duration of dementia and to ascertain the role of antidementia drugs in the treatment of SD. SDs were assessed using the questionnaire on sleep disorders in the Neuropsychiatric Inventory. The prevalence of SDs in this sample was 36%. SDs in patients with AD are significantly associated with depression (Wald’s test, 3.983; p < 0.05), disinhibition (Wald’s test, 5.522; p < 0.05), and aberrant motor behavior (Wald’s test, 7.430; p < 0.01). The patients treated with memantine presented lower mean SDs scores (t = 2.76; p < 0.001). These results highlight the need for a standardized and validated approach to the assessment of SDs in AD.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Dopamine Agents - adverse effects</subject><subject>Dopamine Agents - therapeutic use</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mental health care</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Sleep disorders</subject><subject>Sleep Wake Disorders - chemically induced</subject><subject>Sleep Wake Disorders - diagnosis</subject><subject>Sleep Wake Disorders - epidemiology</subject><issn>0022-3018</issn><issn>1539-736X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdtqFTEUhoModlt9A5GACN5MXTlMJ3O5aT1BrRet6N2QSVaY1DmZZCjbK1_D1_NJzLC3Cr3wIvwh-f7Fgo-QpwxOGNTVq8sP5yfQAhMomOJKKgvyHtmwUtRFJU6_3CcbAM4LAUwdkUcx3gCwSkh4SI54jooz2JB01SPO9NzHtIRWjwYj9SPd9t879AOGXz9-xvUXdUS6DfnEOBmvE1r62aeOXuISpjnuTJcfgzf0ajfMaRoi1aOl2zF5iwPm0PQ6oE7r_TF54HQf8ckhj8mnN6-vz94VFx_fvj_bXhRGMikLVrbANXChdGnRMhROaBDOKJClNUo4Z61pneQlmJoJyU6FbJVlDMHVVotj8nI_dw7TtwVjagYfDfa9HnFaYsPEWqo5iIw-v4PeTEsY83YrJctacsUzJfeUCVOMAV0zBz_osGsYNKuVJltp7lrJtWeH4Us7oP1b-qMhAy8OgI5G9y5kET7-4ypWQVWrzKk9dzv1CUP82i-3GJoOdZ-6_-_wG21EqXA</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>García-Alberca, José María</creator><creator>Lara, José Pablo</creator><creator>Cruz, Belén</creator><creator>Garrido, Victoria</creator><creator>Gris, Esther</creator><creator>Barbancho, Miguel Ángel</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Sleep Disturbances in Alzheimer’s Disease Are Associated With Neuropsychiatric Symptoms and Antidementia Treatment</title><author>García-Alberca, José María ; Lara, José Pablo ; Cruz, Belén ; Garrido, Victoria ; Gris, Esther ; Barbancho, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4144-15b02a0238a5ded1e3f3a03fc8045dc83ffddcbf4250c91341634b8d11e0f9da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Dopamine Agents - adverse effects</topic><topic>Dopamine Agents - therapeutic use</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Mental health care</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Sleep disorders</topic><topic>Sleep Wake Disorders - chemically induced</topic><topic>Sleep Wake Disorders - diagnosis</topic><topic>Sleep Wake Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Alberca, José María</creatorcontrib><creatorcontrib>Lara, José Pablo</creatorcontrib><creatorcontrib>Cruz, Belén</creatorcontrib><creatorcontrib>Garrido, Victoria</creatorcontrib><creatorcontrib>Gris, Esther</creatorcontrib><creatorcontrib>Barbancho, Miguel Ángel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of nervous and mental disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Alberca, José María</au><au>Lara, José Pablo</au><au>Cruz, Belén</au><au>Garrido, Victoria</au><au>Gris, Esther</au><au>Barbancho, Miguel Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep Disturbances in Alzheimer’s Disease Are Associated With Neuropsychiatric Symptoms and Antidementia Treatment</atitle><jtitle>The journal of nervous and mental disease</jtitle><addtitle>J Nerv Ment Dis</addtitle><date>2013-03</date><risdate>2013</risdate><volume>201</volume><issue>3</issue><spage>251</spage><epage>257</epage><pages>251-257</pages><issn>0022-3018</issn><eissn>1539-736X</eissn><coden>JNMDAN</coden><abstract>ABSTRACTSleep disturbances (SDs) in Alzheimer’s disease (AD) may significantly affect the behavioral, functional, and cognitive capacities of patients to the point of becoming a major determinant of caregiver burden. We conducted a cross-sectional study in 125 patients with probable AD to assess the association of SDs with neuropsychiatric symptoms, cognitive and functional status of patients, and severity and duration of dementia and to ascertain the role of antidementia drugs in the treatment of SD. SDs were assessed using the questionnaire on sleep disorders in the Neuropsychiatric Inventory. The prevalence of SDs in this sample was 36%. SDs in patients with AD are significantly associated with depression (Wald’s test, 3.983; p < 0.05), disinhibition (Wald’s test, 5.522; p < 0.05), and aberrant motor behavior (Wald’s test, 7.430; p < 0.01). The patients treated with memantine presented lower mean SDs scores (t = 2.76; p < 0.001). These results highlight the need for a standardized and validated approach to the assessment of SDs in AD.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>23407210</pmid><doi>10.1097/NMD.0b013e3182848d04</doi><tpages>7</tpages></addata></record> |
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| ispartof | The journal of nervous and mental disease, 2013-03, Vol.201 (3), p.251-257 |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - drug therapy Alzheimer Disease - epidemiology Alzheimer's disease Biological and medical sciences Cognition & reasoning Cognition Disorders - diagnosis Cognition Disorders - epidemiology Comorbidity Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Dopamine Agents - adverse effects Dopamine Agents - therapeutic use Drug therapy Female Humans Male Medical sciences Mental depression Mental health care Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Sleep disorders Sleep Wake Disorders - chemically induced Sleep Wake Disorders - diagnosis Sleep Wake Disorders - epidemiology |
| title | Sleep Disturbances in Alzheimer’s Disease Are Associated With Neuropsychiatric Symptoms and Antidementia Treatment |
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